The DOI matches its Crossref record; 109 of the 111 references it cites were found in a registry or an index.
Inositol transport proteins
Open accessAbstract
The cyclic polyol myo ‐inositol is a key molecule in many different metabolic pathways among all organisms; in addition, it is fundamental for osmotic balance in the mammalian brain. This review sums up inositol transporters from eukaryotic organisms, elucidating their vital role in regulating the intracellular distribution and uptake of inositol. They can be divided into two groups according to their transport mechanisms: (1) sodium ion coupled inositol transporters that belong to the Solute Carrier Families 5 and 6‐like Superfamily and, (2) proton coupled inositol symporters that are members of the Major Facilitator Superfamily. Intriguingly members of both families offer promising targets for medical treatment of a variety of diseases.
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“On the other hand, it can be found in the cell membranes as phosphatidyl-myoinositol as the precursor of inositol triphosphate (PIP2), which plays a crucial role [52] in the signal transduction of various receptors, including FSH, promoting granulosa cell differentiation and follicle maturation [47].”
From Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials (2023) · cites this paper as [52]
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Plant sugars: Homeostasis and transport under abiotic stress in plants
Saddhe, A. A., Manuka, R., & Suprasanna, P. (2020) · Physiologia Plantarum · doi:10.1111/ppl.13283 · Cited by 436
Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease
Bizzarri, M., Fuso, A., Dinicola, S., Cucina, A., & Bevilacqua, A. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2016.1206887 · Cited by 185
Inositols in Insulin Signaling and Glucose Metabolism
Bevilacqua, A., & Bizzarri, M. (2018) · International Journal of Endocrinology · doi:10.1155/2018/1968450 · Cited by 192
Greff, D., Juhász, A. E., Váncsa, S., Váradi, A., Sipos, Z., Szinte, J., Park, S., Hegyi, P., Nyirády, P., Ács, N., et al. (2023) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-023-01055-z · Cited by 143
“On the other hand, it can be found in the cell membranes as phosphatidyl-myoinositol as the precursor of inositol triphosphate (PIP2), which plays a crucial role [52] in the signal transduction of various receptors, including FSH, promoting granulosa cell differentiation and follicle maturation [47].”
BackgroundDinicola, S., Minini, M., Unfer, V., Verna, R., Cucina, A., & Bizzarri, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102187 · Cited by 114
Metadata
- Authors
- Schneider, S.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Corresponding author
- Schneider, Sabine
- ORCID
- Schneider, Sabine
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2015-03-24
- Volume
- 589
- Issue
- 10
- Pages
- 1049-1058
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2066672442
- Cited by
- 118
- References
- 111
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 5 · 2023: 13 · 2022: 13 · 2021: 10 · 2020: 17 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 8 · 2015: 2
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- myo-inositol, major facilitator superfamily, osmotic balance, brain, therapeutic target
- MeSH terms
- Animals, Biological Transport, Active, Brain, Brain Chemistry, Carrier Proteins, Humans, Inositol, Symporters
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