Performance of the postwash total motile sperm count as a predictor of pregnancy at the time of intrauterine insemination: A meta-analysis
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Objective To assess the performance and clinical value of the postwash total motile sperm count (postwash TMC) as a test to predict intrauterine insemination (IUI) outcome. Design Meta-analysis of diagnostic tests. Setting Tertiary fertility center. Patient(s) Patients undergoing IUI. Intervention(s) None. Result(s) We detected 16 studies that reported on postwash TMC at insemination and IUI outcome. Summary receiver operating characteristics (ROC) curves indicated a reasonable predictive performance toward IUI outcome, and, at cut-off levels between 0.8 to 5 million motile spermatozoa, the postwash TMC provided a substantial discriminative performance. At these cut-off levels, the specificity of the postwash TMC, defined as the ability to predict failure to become pregnant, was as high as 100%; the sensitivity of the test, defined as the ability to predict pregnancy, was limited. Conclusion(s) The postwash TMC at insemination could potentially be used in counseling patients for either IUI or IVF. However, to enable patient counseling before the start of treatment, further studies are needed to establish the accuracy of a postwash TMC during the fertility workup rather than at insemination.
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Van der Weert et al. (2004) showed in a meta-analysis of 16 studies that a postwash TMSC between 0.8 × 10 6 and 5 × 10 6 has a prognostic value in couples who underwent IUI.
“Van der Weert et al. (2004) showed in a metaanalysis of 16 studies that a postwash TMSC of between 0.8 × 10 6 and 5 × 10 6 has a prognostic value in couples who underwent IUI.”
From Total motile sperm count: a better indicator for the severity of male factor infertility than the WHO sperm classification system (2015) · cites this paper as Van der Weert et al. (2004)
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Hamilton, J. A. M., Cissen, M., Brandes, M., Smeenk, J. M. J., de Bruin, J. P., Kremer, J. A. M., Nelen, W. L. D. M., & Hamilton, C. J. C. M. (2015) · Human Reproduction · doi:10.1093/humrep/dev058 · Cited by 236 · see citing works
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- Authors
- van Weert, J.-M., Repping, S., Van Voorhis, B. J., van der Veen, F., Bossuyt, P. M. M., & Mol, B. W. J.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 82
- Issue
- 3
- Pages
- 612-620
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2128487912
- Cited by
- 138
- References
- 4
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 12 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 12 · 2015: 2 · 2014: 5 · 2013: 12 · 2012: 3
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Iowa Research Online (The University of Iowa) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
- Keywords
- intrauterine insemination, pregnancy prediction, diagnostic performance, sensitivity and specificity, patient counseling, infertility workup
- MeSH terms
- Female, Humans, Insemination, Artificial, Male, Pregnancy, Pregnancy Outcome, Sperm Motility, MEDLINE, Treatment Outcome
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