The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary
Open accessAbstract
Objective To investigate whether angiotensin (Ang)-(1-7), its receptor Mas, and angiotensin-converting enzyme type 2 (ACE2) are present in human ovary. Design Cross-sectional study. Setting Academic hospital. Patient(s) Twelve reproductive-age women and five postmenopausal women undergoing oophorectomy for nonovarian diseases and seven women having controlled ovarian hyperstimulation for IVF. Intervention(s) Ovarian tissue was obtained from the reproductive-age women and postmenopausal women undergoing oophorectomy for nonovarian diseases. Follicular fluid (FF) samples were obtained from the women having controlled ovarian hyperstimulation for IVF. Main outcome measure(s) Localization of Ang-(1-7) and Mas by immunohistochemistry; measurement of Ang-(1-7) in ovarian FF by RIA; detection of messenger RNAs encoding Mas and ACE2 with use of real-time polymerase chain reaction; assessment of 125I-labeled Ang-(1-7) binding to ovarian sections with use of autoradiographic binding assay. Result(s) Angiotensin-(1-7) and the receptor Mas were localized to primordial, primary, secondary, and antral follicles, stroma, and corpora lutea of reproductive-age ovaries. Postmenopausal women expressed both the peptide and its receptor in the ovarian stroma. Angiotensin-(1-7) was detectable in FF (mean±SE: 191±54 pg/mL). Both Mas and ACE2 messenger RNAs were expressed in ovarian tissue, as revealed by real-time polymerase chain reaction, and ovarian binding sites for 125I-labeled Ang-(1-7) were identified by autoradiography. Conclusion(s) Angiotensin-(1-7), its receptor Mas, and ACE2 are expressed in the human ovary. The peptide is present in several ovarian compartments and can be quantified in FF.
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“In the human ovary, local RAS is involved in many important physiological processes such as supporting oogenesis, regulating ovulation function, synthesizing steroid hormones, and mediating gonadotropin function [7, 23–25].”
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Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
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Self-citationIntercellular Communication in the Mammalian Ovary: Oocytes Carry the Conversation
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Recent advances in the angiotensin‐converting enzyme 2–angiotensin(1–7)–Mas axis
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Self-citationSantos, R. A. S., Campagnole‐Santos, M. J., & Andrade, S. P. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00138-5 · Cited by 382
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Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain
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Self-citationBlockage of Ovulation by an Angiotensin Antagonist
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Self-citationLightman, A., Tarlatzis, B. C., Rzasa, P. J., Culler, M. D., Caride, V. J., Negro-Vilar, A. F., Lennard, D. E., DeCherney, A. H., & Naftolin, F. N. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(87)90336-x · Cited by 120
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Jing, Y., Li, R.-Q., Wang, H., Hao-Ran, C., Liu, Y.-B., Gao, Y., & Chen, F. (2020) · Molecular Human Reproduction · doi:10.1093/molehr/gaaa030 · Cited by 411
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Angiotensin-(1–7): beyond the cardio-renal actions
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Self-citationPotential risks of SARS-CoV-2 infection on reproductive health
Li, R., Yin, T., Fang, F., Li, Q., Chen, J., Wang, Y., Hao, Y., Wu, G., Duan, P., Wang, Y., et al. (2020) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2020.04.018 · Cited by 198
Metadata
- Authors
- Reis, F. M., Bouissou, D. R., Pereira, V. M., Camargos, A. F., dos Reis, A. M., & Santos, R. A.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 95
- Issue
- 1
- Pages
- 176-181
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1980157773
- Cited by
- 193
- References
- 33
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 15 · 2023: 26 · 2022: 34 · 2021: 47 · 2020: 31 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- angiotensin-(1-7), Mas receptor, human ovary, follicular fluid, ovarian follicles, corpus luteum, ovarian stroma, postmenopausal women, controlled ovarian stimulation, renin-angiotensin system
- MeSH terms
- Angiotensin-Converting Enzyme 2, Proto-Oncogene Mas, Adult, Angiotensin I, Angiotensin II, Autoradiography, Female, Fertilization in Vitro, Humans, Immunohistochemistry, Iodine Radioisotopes, Peptidyl-Dipeptidase A, Middle Aged, Ovary, Ovulation Induction, Peptide Fragments, Proto-Oncogene Proteins, RNA, Messenger, Follicular Fluid, Premenopause, Postmenopause, Reverse Transcriptase Polymerase Chain Reaction, Receptors, G-Protein-Coupled
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