Cited by 118Ion Transport and Channel RegulationDrug Transport and Resistance MechanismsAmino Acid Enzymes and Metabolism

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Inositol transport proteins

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Schneider, Sabine·2015·FEBS Letters

DOI 10.1016/j.febslet.2015.03.012

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Abstract

The cyclic polyol myo ‐inositol is a key molecule in many different metabolic pathways among all organisms; in addition, it is fundamental for osmotic balance in the mammalian brain. This review sums up inositol transporters from eukaryotic organisms, elucidating their vital role in regulating the intracellular distribution and uptake of inositol. They can be divided into two groups according to their transport mechanisms: (1) sodium ion coupled inositol transporters that belong to the Solute Carrier Families 5 and 6‐like Superfamily and, (2) proton coupled inositol symporters that are members of the Major Facilitator Superfamily. Intriguingly members of both families offer promising targets for medical treatment of a variety of diseases.

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“On the other hand, it can be found in the cell membranes as phosphatidyl-myoinositol as the precursor of inositol triphosphate (PIP2), which plays a crucial role [52] in the signal transduction of various receptors, including FSH, promoting granulosa cell differentiation and follicle maturation [47].”
Background
Nutritional and Acquired Deficiencies in Inositol Bioavailability. Correlations with Metabolic Disorders
Dinicola, S., Minini, M., Unfer, V., Verna, R., Cucina, A., & Bizzarri, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102187 · Cited by 114

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Authors: Schneider, S.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author: Schneider, Sabine
ORCID: Schneider, Sabine
Venue: FEBS Letters
Publisher: Wiley
Published: 2015-03-24
Volume: 589
Issue: 10
Pages: 1049-1058
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2015.03.012
OpenAlex: W2066672442
Cited by: 118
References: 111
Citations by year: 2026: 5 · 2025: 17 · 2024: 5 · 2023: 13 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 8 · 2015: 2
FWCI: 0.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords: myo-inositol, major facilitator superfamily, osmotic balance, brain, therapeutic target
MeSH terms: Animals, Biological Transport, Active, Brain, Brain Chemistry, Carrier Proteins, Humans, Inositol, Symporters

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