Effects of testosterone and estrogen treatment on lipolysis signaling pathways in subcutaneous adipose tissue of postmenopausal women
Open accessAbstract
Objective The aim of this study was to investigate the treatment effects of testosterone and estrogen on the expression of proteins and genes involved in adipocyte signal transduction to lipolysis in abdominal subcutaneous adipose tissue of postmenopausal women.Design An open, randomized clinical study with parallel group comparison.Setting Women's health clinical research unit and a research laboratory at a university hospital.Patient(s) Thirty-six healthy naturally postmenopausal women.Intervention(s) The participants were randomly given testosterone undecanoate (40 mg every second day) or estradiol valerate (2 mg daily) for 3 months.Main outcome measure(s) Expression of proteins and genes involved in adipocyte signal transduction to lipolysis in abdominal subcutaneous adipose tissue, determined by quantitative real-time polymerase chain reaction and Western blot, respectively, and related to plasma glycerol before or during a euglycemic hyperinsulinemic clamp.Result(s) Testosterone treatment decreased the expression of hormone-sensitive lipase and increased the expression of phosphodiesterase-3B, whereas no effect of estrogen was observed. Testosterone-induced changes in hormone-sensitive lipase expression correlated positively with corresponding changes in basal or clamp-induced plasma glycerol concentrations.Conclusion(s) Treatment with testosterone in postmenopausal women down-regulates hormone-sensitive lipase and up-regulates phosphodiesterase-3B expressions in abdominal subcutaneous adipose tissue in relation to changes in vivo of lipolytic activity, which may promote the accumulation of fat.
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Effects of estrogens differ by route of administration, and the lipolytic influence of estrogens on fat accumulation affects specific body regions.
“However, it is important to highlight that the effects of estrogens differs on the route of administration and the lipolytic influence of estrogens on fat accumulation affects specific regions of the body [71–73].”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [71]
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- Authors
- Zang, H., Rydén, M., Wåhlen, K., Dahlman-Wright, K., Arner, P., & Hirschberg, A. L.
- Affiliations
- Karolinska Institutet (SE)
- Karolinska University Hospital (SE)
- Corresponding author
- Zang, Hong
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 88
- Issue
- 1
- Pages
- 100-106
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2172210608
- Cited by
- 47
- References
- 27
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Novo Nordisk Fonden
- Hjärt-Lungfonden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- testosterone, estradiol valerate, testosterone undecanoate, postmenopausal women, lipolysis, subcutaneous adipose tissue, hormone-sensitive lipase, PDE3B, plasma glycerol, hyperinsulinemic-euglycemic clamp, fat deposition
- MeSH terms
- Estrogens, Female, Humans, Lipolysis, Middle Aged, Testosterone, Signal Transduction, Postmenopause, Subcutaneous Fat
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