RETRACTED: Effect of sperm morphology and number on success of intrauterine insemination
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Objective To assess the effects of the number of motile spermatozoa inseminated and percentage of morphologically normal spermatozoa on the success of IUI. Design A prospective observational study. Setting University teaching hospital and private practice setting. Patient(s) The study comprised 393 couples who underwent 714 IUI cycles. Intervention(s) All IUI cycles were preceded by ovarian superovulation with clomiphene citrate 50 mg tablets orally twice daily for 5 days starting on the second day of menses and one hMG ampule 75 IU IM daily for 5 days starting day 5 of the cycle. Cycles were monitored by transvaginal ultrasound. The IUI was performed with a catheter 36 +/- 4 hours after hCG injection. Main outcome measure(s) Clinical pregnancy. Result(s) A total of 79 clinical pregnancies were obtained, for a pregnancy rate per cycle of 11.06%. The pregnancy rate per cycle was 5.55% when the number of motile spermatozoa was <5 x 10(6) and 24.28% with normal motile sperm >5 x 10(6). For patients <25 years old, with number of motile spermatozoa >5 x 10(6), the pregnancy rate per cycle was 28.2%, which is significantly higher than that of other age groups. Above the age of 35 years, no pregnancies were reported with number of motile spermatozoa <5 x 10(6), and the pregnancy rate was very low (0.84%) with number of motile spermatozoa >5 x 10(6). When the normal sperm morphology was >30% and number of motile spermatozoa inseminated >5 x 10(6), the pregnancy rate was 20.77%. Conclusion(s) Intrauterine insemination used for treating male factor infertility has little chance of success when the woman is older than 35 years, the number of motile spermatozoa inseminated is <5 x 10(6), or normal sperm morphology is <30%.
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Badawy et al. (2009) showed that IUI is less successful when both the total number of inseminated motile spermatozoa is low and postwash morphology is poor.
“Badawy et al. (2009) showed that IUI is less successful when both total number of inseminated motile spermatozoa is low and postwash morphology is poor.”
From Total motile sperm count: a better indicator for the severity of male factor infertility than the WHO sperm classification system (2015) · cites this paper as Badawy et al. (2009)
Studies examining sperm morphology and pregnancy outcomes following IUI and IVF have produced variable results.
“In the context of these aforementioned limitations, studies have been performed examining sperm morphology and pregnancy outcomes following IUI7891011 and IVF112131415161718 with variable results.”
From Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction (2017) · cites this paper as [8]
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Cites
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Hamilton, J. A. M., Cissen, M., Brandes, M., Smeenk, J. M. J., de Bruin, J. P., Kremer, J. A. M., Nelen, W. L. D. M., & Hamilton, C. J. C. M. (2015) · Human Reproduction · doi:10.1093/humrep/dev058 · Cited by 236 · see citing works
Smith, R., Kovac, J., Cajipe, M., Lamb, D., & Lipshultz, L. (2017) · Asian Journal of Andrology · doi:10.4103/1008-682x.189211 · Cited by 66 · see citing works
- Authors
- Badawy, A., Elnashar, A., & Eltotongy, M.
- Affiliations
- Mansoura University (EG)
- Benha University (EG)
- Corresponding author
- Badawy, Ahmed
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 91
- Issue
- 3
- Pages
- 777-781
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2082449316
- Cited by
- 84
- References
- 3
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 12 · 2012: 3
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- intrauterine insemination, sperm morphology, male factor infertility, clinical pregnancy rate, maternal age, clomiphene citrate, hMG, retracted article
- MeSH terms
- Adult, Age Factors, Clomiphene, Female, Fertility Agents, Female, Chorionic Gonadotropin, Humans, Infertility, Male, Insemination, Artificial, Male, Ovulation Induction, Pregnancy, Prospective Studies, Sperm Count, Sperm Motility, Spermatozoa, Treatment Outcome, Pregnancy Rate, Cell Shape, Young Adult
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