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Cited by 193Renin-Angiotensin System StudiesReproductive Biology and FertilityOvarian function and disorders

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary

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Reis, Fernando M., Bouissou, Daniela R., Pereira, Virginia M., Camargos, Aroldo F., dos Reis, Adelina M., Santos, Robson A.·2011·Fertility and Sterility
DOI 10.1016/j.fertnstert.2010.06.060
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Abstract

Objective To investigate whether angiotensin (Ang)-(1-7), its receptor Mas, and angiotensin-converting enzyme type 2 (ACE2) are present in human ovary. Design Cross-sectional study. Setting Academic hospital. Patient(s) Twelve reproductive-age women and five postmenopausal women undergoing oophorectomy for nonovarian diseases and seven women having controlled ovarian hyperstimulation for IVF. Intervention(s) Ovarian tissue was obtained from the reproductive-age women and postmenopausal women undergoing oophorectomy for nonovarian diseases. Follicular fluid (FF) samples were obtained from the women having controlled ovarian hyperstimulation for IVF. Main outcome measure(s) Localization of Ang-(1-7) and Mas by immunohistochemistry; measurement of Ang-(1-7) in ovarian FF by RIA; detection of messenger RNAs encoding Mas and ACE2 with use of real-time polymerase chain reaction; assessment of 125I-labeled Ang-(1-7) binding to ovarian sections with use of autoradiographic binding assay. Result(s) Angiotensin-(1-7) and the receptor Mas were localized to primordial, primary, secondary, and antral follicles, stroma, and corpora lutea of reproductive-age ovaries. Postmenopausal women expressed both the peptide and its receptor in the ovarian stroma. Angiotensin-(1-7) was detectable in FF (mean±SE: 191±54 pg/mL). Both Mas and ACE2 messenger RNAs were expressed in ovarian tissue, as revealed by real-time polymerase chain reaction, and ovarian binding sites for 125I-labeled Ang-(1-7) were identified by autoradiography. Conclusion(s) Angiotensin-(1-7), its receptor Mas, and ACE2 are expressed in the human ovary. The peptide is present in several ovarian compartments and can be quantified in FF.

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Crossref · 10.1016/j.fertnstert.2010.06.060

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Metadata

Authors
Reis, F. M., Bouissou, D. R., Pereira, V. M., Camargos, A. F., dos Reis, A. M., & Santos, R. A.
Affiliations
Universidade Federal de Minas Gerais (BR)
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2011-01
Volume
95
Issue
1
Pages
176-181
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2010.06.060
OpenAlex
W1980157773
Cited by
193
References
33
Citations by year
2026: 3 · 2025: 11 · 2024: 15 · 2023: 26 · 2022: 34 · 2021: 47 · 2020: 31 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 4
FWCI
2.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundação de Amparo à Pesquisa do Estado de Minas Gerais
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
angiotensin-(1-7), Mas receptor, human ovary, follicular fluid, ovarian follicles, corpus luteum, ovarian stroma, postmenopausal women, controlled ovarian stimulation, renin-angiotensin system
MeSH terms
Angiotensin-Converting Enzyme 2, Proto-Oncogene Mas, Adult, Angiotensin I, Angiotensin II, Autoradiography, Female, Fertilization in Vitro, Humans, Immunohistochemistry, Iodine Radioisotopes, Peptidyl-Dipeptidase A, Middle Aged, Ovary, Ovulation Induction, Peptide Fragments, Proto-Oncogene Proteins, RNA, Messenger, Follicular Fluid, Premenopause, Postmenopause, Reverse Transcriptase Polymerase Chain Reaction, Receptors, G-Protein-Coupled

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