Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids
Open accessAbstract
To determine whether nerve fibers in the functional layer endometrium are caused by an endometriosis itself or a common symptom of pain, endometrial tissues from 30 women with endometriosis, 40 women with adenomyosis, 41 women with uterine fibroids, and 47 endometriosis women with adenomyosis were stained immunohistochemically using the highly specific polyclonal rabbit antiprotein gene product 9.5 (PGP9.5) and monoclonal mouse antineurofilament protein. We demonstrated PGP9.5-immunoactive nerve fibers in the functional layer of endometrium in women with pain symptoms, but not in women without pain symptoms, whether the women had endometriosis, adenomyosis, uterine fibroids, or endometriosis with adenomyosis, suggesting a role of PGP9.5-immunoactive nerve fibers in the functional layer of the endometrium playing in pain generation in these disorders.
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Increased nerve growth in the myometrium has been reported in women with pain, with or without endometriosis, compared with healthy women.
“Others report increased nerve growth in myometrium in those with pain with or without endometriosis compared with healthy women”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Zhang et al., 2009
The Abstract reports nerve fibers in the functional layer of the endometrium in women with pain, with or without endometriosis, but not in women without pain. It does not establish the claimed increase in the myometrium or make a comparison with healthy women. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHow endometrial nerves relate specifically to endometriosis-associated pain is currently unknown, because nerve fibers occur in the uterus of women with pain who do not have endometriosis.
“Currently, however, how endometrial nerves relate to pain specifically associated with endometriosis is unknown because nerve fibers have been found in the uterus of women with pain who do not have endometriosis”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Zhang et al., 2009
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Cites
Revised American Society for Reproductive Medicine classification of endometriosis: 1996
American Society for Reproductive Medicine (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81391-x · Cited by 3,018 · see citing works
Relationship between endometriotic foci and nerves in rectovaginal endometriotic nodules
Anaf, V. (2000) · Human Reproduction · doi:10.1093/humrep/15.8.1744 · Cited by 333 · see citing works
Nerve fibres in peritoneal endometriosis
Tokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2006) · Human Reproduction · doi:10.1093/humrep/del260 · Cited by 299 · see citing works
Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis
Anaf, V., Chapron, C., El Nakadi, I., De Moor, V., Simonart, T., & Noël, J.-C. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.03.057 · Cited by 258 · see citing works
Tokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2006) · Human Reproduction · doi:10.1093/humrep/dei368 · Cited by 236 · see citing works
Rich innervation of deep infiltrating endometriosis
Wang, G., Tokushige, N., Markham, R., & Fraser, I. S. (2008) · Human Reproduction · doi:10.1093/humrep/den464 · Cited by 232 · see citing works
Clinical presentation of fibroids
Gupta, S., Jose, J., & Manyonda, I. (2008) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2008.01.008 · Cited by 217 · see citing works
Presence and Distribution of Sensory Nerve Fibers in Human Peritoneal Adhesions
Sulaiman, H., Gabella, G., Davis, C., Mutsaers, S. E., Boulos, P. B., Laurent, G. J., & Herrick, S. E. (2001) · Annals of Surgery · doi:10.1097/00000658-200108000-00016 · Cited by 159 · see citing works
Reproductive performance in infertile women with rectovaginal endometriosis: Is surgery worthwhile?
Vercellini, P., Pietropaolo, G., Giorgi, O. D., Daguati, R., Pasin, R., & Crosignani, P. G. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.03.068 · Cited by 154 · see citing works
Uterine fibroid tumors: diagnosis and treatment.
Evans, P., & Brunsell, S. (2007) · PubMed · Cited by 152 · see citing works
Tokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.078 · Cited by 151 · see citing works
Mechsner, S., Schwarz, J., Thode, J., Loddenkemper, C., Salomon, D. S., & Ebert, A. D. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.087 · Cited by 114 · see citing works
Mechsner, S., Kaiser, A., Kopf, A., Gericke, C., Ebert, A., & Bartley, J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.006 · Cited by 107 · see citing works
Innervation of endometrium and myometrium in women with painful adenomyosis and uterine fibroids
Zhang, X., Lu, B., Huang, X., Xu, H., Zhou, C., & Lin, J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.03.026 · Cited by 100 · see citing works
Self-citationTokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.08.074 · Cited by 85 · see citing works
Adenomyosis: prevalence, risk factors, symptoms and clinical findings.
Yeniel, Ö., Çırpan, T., Ulukuş, M., Özbal, A., Gündem, G., Özşener, S., Zekioğlu, O., & Yilmaz, H. (2007) · PubMed · Cited by 81 · see citing works
Tamburro, S., Canis, M., Albuisson, E., Dechelotte, P., Darcha, C., & Mage, G. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01182-8 · Cited by 79 · see citing works
Uterine innervation after hysterectomy for chronic pelvic pain with, and without, endometriosis
Atwal, G., du Plessis, D., Armstrong, G., Slade, R., & Quinn, M. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.05.035 · Cited by 78 · see citing works
Vincent, K. (2009) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.073494 · Cited by 73 · see citing works
Tulandi, T. (1998) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(98)00298-1 · Cited by 71 · see citing works
Al-Jefout, M., Andreadis, N., Tokushige, N., Markham, R., & Fraser, I. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.04.032 · Cited by 68 · see citing works
Evans, S., Moalem‐Taylor, G., & Tracey, D. J. (2007) · Pain · doi:10.1016/j.pain.2007.07.006 · Cited by 68 · see citing works
Uterine innervation in adenomyosis
Quinn, M. J. (2007) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610701213976 · Cited by 61 · see citing works
Nerve Fibers and Histopathology of Endometriosis-Harboring Peritoneum
Tulandi, T., Felemban, A., & Fong Chen, M. (2001) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(05)60556-7 · Cited by 60 · see citing works
Ortiz, D. (2008) · PubMed · Cited by 41 · see citing works
Uterine innervation in fibroids: A qualitative study
Quinn, M. J. (2007) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610701405697 · Cited by 21 · see citing works
Endometrial nerve fiber proliferation in “endometriosis”
Quinn, M. J. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.02.041 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 28 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Evans S, Moalem-Taylor G, Tracey DJ. Pain and en- dometriosis. Pain 2007;132:S22-5.
Cited by
Sorted by citations
Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications
Stratton, P., & Berkley, K. J. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq050 · Cited by 442 · see citing works
Pathogenesis of adenomyosis, an update on molecular mechanisms
Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.016 · Cited by 326 · see citing works
Adenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 331 · see citing works
Mechanisms of pain in endometriosis
Morotti, M., Vincent, K., & Becker, C. M. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.07.497 · Cited by 255 · see citing works
Structural and molecular features of the endomyometrium in endometriosis and adenomyosis
Benagiano, G., Brosens, I., & Habiba, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt052 · Cited by 246 · see citing works
Endometrial alterations in endometriosis: a systematic review of putative biomarkers
May, K. E., Villar, J., Kirtley, S., Kennedy, S. H., & Becker, C. M. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr013 · Cited by 237 · see citing works
Peripheral changes in endometriosis-associated pain
Morotti, M., Vincent, K., Brawn, J., Zondervan, K. T., & Becker, C. M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu021 · Cited by 198 · see citing works
Endometrial biomarkers for the non-invasive diagnosis of endometriosis
Gupta, D., Hull, M. L., Fraser, I. S., Miller, L., Bossuyt, P. M., JOHNSON, N. P., & Nisenblat, V. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012165 · Cited by 174 · see citing works
Fassbender, A., Vodolazkaia, A., Saunders, P., Lebovic, D., Waelkens, E., De Moor, B., & D'Hooghe, T. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.01.097 · Cited by 150 · see citing works
Guo, S.-W., Mao, X., Ma, Q., & Liu, X. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.038 · Cited by 131 · see citing works
The eutopic endometrium in endometriosis: are the changes of clinical significance?
Brosens, I. A., Brosens, J. J., & Benagiano, G. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.01.022 · Cited by 124 · see citing works
Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects
Lessey, B., Lebovic, D., & Taylor, R. (2013) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1333476 · Cited by 113 · see citing works
Role of eutopic endometrium in pelvic endometriosis
Carvalho, L., Podgaec, S., Bellodi-Privato, M., Falcone, T., & Abrão, M. S. (2011) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2011.03.009 · Cited by 99 · see citing works
He, W., Liu, X., Zhang, Y., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110381927 · Cited by 96 · see citing works
Primary Dysmenorrhea: An Urgent Mandate
Ballantyne, J. C., & Cousins, M. J. (2013) · Cited by 88 · see citing works
Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology
Guo, S. (2022) · Reproduction · doi:10.1530/rep-22-0224 · Cited by 79 · see citing works
Proteomic identification of neurotrophins in the eutopic endometrium of women with endometriosis
Browne, A. S., Yu, J., Huang, R.-P., Francisco, A. M. C., Sidell, N., & Taylor, R. N. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.05.027 · Cited by 78 · see citing works
The Endometrium in Adenomyosis
Benagiano, G., & Brosens, I. A. (2012) · Women s Health · doi:10.2217/whe.12.8 · Cited by 73 · see citing works
Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis
Zhang, X., Yao, H., Huang, X., Lü, B., Xu, H., & Zhou, C. (2009) · Human Reproduction · doi:10.1093/humrep/dep427 · Cited by 72 · see citing works
Self-citationLiu, X., Nie, J., & Guo, S. (2010) · Human Reproduction · doi:10.1093/humrep/deq311 · Cited by 68 · see citing works
Angiogenesis lymphangiogenesis and neurogenesis in endometriosis
Hey‐Cunningham, A. J. (2013) · Frontiers in Bioscience-Elite · doi:10.2741/e682 · Cited by 68 · see citing works
Endometriosis: a life cycle approach?
Brosens, I., Puttemans, P., & Benagiano, G. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.03.009 · Cited by 66 · see citing works
Mast cells in chronic inflammation, pelvic pain and depression in women
Graziottin, A., Skaper, S. D., & Fusco, M. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.911280 · Cited by 63 · see citing works
Anti-platelet therapy holds promises in treating adenomyosis: experimental evidence
Zhu, B., Chen, Y., Shen, X., Liu, X., & Guo, S. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0198-1 · Cited by 61 · see citing works
Non-invasive diagnosis of endometriosis: the goal or own goal?
Somigliana, E., Vercellini, P., Viganò, P., Benaglia, L., Crosignani, P. G., & Fedele, L. (2010) · Human Reproduction · doi:10.1093/humrep/deq141 · Cited by 55 · see citing works
P2X3 receptor involvement in endometriosis pain via ERK signaling pathway
Ding, S., Zhu, L., Tian, Y., Zhu, T., Huang, X., & Zhang, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184647 · Cited by 55 · see citing works
Self-citationCurrent Challenges in the Management of Chronic Pelvic Pain in Women: From Bench to Bedside
Siqueira-Campos, V. M., de Deus, M. S. C., Poli-Neto, O. B., Silva, J. C. R. E., de Deus, J. M., & Conde, D. M. (2022) · International Journal of Women s Health · doi:10.2147/ijwh.s224891 · Cited by 53 · see citing works
O, D. F., Flores, I., Waelkens, E., & D’Hooghe, T. M. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.04.001 · Cited by 53 · see citing works
Influence of Nerve Growth Factor in Endometriosis-Associated Symptoms
Barcena, M. L., Arnold, J., Vercellino, G. F., Chiàntera, V., Ebert, A. D., Schneider, A., & Mechsner, S. (2011) · Reproductive Sciences · doi:10.1177/1933719111410711 · Cited by 53 · see citing works
Effect of A-317491 delivered by glycolipid-like polymer micelles on endometriosis pain
Yuan, M., Ding, S., Meng, T., Lu, B., Shao, S., Zhang, X., Yuan, H., & Hu, F. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s146569 · Cited by 52 · see citing works
Self-citationThe Importance of Pelvic Nerve Fibers in Endometriosis
Miller, E. J., & Fraser, I. S. (2015) · Women s Health · doi:10.2217/whe.15.47 · Cited by 52 · see citing works
Progestin Therapy in Endometriosis
Gezer, A., & Oral, E. (2015) · Women s Health · doi:10.2217/whe.15.42 · Cited by 50 · see citing works
Yan, D., Liu, X., & Guo, S. (2016) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.06.017 · Cited by 48 · see citing works
Expression of neuronal markers in the endometrium of women with and those without endometriosis
Newman, T. A., Bailey, J. L., Stocker, L. J., Woo, Y. L., Macklon, N., & Cheong, Y. C. (2013) · Human Reproduction · doi:10.1093/humrep/det274 · Cited by 42 · see citing works
Zhao, T., Liu, X., Zhen, X., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110381928 · Cited by 41 · see citing works
Moving Toward Individualized Medicine for Uterine Leiomyomas
Laughlin-Tommaso, S. K., & Stewart, E. A. (2018) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002785 · Cited by 41 · see citing works
Lin, X. L., Hai, N., Zhang, J., Han, Z. Y., Yu, J., Liu, F. Y., Dong, X. J., & Liang, P. (2020) · International Journal of Hyperthermia · doi:10.1080/02656736.2019.1708481 · Cited by 41 · see citing works
Remodeling of estrogen-dependent sympathetic nerve fibers seems to be disturbed in adenomyosis
Barcena, M. L., Oldeweme, J., Arnold, J., Schneider, A., & Mechsner, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.013 · Cited by 40 · see citing works
Anatomic Sites and Associated Clinical Factors for Deep Dyspareunia
Yong, P. J., Williams, C., Yosef, A. H., Wong, F., Bedaiwy, M. A., Lisonkova, S., & Allaire, C. (2017) · Sexual Medicine · doi:10.1016/j.esxm.2017.07.001 · Cited by 39 · see citing works
Taylor, H. S., Dun, E. C., & Chwalisz, K. (2019) · Pain Management · doi:10.2217/pmt-2019-0010 · Cited by 38 · see citing works
Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis
İlhan, M., Dereli, F. T. G., & Akkol, E. K. (2018) · Current Drug Delivery · doi:10.2174/1567201816666181227112421 · Cited by 36 · see citing works
Diagnosis of endometrial nerve fibers in women with endometriosis
Aghaey Meibody, F., Mehdizadeh Kashi, A., Zare Mirzaie, A., Ghajarie Bani Amam, M., Shariati Behbahani, A., Zolali, B., & Najafi, L. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1806-5 · Cited by 35 · see citing works
Endometriosis: the consequence of uterine denervation–reinnervation
Quinn, M. J. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-011-2063-y · Cited by 35 · see citing works
Ellett, L., Readman, E., Newman, M. R., McIlwaine, K., Villegas, R., Jagasia, N., & Maher, P. J. (2015) · Human Reproduction · doi:10.1093/humrep/dev259 · Cited by 33 · see citing works
New paradigms in the diagnosis and management of endometriosis
Kavoussi, S. K., Lim, C. S., Skinner, B. D., Lebovic, D. I., & As‐Sanie, S. (2016) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000288 · Cited by 33 · see citing works
Clinical Characteristics and Local Histopathological Modulators of Endometriosis and Its Progression
Istrate-Ofiţeru, A.-M., Mogoantă, C. A., Zorilă, G. L., Roşu, G. C., Drăguşin, R. C., Berbecaru, E.-I.-A., Zorilă, M. V., Comănescu, C. M., Mogoantă, S. Ş., Văduva, C.-C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031789 · Cited by 31 · see citing works
Chen, Y., Zhu, B., Zhang, H., Ding, D., Liu, X., & Guo, S. (2014) · Reproductive Sciences · doi:10.1177/1933719113518984 · Cited by 28 · see citing works
Guo, S., Habiba, M. A., & Benagiano, G. (2023) · Biomolecules · doi:10.3390/biom13020336 · Cited by 29 · see citing works
Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis
Choi, Y. S., Cho, S., Lim, K. J., Jeon, Y. E., Yang, H. I., Lee, K. E., Heena, K., Seo, S. K., Kim, H. Y., & Lee, B. S. (2010) · Growth Factors · doi:10.3109/08977194.2010.511619 · Cited by 28 · see citing works
The new application of mifepristone in the relief of adenomyosis-caused dysmenorrhea
Che, X., Wang, J., He, J., Guo, X., Li, T., & Zhang, X. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.39252 · Cited by 27 · see citing works
Self-citationThe Autonomic Innervation and Uterine Telocyte Interplay in Leiomyoma Formation
Aleksandrovych, V., Kurnik‐Łucka, M., Bereza, T., Białas, M. B., Pasternak, A., Crețoiu, D., Walocha, J. A., & Gil, K. (2019) · Cell Transplantation · doi:10.1177/0963689719833303 · Cited by 24 · see citing works
Is the Detection of Endometrial Nerve Fibers Useful in the Diagnosis of Endometriosis?
Leslie, C., Ma, T., McElhinney, B., Leake, R., & Stewart, C. J. R. (2013) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e31825b0585 · Cited by 23 · see citing works
Eutopic endometrium from women with endometriosis does not exhibit neurotrophic properties
Barcena, M. L., Arnold, J., Sacher, F., Bloechle, M., Staube, M., Bartley, J., Vercellino, G. F., Chiàntera, V., Schneider, A., & Mechsner, S. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.04.020 · Cited by 23 · see citing works
Nerve fiber density in deep nodular endometriotic lesions induced in a baboon experimental model
Donnez, O., Soares, M. P. M., Defrère, S., Dehoux, J., Langendonckt, A. V., Donnez, J., Dolmans, M., & Colette, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.06.014 · Cited by 23 · see citing works
Ultrastructural Features of Eutopic Endometrium in a Rat Model of Endometriosis
Elgamal, D. A., Othman, E. R., & Ahmed, S. (2015) · Journal of Microscopy and Ultrastructure · doi:10.1016/j.jmau.2015.10.002 · Cited by 20 · see citing works
Caldesmon: New Insights for Diagnosing Endometriosis1
Meola, J., Hidalgo, G. D. S., Silva, J. C. R. E., da Silva, L. E. C. M., de Paz, C. C. P., & Ferriani, R. A. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.112.103598 · Cited by 20 · see citing works
Zevallos, H. B. V., McKinnon, B. D., Tokushige, N., Mueller, M. D., Fraser, I. S., & Bersinger, N. A. (2014) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3379-1 · Cited by 18 · see citing works
The Role of Platelets in the Pathogenesis and Pathophysiology of Adenomyosis
Guo, S. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12030842 · Cited by 17 · see citing works
Neurotrophin Expression Is Not Affected in Uteri of Women with Adenomyosis
Barcena, M. L., Wagner, M. F., Oldeweme, J., Arnold, J., Ebert, A. D., Schneider, A., & Mechsner, S. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9757-x · Cited by 17 · see citing works
Donnez, O., Soares, M. P. M., Defrère, S., Kerk, O. V., Langendonckt, A. V., Donnez, J., Dolmans, M., & Colette, S. (2013) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000155 · Cited by 17 · see citing works
Biomarker development in endometriosis
Burney, R. O. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.936692 · Cited by 16 · see citing works
Pathophysiology of pain in patients with peritoneal endometriosis
Ferrero, S., Vellone, V. G., & Barra, F. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.01.36 · Cited by 16 · see citing works
DRG Neurons Promote Perineural Invasion of Endometrial Cancer via GluR2
Ni, T., Huang, T., Gu, S., Wang, J., Liu, Y., Sun, X. G., & Wang, Y. (2020) · Journal of Cancer · doi:10.7150/jca.40055 · Cited by 15 · see citing works
Update of recent studies of adenomyosis-associated dysmenorrhea
Jiang, C., & Cheng, Z. (2016) · Gynecology and Minimally Invasive Therapy · doi:10.1016/j.gmit.2016.06.002 · Cited by 14 · see citing works
Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis
Miyashita‐Ishiwata, M., Koga, K., Takeuchi, A., Makabe, T., Taguchi, A., Urata, Y., Izumi, G., Takamura, M., Harada, M., Hirata, T., et al. (2018) · Reproductive Sciences · doi:10.1177/1933719118806395 · Cited by 14 · see citing works
Innervation in women with uterine myoma and adenomyosis
Choi, Y. J., Chang, J.-A., Kim, Y. A., Chang, S. H., Chun, K., & Koh, J. W. (2015) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2015.58.2.150 · Cited by 14 · see citing works
Whitehill, K., Yong, P. J., & Williams, C. (2012) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)35271-9 · Cited by 14 · see citing works
Deep dyspareunia: a narrative review of impact on sexual function and quality of life
Yong, P. J. (2022) · Minerva Obstetrics and Gynecology · doi:10.23736/s2724-606x.22.04974-0 · Cited by 10 · see citing works
Çetin, C., Serdaroğlu, H., & Tuzlalı, S. (2013) · Europe PMC (PubMed Central) · Cited by 9 · see citing works
Giray, B., Büyükbayrak, E. E., Keser, S. H., Karşıdağ, A. Y. K., & Türkgeldi, A. (2018) · Geburtshilfe und Frauenheilkunde · doi:10.1055/a-0591-1751 · Cited by 8 · see citing works
Influence of endometrial nerve fibers and hormones on pain in women with endometriosis
Sommar, A., Bahat, P. Y., Özaydin, I. Y., Bixo, M., Bäckström, T. C., Oral, E., & Türkmen, Ş. (2025) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2025.113950 · Cited by 7 · see citing works
A modest proposal to investigate chronic uterine pain
Tu, F., & As‐Sanie, S. (2016) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14393 · Cited by 7 · see citing works
Ghersa, F., Delsouc, M. B., Goyeneche, A. A., Vallcaneras, S. S., Meresman, G. F., Telleria, C. M., & Casais, M. (2019) · Molecular Human Reproduction · doi:10.1093/molehr/gaz026 · Cited by 6 · see citing works
Lee, C. E., Allaire, C., Williams, C., Bedaiwy, M. A., Noga, H. L., Hanley, G. E., Lisonkova, S., Albert, A., & Yong, P. J. (2024) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2023.102246 · Cited by 5 · see citing works
Drug development for adenomyosis based on pathophysiology
Guo, S. (2025) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.16322 · Cited by 4 · see citing works
Ye, Z., Zhao, A., Li, X., Hao, Y., Huang, D., Chen, J., Li, T., Dai, Y., Sun, W., Ma, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202507128 · Cited by 6 · see citing works
Vieira, M. D. C., Andres, M. P., Riccio, L. G. C., Schlindwein, S. S., Arcoverde, F. V. L., Sardo, A. D. S., & Abrão, M. S. (2024) · Reproductive Sciences · doi:10.1007/s43032-024-01587-8 · Cited by 4 · see citing works
Increased Nerve Fibers in Placental Bed Myometrium in Women With Preeclampsia
Fan, R., Qiu, L., Huang, X., Chen, Z., Xu, H., Zhou, C., & Zhang, X. (2011) · Reproductive Sciences · doi:10.1177/1933719111411730 · Cited by 4 · see citing works
Self-citationDetection of Endometrial Nerve Fibres – a Novel Technique to Diagnose Endometriosis
Yadav, G., Radhakrishnan, G., Singh, N., & Radhika, A. G. (2013) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000166 · Cited by 3 · see citing works
Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways
Olteanu, I.-L., Pușcașu, C., Andrei, C., & Zanfirescu, A. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48050528 · Cited by 2 · see citing works
Adamyan, L. V., Sokolov, A. D., Arakelyan, A. S., Станиславовна, Б. А., & Asaturova, A. V. (2025) · Russian Journal of Human Reproduction · doi:10.17116/repro20253101135 · Cited by 2 · see citing works
An integrated approach to the treatment of pelvic pain associated with adenomyosis
Татарчук, Т. Ф., Kaluginа, L. V., Danylova, A. О., & Pavlova, K. S. (2021) · Reproductive Endocrinology · doi:10.18370/2309-4117.2021.59.53-60 · Cited by 2 · see citing works
The Endometrium in Adenomyosis
Habiba, M. A., & Benagiano, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-13012-5_6 · Cited by 2 · see citing works
Endometrial nerve fibre density in patients undergoing IVF: a pilot study
Wand, S., Weissman, A., Sagiv, R., Schreiber, L., Boaz, M., Horowitz, E., Ravhon, A., Seadia, S., Barkat, J., Golan, A., et al. (2014) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2014.02.007 · Cited by 1 · see citing works
Scoring of Endometriosis: Relation to Nerve Fiber Density in Endometrial Biopsy
Hemeda, H., El‐Shourbagy, M., Nasr-addin, M. A., El-Refaee, T. A., Ahmed, A. A., & Awad, N. M. (2015) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000217 · Cited by 1 · see citing works
Hormonal Therapy in Endometriosis and Adenomyosis: Progestins
Darıcı, E., & Oral, E. (2022) · Springer eBooks · doi:10.1007/978-3-030-97236-3_41 · Cited by 1 · see citing works
Assisted Reproductive Technique Complications in Pregnancy
Kosmas, I. P., Tatsi, C., Sifakis, S., Tzabari, A., Kiortsis, D. N., Mynbaev, O. A., Baldini, D., & Malvası, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-31377-1_10 · Cited by 1 · see citing works
Comparative analysis of eutopic endometrium from women with and without endometriosis
Adamyan, L. V., Aznaurova, Y. B., & Osipova, A. A. (2018) · Russian Journal of Human Reproduction · doi:10.17116/repro201824310 · Cited by 1 · see citing works
Ersoy, B. (2015) · The Sydney eScholarship Repository (The University of Sydney) · Cited by 1 · see citing works
de Arellano, M. L. B., Fiebitz, A., Arnold, J., Schneider, A., & Mechsner, S. (2010) · Der Gynäkologe · doi:10.1007/s00129-010-2589-2
Pain related genes in endometriosis: A meta-analysis
Saxena, M. (2015) · The Sydney eScholarship Repository (The University of Sydney)
Analyse von Nervenfasern und Nervenwachstumsfaktoren in der Adenomyose
Wagner, F. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-5948
Venegas, S., Parada, E., Boric, M. A., Hugo Sovino, S., Fuentes, A., Gabler, F., González-Ramos, R., & Johnson, M. C. (2015) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2015.57060
Makari, S. D., Švedas, E., Railaitė, D. R., & Čižauskas, A. (2012)
Proteomic identification of neurotrophins in the eutopic endometrium of women with
Browne, S., Yu, J., & Huang, R. (2012)
Hysterectomy in the Surgical Management of Endometriosis
Murtada, R., Centini, G., Afors, K., & Wattiez, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-22497-8_48
Hendry, D. (2019) · Andalas obstetrics and gynecology journal · doi:10.25077/aogj.1.1.31-38.2017
Makari, S. D., Švedas, E., Railaitė, D. R., Čižauskas, A., & Makari, J. (2012)
Hendry, D., Madjid, T. H., Anwar, R., & Rachmawati, A. (2019) · Andalas obstetrics and gynecology journal · doi:10.25077/aoj.1.1.38-46.2017
- Authors
- Zhang, X., Lu, B., Huang, X., Xu, H., Zhou, C., & Lin, J.
- Affiliations
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Corresponding author
- Zhang, Xinmei
- Lin, Jun
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 92
- Issue
- 5
- Pages
- 1799-1801
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2079497712
- Cited by
- 110
- References
- 28
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 10 · 2014: 6 · 2013: 15 · 2012: 10
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- endometriosis, adenomyosis, uterine fibroids, PGP 9.5, neurofilament proteins, pelvic pain
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Leiomyoma, Middle Aged, Nerve Fibers, Peritoneal Diseases, Retrospective Studies, Uterine Neoplasms, Pelvic Pain, Ubiquitin Thiolesterase
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