The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.
Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis
Open accessAbstract
Objective To investigate types of nerve fibers in endometrium and myometrium in women with endometriosis. Design Laboratory study using human tissue. Setting University-based laboratory. Patient(s) Women with and without endometriosis undergoing hysterectomy. Intervention(s) Histologic sections of contiguous endometrial and myometrial tissues were prepared from hysterectomies performed on women with and without endometriosis. Main outcome measure(s) Types and density of nerve fibers in endometrium and myometrium in women with and without endometriosis were determined using a series of specific markers for neuronal structure and function: PGP9.5, NF, SP, CGRP, TH, VAChT, VIP, and NPY. Result(s) Nerve fibers stained with PGP9.5 and NF in endometrium and myometrium were significantly increased in women with endometriosis compared with women without endometriosis. Nerve fibers in the functional layer of endometrium in women with endometriosis were likely to be sensory C, a mixture of sensory A delta, sensory C, and adrenergic fibers in the basal layer of the endometrium, a mixture of sensory A delta, sensory C, adrenergic and cholinergic fibers in the myometrium. Conclusion(s) Increased nerve fiber density in endometrium and myometrium, and sensory C fibers and adrenergic nerve fibers in the endometrium in women with endometriosis may play an important role in the mechanisms of pain generation in this condition.
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“Peripheral factors associated with painful endometriosis are found in women without endometriosis, such as increased eutopic uterine innervation”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Tokushige et al., 2007
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Cites
Revised American Society for Reproductive Medicine classification of endometriosis: 1996
American Society for Reproductive Medicine (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81391-x · Cited by 3,018
BCL-2 GENE FAMILY IN THE NERVOUS SYSTEM
Merry, D. E., & Korsmeyer, S. J. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.245 · Cited by 583
Singer, C. A., Figueroa, X. A., Batchelor, R. H., & Dorsa, D. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02455.1999 · Cited by 578
Sohrabji, F., Miranda, R. C., & Toran‐Allerand, C. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11110 · Cited by 560
Mechanisms of Pain in Arthritis
Schaible, H., Ebersberger, A., & von Banchet, G. S. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04234.x · Cited by 515
Singh, M., Meyer, E. M., & Simpkins, J. W. (1995) · Endocrinology · doi:10.1210/endo.136.5.7720680 · Cited by 425
Nervous control of the urogenital system
Maggi, C. A. (1993) · Harwood Academic Publishers eBooks · Cited by 368
Nilsen, J., & Brinton, R. D. (2002) · Endocrinology · doi:10.1210/endo.143.1.8582 · Cited by 331
Calcitonin gene-related peptide is a potent inhibitor of substance P degradation
Grevès, P. L., Nyberg, F., Terenius, L. Y., & Hökfelt, T. G. M. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90706-x · Cited by 323
Weihe, E., Tao-Cheng, J.-H., Schäfer, M., Erickson, J. D., & Eiden, L. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3547 · Cited by 301
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Items 101–151 of 151
Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways
Olteanu, I.-L., Pușcașu, C., Andrei, C., & Zanfirescu, A. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48050528 · Cited by 2
Canis, M. J., Matsuzaki, S., Rivoire, C., Jardon, K., Tamburro, S., Rabischong, B., & Mage, G. (2007) · Douleur et Analgésie · doi:10.1007/s11724-007-0049-0 · Cited by 2
Mecanismos fisiopatológicos da dor pélvica na endometriose profunda
Bier, D., Podgaec, S., & Abrão, M. S. (2011) · Cited by 2
Detection of myocardial infarction by CT angiography
Heston, T. F. (2009) · Heart · doi:10.1136/hrt.2009.169508 · Cited by 2
Fattori, V., Zaninelli, T. H., Rasquel-Oliveira, F. S., Heintz, O. K., Jain, A. K., Sun, L., Seshan, M. L., Peterse, D., Lindholm, A. E., Anchan, R. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.28.555101 · Cited by 2
Hernández-Hernández, O. T., Velázquez-Hernández, D. M., & Camacho‐Arroyo, I. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48070649 · Cited by 1
Scoring of Endometriosis: Relation to Nerve Fiber Density in Endometrial Biopsy
Hemeda, H., El‐Shourbagy, M., Nasr-addin, M. A., El-Refaee, T. A., Ahmed, A. A., & Awad, N. M. (2015) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000217 · Cited by 1
Preparing the Endometrium to Maximize Success: The Dynamics of Artificial Cycles
de Ziegler, D., Streuli, I., Marszałek, A., Gayet, V., & Chapron, C. (2013) · Springer eBooks · doi:10.1007/978-1-4471-2392-7_9
REVIEW ARTICLE: ENDOMETRIAL NERVE FIBRES IN ENDOMETRIOSIS
Tokushige, N., Jefout, M. A., Salih, H., & Fraser, I. S. (2007) · Cited by 1
Self-citationSemi-invasive Diagnosis of Endometriosis Doctoral Thesis
Bokor, A. (2010) · Cited by 1
Does postoperative pain predict the outcome of endometrial ablation?
Yuan, X., Richmond, M. N., Leng, Y., & Li, T. C. (2013) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12064 · Cited by 1
Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis
Fraser, I. S., Tokushige, N., Hey‐Cunningham, A. J., Berbic, M., & Ng, C. H. M. (2011) · doi:10.1002/9781444398519.ch21 · Cited by 1
Self-citationEndometriosis in the Adolescent Patient
Templeman, C. E. (2011) · Wiley eBooks · doi:10.1002/9781444398519.ch54 · Cited by 1
Ersoy, B. (2015) · The Sydney eScholarship Repository (The University of Sydney) · Cited by 1
Autonomic denervation and the origins of chronic Western diseases
Quinn, M. J. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.11.022 · Cited by 1
Role of Nerve Fibres in Endometriosis
Tokushige, N. (2014) · Springer eBooks · doi:10.1007/978-4-431-54421-0_13
Self-citationde Arellano, M. L. B., Fiebitz, A., Arnold, J., Schneider, A., & Mechsner, S. (2010) · Der Gynäkologe · doi:10.1007/s00129-010-2589-2
Endometriosis and Cancer: Is There an Association?
Vega, M. G., Soto, E., & Goldberg, J. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-17849-3_5
Pain related genes in endometriosis: A meta-analysis
Saxena, M. (2015) · The Sydney eScholarship Repository (The University of Sydney)
Endometriosis en la adolescente
Templeman, C. E. (2009) · Clínicas obstétricas y ginecológicas de Norteamérica
Analyse von Nervenfasern und Nervenwachstumsfaktoren in der Adenomyose
Wagner, F. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-5948
Breen, J. (2010) · Rutgers University Community Repository (Rutgers University) · doi:10.7282/t30v8cxd
Al‐Jefout, M. (2016) · Jordan Medical Journal
Rectovaginal endometriosis : pain treatment options
Tarjanne, S. (2016) · Työväentutkimus Vuosikirja
Makari, S. D., Švedas, E., Railaitė, D. R., & Čižauskas, A. (2012)
de Ziegler, D., Streuli, I., Gayet, V., Bajouh, U., Berdah, J., & Chapron, C. (2012) · Informa Healthcare eBooks · doi:10.3109/9781841849737.045
Medical Treatment of Chronic Pelvic Pain
Gillett, W. R., & Jones, D. (2014) · Springer eBooks · doi:10.1007/978-3-319-12406-3_10
Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine
Zhang, X., Lu, B., Huang, X., Xu, H., Zhou, C., & Lin, J. (2009)
Proteomic identification of neurotrophins in the eutopic endometrium of women with
Browne, S., Yu, J., & Huang, R. (2012)
“Endometriosis”: A neuro-etiologic framework for its causes and consequences
Xin, Y. B., Hao, G. N., Lan, J. J., Xu, H., Juan, Z. H., & Mj, Q. (2019) · Clinical Obstetrics Gynecology and Reproductive Medicine · doi:10.15761/cogrm.1000262
Canis, M. J., Matsuzaki, S., Rivoire, C., Jardon, K., Tamburro, S., Rabischong, B., & Mage, G. (2007)
Small fiber involvement in Fabry's disease
He, L. (2009) · Online Publication Service of Würzburg University (Würzburg University)
Étude anatomique et immunohistochimique de l’innervation utérine
Pinsard, M., Bellaud, P., Mouchet, N., Fautrel, A., Lévêque, J., Lavoué, V., Morandi, X., & Timoh, K. N. (2021) · Morphologie · doi:10.1016/j.morpho.2021.05.087
Gonçalves, D. M. R. (2018) · doi:10.47749/t/unicamp.2018.1058125
FRONTEIRAS DO CONHECIMENTO EM EXERCÍCIO FÍSICO
Dantas, E. H. M., Lessa, V. V. S., Cortez, A. C. L., Alves, J. C. C., Dessimoni, E. S., Vorkapic, C. F., Coelho, R. R., & Dantas, K. B. A. (2022) · Bookerfield Editora · doi:10.53268/bkf22040502
PHAGE DISPLAY NO DESENVOLVIMENTO DE BIOSSENSORES APLICADOS À ONCOLOGIA
Alves, R. D. F., Martins, I. C., Ribeiro, M. A., Sotomayor, M. D. P. T., & Araújo, T. G. (2022) · Bookerfield Editora · doi:10.53268/bkf22040508
O USO DE LUTEÍNA E ZEAXANTINA COMO CORANTES INTRAOCULARES PARA CIRURGIA OFTALMOLÓGICA
Martins, D. S. (2022) · Bookerfield Editora · doi:10.53268/bkf22040506
CIRURGIA DA FIBRILAÇÃO ATRIAL CRÔNICA COM ULTRASSOM EM PACIENTES COM LESÃO VALVAR MITRAL: PARTE I
Brick, A. V., & Braile, D. M. (2022) · Bookerfield Editora · doi:10.53268/bkf22040503
Kaizer, L. D., de Oliveira, L. S., Furlan, S., Carlin, M. P., & de Castro, L. F. (2022) · Bookerfield Editora · doi:10.53268/bkf22040507
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Brick, A. V., & Braile, D. M. (2022) · Bookerfield Editora · doi:10.53268/bkf22040504
EVOLUÇÃO DO ENSINO DE ANATOMIA
da Silva, R. W., de Godoy, J. R. P., & Longatti, S. C. (2022) · Bookerfield Editora · doi:10.53268/bkf22040501
Gentilini, J. (2022) · Bookerfield Editora · doi:10.53268/bkf22040510
Margatho, D., Carvalho, N. M., & Bahamondes, L. G. (2022) · Bookerfield Editora · doi:10.53268/bkf22040509
(2011) · Elsevier eBooks · doi:10.1016/b978-0-7295-3804-6.50059-3
Tomita, T. (2023) · Medical Research Archives · doi:10.18103/mra.v11i6.3884
Neuroimmunology of Endometriosis-Associated Pain and Its Psychological Aspects
Lin, Y., & Wang, C. C. (2024) · Integrated science · doi:10.1007/978-3-031-72079-6_30
Bashir, S. T., Redden, C. R., Raj, K., Arcanjo, R. B., Stasiak, S., Li, Q., Steelman, A. J., & Nowak, R. A. (2024) · Figshare · doi:10.6084/m9.figshare.26572954
Nerve fibers in endometriosis: pain pathogenesis and new approaches to diagnosis
Adamyan, L. V., Мусабиевна, С. М., Paklina, O. V., Karapetyan, E. A., & Arslanyan, K. N. (2026) · Russian Journal of Human Reproduction · doi:10.17116/repro20263202154
Neuropeptides in endometriosis-associated pain: a review
Polenghi, G., Fiore, A., Casalechi, M., Viganò, P., & Tapmeier, T. T. (2026) · Journal of Endometriosis and Uterine Disorders · doi:10.1016/j.jeud.2026.100186
Metadata
- Authors
- Tokushige, N., Markham, R., Russell, P., & Fraser, I. S.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Tokushige, Natsuko
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 88
- Issue
- 4
- Pages
- 795-803
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1994988244
- Cited by
- 151
- References
- 67
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 13 · 2014: 9 · 2013: 11 · 2012: 9
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Plant and fungal interactions
- Keywords
- endometriosis, endometrium, myometrium, nerve fiber density, adrenergic nerve fibers, cholinergic fibers, PGP 9.5, neurofilaments, substance P, calcitonin gene-related peptide, tyrosine hydroxylase, vesicular acetylcholine transporter, neuropeptides, endometriosis-associated pain, eutopic endometrium
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Hysterectomy, Immunohistochemistry, Myometrium, Nerve Fibers
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