miR‐338‐3p suppresses neuroblastoma proliferation, invasion and migration through targeting PREX2a
Abstract
MicroRNAs (miRNA) can regulate cancer cell proliferation and metastasis. Here, we show that miR‐338‐3p is down‐regulated in metastatic tumor tissues compared to primary tumors, and that that miR‐338‐3p can inhibit cell proliferation by inducing cell cycle arrest, as well as restrain cell migration and invasion. PREX2a is confirmed as a direct target of miR‐338‐3p. Knockdown of PREX2a inhibits cell proliferation, migration and invasion through the PTEN/Akt pathway. miR‐338‐3p‐dependent inhibition of proliferation and invasion can be rescued by PREXa. Overall, this study demonstrates that miR‐338‐3p affects the PTEN/Akt pathway by down‐regulating PREX2a. This newly identified function of miR‐338‐3p provides novel insights into neuroblastoma and may foster therapeutic applications.
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MiR-338-3p has previously been implicated in tumor suppression in hepatocarcinoma, gastric cancer, and brain cancer.
“MiR-338-3p has previously been implicated in tumor suppression in hepatocarcinoma, gastric cancer, and brain cancer [40–44].”
From MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation. (2017) · cites this paper as [43]
miR-338-3p's inhibition of PREX2a is crucial in suppression of neuroblastoma proliferation.
“Prior studies have already shown miR-338-3p’s inhibition of PREX2a is crucial in suppression of neuroblastoma proliferation [43].”
From MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation. (2017) · cites this paper as [43]
PREX2a inhibits Pten activity.
“PREX2a inhibits Pten activity itself”
From MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation. (2017) · cites this paper as [43]
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Research works printed but not linked: 1
- Huang, T.C., Chang, H.Y., Chen, C.Y., et al. (2011) Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR. FEBS Lett. 585 (22), 3582-3586.
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MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation.
Howe, J. R., Li, E. S., Streeter, S. E., Rahme, G. J., Chipumuro, E., Russo, G. B., Litzky, J. F., Hills, L. B., Rodgers, K. R., Skelton, P. D., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177661 · Cited by 41 · see citing works
MiR-338-3p inhibits TNF-α-induced lipogenesis in human sebocytes.
Liu, J., Cao, L., Feng, Y., Li, Y., & Li, T. (2017) · Biotechnology Letters · doi:10.1007/s10529-017-2369-3 · Cited by 20 · see citing works
- Authors
- Chen, X., Pan, M., Han, L., Lu, H., Hao, X., & Dong, Q.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2013-10-15
- Volume
- 587
- Issue
- 22
- Pages
- 3729-3737
- ISSN
- 0014-5793
- 1873-3468
- Cited by
- 88
- References
- 0
- Language
- en
- Funders
- National Natural Science Foundation of China (81272986)
- Natural Science Foundation of Shangdong Province of China (ZR2011HZ002)
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