The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis
Open accessAbstract
Objective To discuss the role that reduced endometrial responsiveness to progesterone (P) might play in the pathophysiology of endometriosis. Design A review of experimental evidence regarding the failure of P to regulate the expression of matrix metalloproteinases (MMPs) in the endometrium of patients with endometriosis. Conclusion(s) Progesterone and locally produced differentiation factors act cooperatively to reduce MMP expression by maternal endometrial cells within the pro-inflammatory micro-environment of early pregnancy. Our in vitro studies with normal human endometrium demonstrate that prior P exposure not only down-regulates MMP expression, but also limits the ability of locally produced proinflammatory cytokines to stimulate expression of these enzymes. In contrast, endometrial tissues from women with endometriosis demonstrate an altered response to P, allowing a continuous expression of MMPs throughout the secretory phase. Although the factors that influence the loss of P sensitivity in the endometrium of patients with endometriosis have not yet been defined, alterations in cell-cell communication seem to contribute to dysregulated MMP expression. Specifically, proinflammatory cytokines produced by epithelial cells oppose stromal cell responses to P, inhibiting production of key differentiation factors necessary for cell-specific MMP regulation. The resulting loss in normal MMP regulation enhances the invasive capacity of endometrial tissue, promoting ectopic establishment in an experimental model.
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“A reduction in progesterone action in endometrium, 'progesterone resistance', of women with endometriosis (Osteen et al., 2005; Table V) may play a key role in development of endometriosis and possibly with associated pain; use of progestagens may reverse these effects.”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Osteen et al., 2005
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“Osteen et al. (2005) demonstrated that eutopic endometrium of women with endometriosis has reduced progesterone action during maturation or 'progesterone resistance', that, in turn, may enhance development of endometriosis.”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Osteen et al., 2005
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Cites
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334
TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN
Wolbach, S., & Howe, P. R. (1925) · Journal of Experimental Medicine · doi:10.1084/jem.42.6.753 · Cited by 1,674
Global gene profiling in human endometrium during the window of implantation
Kao, L. C., Tulac, S., Lobo, S., Imani, B., Yang, J. P., Germeyer, A., Osteen, K., Taylor, R. N., Lessey, B. A., & Giudice, L. C. (2002) · Endocrinology · doi:10.1210/endo.143.6.8885 · Cited by 727
Self-citationKao, L. C., Germeyer, A., Tulac, S., Lobo, S., Yang, J. P., Taylor, R. N., Osteen, K., Lessey, B. A., & Giudice, L. C. (2003) · Endocrinology · doi:10.1210/en.2003-0043 · Cited by 696
Self-citationCurry, T. E., & Osteen, K. G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0005 · Cited by 606
Self-citationGiguère, V. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-1-61 · Cited by 522
Vitamin A and reproduction in rats
Thompson, J. N., Howell, J., & Pitt, G. A. (1964) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1964.0017 · Cited by 381
Rodgers, W. H., Matrisian, L. M., Giudice, L. C., Dsupin, B. A., Cannon, P., Svitek, C., Gorstein, F., & Osteen, K. G. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117461 · Cited by 377
Self-citationThe Relation of Endometriosis to Menstrual Characteristics, Smoking, and Exercise
Cramer, D. W. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03370140102032 · Cited by 367
Bruner‐Tran, K. L., Matrisian, L. M., Rodgers, W. H., Gorstein, F., & Osteen, K. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119478 · Cited by 283
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1 of the 63 references couldn’t be matched to a known paper.
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- Attia, 2000, Progesterone receptor isoform A but not B is expressed in endometriosis, J Clin Endocrinol Metab, 85, 2897
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Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772
Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844
Burney, R. O., Talbi, S., Hamilton, A. E., Vo, K. C., Nyegaard, M., Nezhat, C. R., Lessey, B. A., & Giudice, L. C. (2007) · Endocrinology · doi:10.1210/en.2006-1692 · Cited by 735
Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
Kim, J. J., Kurita, T., & Bulun, S. E. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1043 · Cited by 520
The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights
Laganà, A. S., Garzon, S., Götte, M., Viganò, P., Franchi, M. P., Ghezzi, F., & Martin, D. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225615 · Cited by 503
Metadata
- Authors
- Osteen, K. G., Bruner-Tran, K. L., & Eisenberg, E.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Osteen, Kevin G.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 83
- Issue
- 3
- Pages
- 529-537
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1966049599
- Cited by
- 122
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 7 · 2021: 8 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 11
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (R21ES12298-01, R21ES012298)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (5K12HD43483, U54HD037321, U54 HD37321, K12HD043483)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, progesterone, endometrial maturation, matrix metalloproteinases, endometrial receptivity, inflammatory cytokines, endometrial invasion, luteal phase, intercellular communication, ectopic endometrium
- MeSH terms
- Endometriosis, Endometrium, Female, Humans, Pregnancy, Progesterone, Risk Factors
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