Transforming growth factor (TGF)-β1-induced human endometrial stromal cell decidualization through extracellular signal-regulated kinase and Smad activation in vitro: peroxisome proliferator-activated receptor gamma acts as a negative regulator of TGF-β1

CYCLOOXYGENASES 1 AND 2

Vane, J. R., Bakhle, Y. S., & Botting, R. M. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.97 · Cited by 2,737 · see citing works

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,386 · see citing works

Reproductive endocrinology, surgery, and technology

Adashi, E. Y., Rock, J. A., & Rosenwaks, Z. (1996) · Medical Entomology and Zoology · Cited by 503 · see citing works

Antineoplastic effects of peroxisome proliferatoractivated receptor γ agonists

Grommes, C., Landreth, G. E., & Heneka, M. T. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01509-8 · Cited by 440 · see citing works

Reproductive Endocrinology, Surgery and Technology

Thompson, I. E. (1997) · JAMA · doi:10.1001/jama.1997.03540400080045 · Cited by 433 · see citing works

PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer

Murphy, G. J., & Holder, J. C. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01559-5 · Cited by 386 · see citing works

Adipogenesis: forces that tip the scales

MacDougald, O. A., & Mandrup, S. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00517-3 · Cited by 355 · see citing works

PPARγ agonists inhibit TGF-β induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis

Burgess, H. A., Daugherty, L. E., Thatcher, T. H., Lakatos, H. F., Ray, D. M., Redonnet, M. R., Phipps, R. P., & Sime, P. J. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00383.2004 · Cited by 318 · see citing works

TGF-beta: problems and prospects.

Sporn, M. B., & Roberts, A. B. (1990) · Cell Regulation · doi:10.1091/mbc.1.12.875 · Cited by 259 · see citing works

Hormonal regulation of human endometrial stromal cells in culture: an in vitro model for decidualization

Irwin, J. C., Kirk, D., King, R. J. B., Quigley, M. M., & Gwatkin, R. B. L. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)61028-2 · Cited by 248 · see citing works

Prolactin production by human endometrium during the normal menstrual cycle

Maslar, I. A., & Riddick, D. H. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90386-7 · Cited by 244 · see citing works

v-src Induction of the TIS10/PGS2 Prostaglandin Synthase Gene Is Mediated by an ATF/CRE Transcription Response Element

Xie, W., Fletcher, B. S., Andersen, R. D., & Herschman, H. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6531 · Cited by 205 · see citing works

Regulation of Prolactin Production by Progestin, Estrogen, and Relaxin in Human Endometrial Stromal Cells*

HUANG, J. R., Tseng, L., BISCHOF, P., & Jänne, O. A. (1987) · Endocrinology · doi:10.1210/endo-121-6-2011 · Cited by 197 · see citing works

The control of prostaglandin production by the endometrium in relation to luteolysis and menstruation

Poyser, N. L. (1995) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(95)90115-9 · Cited by 163 · see citing works

Prostaglandin E2 enhances human endometrial stromal cell differentiation

Frank, G. R., Brar, A. K., Cedars, M. I., & Handwerger, S. (1994) · Endocrinology · doi:10.1210/endo.134.1.7506205 · Cited by 150 · see citing works

Cyclic adenosine 3',5'-monophosphate induces prolactin expression in stromal cells isolated from human proliferative endometrium.

Tang, B., Guller, S. M., & Gurpide, E. (1993) · Endocrinology · doi:10.1210/endo.133.5.8404671 · Cited by 124 · see citing works

Direct effect of gonadotropins on decidualization of human endometrial stromal cells

Tang, B., & Gurpide, E. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90064-4 · Cited by 122 · see citing works

Progesterone-dependent release of transforming growth factor-beta1 from epithelial cells enhances the endometrial decidualization by turning on the Smad signalling in stromal cells

Kim, M. R., Park, D. W., Lee, J. H., Choi, D. S., Hwang, K. J., Ryu, H., & Min, C. K. (2005) · Molecular Human Reproduction · doi:10.1093/molehr/gah240 · Cited by 104 · see citing works

PPAR $$\upgamma$$ represses VEGF expression in human endometrial cells: Implications for uterine angiogenesis

Peeters, L. L. H., Vigne, J., Tee, M. K., Zhao, D., Waite, L. L., & Taylor, R. N. (2006) · Angiogenesis · doi:10.1007/s10456-005-9027-4 · Cited by 96 · see citing works

Interleukin-1 Induces the Expression of Insulin-Like Growth Factor Binding Protein-1 during Decidualization in the Primate

Straková, Z., Srisuparp, S., & Fazleabas, A. T. (2000) · Endocrinology · doi:10.1210/endo.141.12.7810 · Cited by 87 · see citing works

Prostaglandins, Indomethacin and the Decidual Cell Reaction in the Mouse Uterus

Rankin, J. C., Ledford, B. E., Jonsson, H. T., & Baggett, B. (1979) · Biology of Reproduction · doi:10.1095/biolreprod20.2.399 · Cited by 80 · see citing works

A well-defined in vitro three-dimensional culture of human endometrium and its applicability to endometrial cancer invasion

Park, D. W., Choi, D. S., Ryu, H., Kwon, H. C., Joo, H., & Min, C. K. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00131-9 · Cited by 79 · see citing works

Mechanism of Human Endometrial Stromal Cells Decidualization

Tang, B., Guller, S. M., & Gurpide, E. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb21731.x · Cited by 62 · see citing works

Transforming Growth Factor β1 in the Human Endometrium. Cyclic Variation, Increased Expression by Estradiol and Progesterone, and Regulation of Plasminogen Activators and Plasminogen Activator Inhibitor-11

Casslén, B. G., Sandberg, T., Gustavsson, B., Wïllén, R., & Nilbert, M. C. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.6.1343 · Cited by 52 · see citing works

The 15-Deoxy-Δ12,14-prostaglandin J2Receptor, Peroxisome Proliferator Activated Receptor-γ (PPARγ) is Expressed in Human Gestational Tissues and is Functionally Active in JEG3 Choriocarcinoma Cells

Marvin, K. W., Eykholt, R. L., Keelan, J. A., Sato, T., & Mitchell, M. D. (2000) · Placenta · doi:10.1053/plac.1999.0485 · Cited by 51 · see citing works

Ultrastructural Changes in Human Endometrium at Different Phases of the Menstrual Cycle and Their Functional Significance

Verma, V. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000299412 · Cited by 47 · see citing works

Marker molecules of human endometrial differentiation can be hormonally regulated under in-vitro conditions as in-vivo

Classen-Linke, I. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.539 · Cited by 38 · see citing works

Retinoic acid induces expression of SLP-76: Expression with c-FMS enhances ERK activation and retinoic acid-induced differentiation/G0 arrest of HL-60 cells

Yen, A., Varvayanis, S. S., Smith, J. L., & Lamkin, T. J. (2005) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2005.09.020 · Cited by 22 · see citing works

The Endometrial Cycle

Ferenczy, A. S., & Mutter, G. L. (2008) · The Global Library of Women s Medicine · doi:10.3843/glowm.10293 · Cited by 18 · see citing works

Expression of Smad2 and Smad4, transforming growth factor-β signal transducers in rat endometrium during the estrous cycle, pre-, and peri-implantation

Lin, H., Wang, H., Li, Q., Liu, D., Zhang, X., Liu, G., Dong, Q., & Zhu, C. (2003) · Animal Reproduction Science · doi:10.1016/s0378-4320(03)00171-4 · Cited by 17 · see citing works

TGFβ superfamily signaling and uterine decidualization

Ni, N., & Li, Q. (2017) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-017-0303-0 · Cited by 89 · see citing works

Diverse Roles of Prostaglandins in Blastocyst Implantation

Salleh, N. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/968141 · Cited by 81 · see citing works

In vitro decidualisation of human endometrial stromal cells is enhanced by seminal fluid extracellular vesicles

Rodriguez‐Caro, H., Dragovic, R., Shen, M., Dombi, E., Mounce, G., Field, K., Meadows, J., Turner, K., Lunn, D., Child, T. J., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1565262 · Cited by 68 · see citing works

The Role of TGF-β during Pregnancy and Pregnancy Complications

Wen, B., Liao, H., Lin, W., Li, Z., Ma, X.-Q., Xu, Q., & Yu, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316882 · Cited by 54 · see citing works

Transforming Growth Factor-Beta 1 (TGF-B1) Liberation from Its Latent Complex During Embryo Implantation and Its Regulation by Estradiol in Mouse1

Maurya, V. K., Jha, R. K., Kumar, V., Joshi, A., Chadchan, S. B., Mohan, J. J., & Laloraya, M. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.112.106542 · Cited by 51 · see citing works

Single-cell analysis of prostaglandin E2-induced human decidual cell in vitro differentiation: a minimal ancestral deciduogenic signal

Stadtmauer, D. J., & Wagner, G. P. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab183 · Cited by 45 · see citing works

Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARγ and inhibiting TGFβ1

Qiao, H., Han, H., Hong, D., Ren, Z., Chen, Y., & Zhou, C. (2010) · Pharmaceutical Biology · doi:10.3109/13880209.2010.493179 · Cited by 45 · see citing works

Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells

Qi, Q., Liu, X., Zhang, Q., & Guo, S.-W. (2020) · Scientific Reports · doi:10.1038/s41598-020-57997-6 · Cited by 44 · see citing works

Roles of Estrogen Receptor-α and the Coactivator MED1 During Human Endometrial Decidualization

Kaya-Okur, H. S., Das, A., Taylor, R. N., Bagchi, I. C., & Bagchi, M. K. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1274 · Cited by 42 · see citing works

Differential microRNA Expression in Porcine Endometrium Involved in Remodeling and Angiogenesis That Contributes to Embryonic Implantation

Hong, L., Liu, R., Qiao, X., Wang, X., Wang, S., Li, J., Wu, Z., & Zhang, H. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00661 · Cited by 32 · see citing works

Paternal contributors in recurrent pregnancy loss: Cues from comparative proteome profiling of seminal extracellular vesicles

Jena, S. R., Nayak, J., Kumar, S., Kar, S., Dixit, A., & Samanta, L. (2020) · Molecular Reproduction and Development · doi:10.1002/mrd.23445 · Cited by 32 · see citing works

Dual role of TGF-β in early pregnancy: clues from tumor progression

Latifi, Z., Nejabati, H. R., Abroon, S., Mihanfar, A., Farzadi, L., Hakimi, P., Hajipour, H., Nouri, M., & Fattahi, A. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz024 · Cited by 31 · see citing works

Glucosamine Inhibits Decidualization of Human Endometrial Stromal Cells and Decreases Litter Sizes in Mice1

Tsai, J.-H., Schulte, M. B., O’Neill, K. E., Chi, M. M.-Y., Frolova, A. I., & Moley, K. H. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.108571 · Cited by 29 · see citing works

TGFβ1 Attenuates Expression of Prolactin and IGFBP-1 in Decidualized Endometrial Stromal Cells by Both SMAD-Dependent and SMAD-Independent Pathways

Kane, N. M., Jones, M. C., Brosens, J. J., KELLY, R. W., Saunders, P. T. K., & Critchley, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012970 · Cited by 26 · see citing works

Maternal Smad3 deficiency compromises decidualization in mice

Zhao, K., Lin, H., Zhu, C., Yang, X., & Wang, H. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24204 · Cited by 24 · see citing works

Telocytes enhanced the proliferation, adhesion and motility of endometrial stromal cells as mediated by the ERK pathway in vitro.

Tang, X.-L., Zhang, F.-L., Jiang, X., & Yang, X. (2019) · Europe PMC (PubMed Central) · Cited by 23 · see citing works

Endometrial Inflammation and Impaired Spontaneous Decidualization: Insights into the Pathogenesis of Adenomyosis

Kobayashi, H. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043762 · Cited by 22 · see citing works

Seminal plasma enhances and accelerates progesterone-induced decidualisation of human endometrial stromal cells

Doyle, Ú., Sampson, N., Zenzmaier, C., Schwärzler, P., & Berger, P. (2011) · Reproduction Fertility and Development · doi:10.1071/rd10296 · Cited by 18 · see citing works

Transforming growth factor beta signaling and decidual integrity in mice†

Fang, X. D., Ni, N., Gao, Y., Lydon, J. P., Ivanov, I. V., Rijnkels, M., Bayless, K. J., & Li, Q. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa155 · Cited by 17 · see citing works

Abnormal ciliogenesis in decidual stromal cells in recurrent miscarriage

Hassan, E., Kojima, R., Ozawa, F., Yoshihara, H., Goto, S., Kitaori, T., Inagaki, H., Kato, Y., & Sugiura‐Ogasawara, M. (2022) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2022.103486 · Cited by 16 · see citing works

Adenomyosis-associated infertility: an update of the immunological perspective

Cao, Y., Yang, D., Cai, S., Yang, L., Yu, S., Geng, Q., Mo, M., Li, W., Wei, Y., Li, Y., et al. (2024) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2024.104703 · Cited by 16 · see citing works

In vitro effects of peroxisome proliferator–activated receptor-γ ligands on gene expression in lipopolysaccharide-induced endometrial and endometriotic stromal cells

Sharma, I., Dhawan, V., Saha, S. C., & Dhaliwal, L. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.09.008 · Cited by 13 · see citing works

Evidence of inhibin/activin subunit betaC and betaE synthesis in normal human endometrial tissue

Mylonas, I. G., Brüning, A., Shabani, N., Kunze, S., & Kupka, M. S. (2010) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-8-143 · Cited by 12 · see citing works

Comparative proteome profiling of seminal components reveal impaired immune cell signalling as paternal contributors in recurrent pregnancy loss patients

Jena, S. R., Nayak, J., Kumar, S., Kar, S., & Samanta, L. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13613 · Cited by 11 · see citing works

Peroxisome proliferator-activated receptor γ agonist suppresses human telomerase reverse transcriptase expression and aromatase activity in eutopic endometrial stromal cells from endometriosis

Chang, H. J., Lee, J. H., Hwang, K. J., Kim, J.-H., & Yoo, J. H. (2013) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2013.40.2.67 · Cited by 11 · see citing works

Epithelial and stromal-specific immune pathway activation in the murine endometrium post-coitum

Field, S. L., Cummings, M., & Orsi, N. M. (2015) · Reproduction · doi:10.1530/rep-15-0087 · Cited by 9 · see citing works

Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway

Zhang, H., Wang, Z., Zhou, Q., Cao, Z., Jiang, Y., Xu, M., Liu, J., Zhou, J., Yan, G., & Sun, H. (2023) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-023-02762-7 · Cited by 6 · see citing works

Decidual cell differentiation is evolutionarily derived from fibroblast activationPreprint

Wu, L., Stadtmauer, D. J., Maziarz, J. D., & Wagner, G. P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.18.423527 · Cited by 6 · see citing works

Primary cilia abnormalities participate in the occurrence of spontaneous abortion through TGF‐β/SMAD2/3 signaling pathway

Yu, X., Li, L., Ning, A., Wang, H., Guan, C.-Y., Ma, X., & Xia, H. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31292 · Cited by 5 · see citing works

Cyclooxygenase 2 overexpression suppresses Smad3 and augments ERK1/2 signaling activated by TGFβ1 in endometrial stromal cells: A novel insight into endometriosis pathogenesis

Wang, T., Ji, M., Yang, P., Zhang, J., Peng, X., Miao, Y., Liu, W., & Sun, J. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112470 · Cited by 4 · see citing works

Amino Acid Restriction Impairs Human Endometrial Stromal Cell Decidualization and Is Rescued by Proline Supplementation

Jang, C. E., Iosef, C., Renaud, S. J., & Han, V. K. M. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70821 · Cited by 3 · see citing works

Identification of molecular signaling pathways underlying human endometrial stromal cell differentiation

Kaya, H. (2014) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Vitamin B12 Inhibits Streptozotocin-Induced Islet β-Cell Oxidative Stress and Apoptosis by Activating Peroxisome Proliferator-Activated Receptor-γ Signaling Pathway

Hu, Q., Li, L., Zhai, Z., Wang, Q., & Liao, S. (2021) · Journal of Biomaterials and Tissue Engineering · doi:10.1166/jbt.2021.2778

Transforming Growth Factor-β1에 의해 유도된 인간 자궁내막 기질세포의 탈락막화에서 Extracellular Signal-Regulated Kinase와 Peroxisome Proliferator-Activated Receptorγ 의 역할

장, 혜. (2007) · AJOU Open Repository (Ajou University)

P-409

Lee, J. H., Kim, M. R., Hwang, K. J., Ahn, S.-M., Chang, H. J., & Kim, Y. A. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.07.769

TGF-β1에 의하여 유도된 인간자궁내막의 탈락막화 (Decidualization)에 있어서 ERK (Extracellular Signal Regulated Kinas)와 PPARγ (Peroxisome Proliferator-Activated Receptor Gamma)의 역할

장, 혜., 이, 재., 김, 미., 황, 경., 박, 동., & 민철기 (2006) · AJOU Open Repository (Ajou University)

Effect of Transforming Growth Factor (TGF)-beta and Peroxisome Proliferator-Activated Receptor (PPAR)-gamma in Endometrial Decidualization.

Kwon, J. H., Lee, J. H., Chang, H. J., Park, D. W., Kim, Y. A., Kim, J.-H., & Hwang, K. J. (2006) · Obstetrics & Gynecology Science · Cited by 1 · see citing works

자궁내막 탈락막화에서 Transforming growth factor (TGF)-β와 Peroxisome proliferator-activated receptor (PPAR)-gamma가 미치는 영향

권, 종., 이, 재., 장, 혜., 박, 동., 김, 영., 김, 미., & 황, 경. (2006) · AJOU Open Repository (Ajou University)