The ACE2/angiotensin-(1-7)/MAS Axis of the renin-angiotensin system: focus on angiotensin-(1-7)

Santos, Robson Augusto Souza; Sampaio, Walkyria Oliveira; Alzamora, Andreia C.; Motta-Santos, Daisy; Alenina, Natalia; Bader, Michael; Campagnole-Santos, Maria Jose

doi:10.1152/physrev.00023.2016

Cited by 1,144Renin-Angiotensin System StudiesCoagulation, Bradykinin, Polyphosphates, and AngioedemaEicosanoids and Hypertension Pharmacology

The ACE2/angiotensin-(1-7)/MAS Axis of the renin-angiotensin system: focus on angiotensin-(1-7)

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Santos, Robson Augusto Souza, Sampaio, Walkyria Oliveira, Alzamora, Andreia C., Motta-Santos, Daisy, Alenina, Natalia, Bader, Michael, Campagnole-Santos, Maria Jose·2018·Physiological Reviews

DOI 10.1152/physrev.00023.2016PMC PMC7203574

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Abstract

The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and functions throughout the body. The classical view of this system saw it as a sequence of many enzymatic steps that culminate in the production of a single biologically active metabolite, the octapeptide angiotensin (ANG) II, by the angiotensin converting enzyme (ACE). The past two decades have revealed new functions for some of the intermediate products, beyond their roles as substrates along the classical route. They may be processed in alternative ways by enzymes such as the ACE homolog ACE2. One effect is to establish a second axis through ACE2/ANG-(1-7)/MAS, whose end point is the metabolite ANG-(1-7). ACE2 and other enzymes can form ANG-(1-7) directly or indirectly from either the decapeptide ANG I or from ANG II. In many cases, this second axis appears to counteract or modulate the effects of the classical axis. ANG-(1-7) itself acts on the receptor MAS to influence a range of mechanisms in the heart, kidney, brain, and other tissues. This review highlights the current knowledge about the roles of ANG-(1-7) in physiology and disease, with particular emphasis on the brain.

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SARS-CoV-2 uses ACE2 as its main receptor to infect lung epithelial and endothelial cells.
“SARS-CoV-2 spike protein uses ACE2 as its main receptor, suggesting that the Renin-Angiotensin System (RAS) could play a role in COVID-19 pathology.”
From Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trial (2024) · cites this paper as [11]

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Li, Y., Cao, Y., Zeng, Z., Liang, M., Xue, Y., Xi, C., Zhou, M. S., & Jiang, W. (2015) · Scientific Reports · doi:10.1038/srep08209 · Cited by 104 · see citing works
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Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923 · see citing works
A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M. L., Stagliano, N. E., Donovan, M. J., Woolf, B., Robison, K. E., Jeyaseelan, R., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.5.e1 · Cited by 3,084 · see citing works
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453 · see citing works
A Human Homolog of Angiotensin-converting Enzyme
Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E. H., Christie, G., & Turner, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002615200 · Cited by 2,032 · see citing works
Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas
Santos, R. A. S., Silva, A. C. S. E., Maric, C., Silva, D. M. R., Machado, R. P., de Buhr, I., Heringer‐Walther, S., Pinheiro, S. V. B., Lopes, M. T., Bäder, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432869100 · Cited by 1,805 · see citing works
Self-citation
Angiotensin-converting enzyme 2 is an essential regulator of heart function
Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., et al. (2002) · Nature · doi:10.1038/nature00786 · Cited by 1,733 · see citing works
Functional organization of central pathways regulating the cardiovascular system
Dampney, R. A. L. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.2.323 · Cited by 1,648 · see citing works
Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase
Vickers, C., Hales, P., Kaushik, V. K., Dick, L. R., Gavin, J. M., Tang, J., Godbout, K., Parsons, T. F., Baronas, E., Hsieh, F., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200581200 · Cited by 1,406 · see citing works
Renin-angiotensin system: biochemistry and mechanisms of action.
Peach, M. J. (1977) · Physiological Reviews · doi:10.1152/physrev.1977.57.2.313 · Cited by 1,380 · see citing works
Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2
Netland, J., Meyerholz, D. K., Moore, S., Cassell, M., & Perlman, S. (2008) · Journal of Virology · doi:10.1128/jvi.00737-08 · Cited by 1,293 · see citing works
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271 · see citing works
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
Murphy, T. J., Alexander, R. W., Griendling, K. K., Runge, M. S., & Bernstein, K. E. (1991) · Nature · doi:10.1038/351233a0 · Cited by 1,250 · see citing works
The Molecular Basis of Muscular Dystrophy in the mdx Mouse: a Point Mutation
Sicinski, P., Geng, Y., Ryder-Cook, A. S., Barnard, E. A., Darlison, M. G., & Barnard, P. J. (1989) · Science · doi:10.1126/science.2662404 · Cited by 1,086 · see citing works
Induction of Pancreatic Differentiation by Signals from Blood Vessels
Lammert, E., Cleaver, O. B., & Melton, D. A. (2001) · Science · doi:10.1126/science.1064344 · Cited by 1,048 · see citing works
Lethal Infection of K18- hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus
McCray, P. B., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H. P., Halabi, C., Sigmund, C. D., et al. (2007) · Journal of Virology · doi:10.1128/jvi.02012-06 · Cited by 1,010 · see citing works
Role of the ACE2/angiotensin 1-7 axis of the renin-angiotensin system in heart failure
Patel, V. B., Zhong, J.-C., Grant, M. B., & Oudit, G. Y. (2016) · Circulation Research · doi:10.1161/circresaha.116.307708 · Cited by 833 · see citing works
Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor
Sasaki, K., Yamano, Y., Bardhan, S., et al. (1991) · Nature · doi:10.1038/351230a0 · Cited by 814 · see citing works
Phosphorylation of Thr 495 Regulates Ca 2+ /Calmodulin-Dependent Endothelial Nitric Oxide Synthase Activity
Fleming, I., Fisslthaler, B., Dimmeler, S., Kemp, B. E., & Busse, R. (2001) · Circulation Research · doi:10.1161/hh1101.092677 · Cited by 770 · see citing works
Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)
Lambert, D., Yarski, M., Warner, F. J., Thornhill, P., Parkin, E. T., Smith, A. I., Hooper, N. M., & Turner, A. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505111200 · Cited by 697 · see citing works
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
Rice, G., Thomas, D. A., Grant, P. J., Turner, A. J., & Hooper, N. M. (2004) · Biochemical Journal · doi:10.1042/bj20040634 · Cited by 619 · see citing works
G Protein–Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives
Ferré, S., Casadó, V., Devi, L. A., Filizola, M., Jockers, R., Lohse, M. J., Milligan, G., Pin, J., & Guitart, X. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008052 · Cited by 574 · see citing works
Angiotensin-(1-7) Through Receptor Mas Mediates Endothelial Nitric Oxide Synthase Activation via Akt-Dependent Pathways
Sampaio, W. O., Santos, R. A. S., Faria-Silva, R., Machado, L. T., Schiffrin, E. L., & Touyz, R. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000251865.35728.2f · Cited by 563 · see citing works
Self-citation
Angiotensin I converting enzyme.
Erdös, E. G. (1975) · Circulation Research · doi:10.1161/01.res.36.2.247 · Cited by 557 · see citing works
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains
Young, D., Waitches, G. M., Birchmeier, C., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90785-3 · Cited by 484 · see citing works
Insulin resistance and hypertension
Sowers, J. R. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00026.2004 · Cited by 475 · see citing works
Discovery and Characterization of Alamandine
Lautner, R. Q., Villela, D. C., Fraga-Silva, R. A., Silva, N., Verano‐Braga, T., Costa-Fraga, F. P., Jankowski, J., Jankowski, V., Sousa, F. B. D., Alzamora, A. C., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.301077 · Cited by 440 · see citing works
Self-citation
G-Protein–Coupled Receptor Mas Is a Physiological Antagonist of the Angiotensin II Type 1 Receptor
Kostenis, E., Milligan, G., Christopoulos, A., Sánchez‐Ferrer, C. F., Heringer‐Walther, S., Sexton, P. M., Gembardt, F., Kellett, E., Martini, L., Vanderheyden, P., et al. (2005) · Circulation · doi:10.1161/01.cir.0000160867.23556.7d · Cited by 415 · see citing works
Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system
Doobay, M. F., Talman, L. S., Obr, T. D., Tian, X., Davisson, R. L., & Lazartigues, E. D. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00292.2006 · Cited by 407 · see citing works
Angiotensin-(1-7) Dilates Canine Coronary Arteries Through Kinins and Nitric Oxide
Brosnihan, K. B., Li, P., & Ferrario, C. M. (1996) · Hypertension · doi:10.1161/01.hyp.27.3.523 · Cited by 405 · see citing works
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
Zou, Z., Yan, Y., Shu, Y., Gao, R., Sun, Y., Li, X., Ju, X., Liang, Z., Liu, Q., Zhao, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms4594 · Cited by 401 · see citing works
The mas oncogene encodes an angiotensin receptor
Jackson, T., Blair, L. A. C., Marshall, J., Goedert, M., & Hanley, M. R. (1988) · Nature · doi:10.1038/335437a0 · Cited by 396 · see citing works
Angiotensin-(1–7): an update
Santos, R. A. S., Campagnole‐Santos, M. J., & Andrade, S. P. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00138-5 · Cited by 382 · see citing works
Self-citation
Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects
Haschke, M., Schuster, M., Poglitsch, M., Loibner, H., Salzberg, M. O., Bruggisser, M., Penninger, J. M., & Krähenbühl, S. (2013) · Clinical Pharmacokinetics · doi:10.1007/s40262-013-0072-7 · Cited by 362 · see citing works
Cardiac cachexia: A systematic overview
von Haehling, S., Lainščak, M., Springer, J., & Anker, S. D. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.009 · Cited by 351 · see citing works
Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy
Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W. C., Burrell, L. M., Risvanis, J., & Cooper, M. E. (2003) · Hypertension · doi:10.1161/01.hyp.0000060689.38912.cb · Cited by 349 · see citing works
Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension
Boustany, C., Bharadwaj, K. G., Daugherty, A., Brown, D. R., Randall, D. C., & Cassis, L. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00265.2004 · Cited by 336 · see citing works
Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2
Paizis, G., Tikellis, C., Cooper, M. E., Schembri, J. M., Lew, R. A., Smith, A. I., Shaw, T., Warner, F. J., Zuilli, A., Burrell, L. M., et al. (2005) · Gut · doi:10.1136/gut.2004.062398 · Cited by 334 · see citing works
Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1–7)
Grobe, J. L., Mecca, A. P., Lingis, M., Shenoy, V., Bolton, T. A., Machado, J. M., Speth, R. C., Raizada, M. K., & Katovich, M. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00937.2006 · Cited by 332 · see citing works
Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice
Gurley, S. B., Allred, A. J., Le, T. H., Griffiths, R., Mao, L., Philip, N., Haystead, T., Donoghue, M., Breitbart, R. E., Acton, S. L., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci16980 · Cited by 330 · see citing works
Deletion of Angiotensin-Converting Enzyme 2 Accelerates Pressure Overload-Induced Cardiac Dysfunction by Increasing Local Angiotensin II
Yamamoto, K. I., Ohishi, M., Katsuya, T., Ito, N., Ikushima, M., Kaibe, M., Tatara, Y., Shiota, A., Sugano, S., Takeda, S., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000205833.89478.5b · Cited by 323 · see citing works
Angiotensin-(1–7) inhibits growth of cardiac myocytes through activation of themasreceptor
Tallant, E. A., Ferrario, C. M., & Gallagher, P. E. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00941.2004 · Cited by 317 · see citing works
Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload
Kuba, K., Zhang, L., Imai, Y., Arab, S., Chen, M., Maekawa, Y., Leschnik, M. W., Leibbrandt, A., Markovic, M., Schwaighofer, J., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.158659 · Cited by 309 · see citing works
Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles
Zisman, L. S., Keller, R. S., Weaver, B. A., Lin, Q., Speth, R. C., Bristow, M. R., & Canver, C. C. (2003) · Circulation · doi:10.1161/01.cir.0000094734.67990.99 · Cited by 308 · see citing works
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis
Lovren, F., Pan, Y., Quan, A., Teoh, H., Wang, G., Shukla, P. C., Levitt, K., Oudit, G. Y., Al-Omran, M. A., Stewart, D. J., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00331.2008 · Cited by 307 · see citing works
Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin‐(1–7) or an angiotensin II receptor antagonist
Asperen, R. M. W., Lutter, R., Specht, P. A. C., Moll, G. N., van Woensel, J. B. M., van der Loos, C. M., van Goor, H., Kamilić, J., Florquin, S., & Bos, A. P. (2011) · The Journal of Pathology · doi:10.1002/path.2987 · Cited by 304 · see citing works
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli
Karnik, S. S., Ünal, H., Kemp, J. R., Tirupula, K. C., Eguchi, S., Vanderheyden, P., & Thomas, W. G. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.010454 · Cited by 302 · see citing works
Angiotensin-(1-7) Inhibits Vascular Smooth Muscle Cell Growth
Freeman, E. J., Chisolm, G. M., Ferrario, C. M., et al. (1996) · Hypertension · doi:10.1161/01.hyp.28.1.104 · Cited by 296 · see citing works
Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide.
Schiavone, M. T., Santos, R. A. S., Brosnihan, K. B., et al. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4095 · Cited by 288 · see citing works
Self-citation
Metabolism of Angiotensin-(1–7) by Angiotensin-Converting Enzyme
Chappell, M. C., Pirro, N. T., Sykes, A., & Ferrario, C. M. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.362 · Cited by 288 · see citing works
Characterization of a new angiotensin antagonist selective for angiotensin-(1–7): Evidence that the actions of angiotensin-(1–7) are mediated by specific angiotensin receptors
Santos, R. A. S., Campagnole‐Santos, M. J., Baracho, N. C. V., et al. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90104-x · Cited by 287 · see citing works
Self-citation
FOXO transcription factors in cancer development and therapy
de Brachène, A. C., & Demoulin, J. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2112-y · Cited by 285 · see citing works
Angiotensin-(1-7) Counterregulates Angiotensin II Signaling in Human Endothelial Cells
Sampaio, W. O., Castro, C. H., Santos, R. A. S., Schiffrin, E. L., & Touyz, R. M. (2007) · Hypertension · doi:10.1161/hypertensionaha.106.084848 · Cited by 283 · see citing works
Self-citation
The Angiotensin-Converting Enzyme 2/Angiogenesis-(1–7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension
Shenoy, V., Ferreira, A. J., Qi, Y., Fraga-Silva, R. A., Díez-Freire, C., Dooies, A., Jun, J. Y., Sriramula, S., Mariappan, N., Pourang, D., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1840oc · Cited by 282 · see citing works
Self-citation
Structure-Based Identification of Small-Molecule Angiotensin-Converting Enzyme 2 Activators as Novel Antihypertensive Agents
Prada, J. A. H., Ferreira, A. J., Katovich, M. J., Shenoy, V., Qi, Y., Santos, R. A. S., Castellano, R. K., Lampkins, A. J., Gubala, V., Ostrov, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.108944 · Cited by 273 · see citing works
Self-citation
Loss of Angiotensin-Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury
Wong, D., Oudit, G. Y., Reich, H. N., Kassiri, Z., Zhou, J., Liu, Q. C., Backx, P. H., Penninger, J. M., Herzenberg, A. M., & Scholey, J. W. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060977 · Cited by 267 · see citing works
Angiotensin-(1–7)
Santos, R. A. S. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.01274 · Cited by 260 · see citing works
Self-citation
ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity
Patel, V. B., Mori, J., McLean, B. A., Basu, R., Das, S. K., Ramprasath, T., Parajuli, N., Penninger, J. M., Grant, M. B., Lopaschuk, G. D., et al. (2015) · Diabetes · doi:10.2337/db15-0399 · Cited by 257 · see citing works
Distribution of Angiotensin-(1-7) and ACE2 in Human Placentas of Normal and Pathological Pregnancies
Valdés, G., Neves, L. A. A., Anton, L., Corthorn, J. L., Chacón, C., Germaín, A., Merrill, D., Ferrario, C. M., Sarao, R., Penninger, J. M., et al. (2005) · Placenta · doi:10.1016/j.placenta.2005.02.015 · Cited by 256 · see citing works
Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.
Yang, X. H., Deng, W., Tong, Z., Liu, Y., Zhang, L. F., Zhu, H., Gao, H., Huang, L., Liu, Y. I., Ma, C. M., et al. (2007) · PubMed · Cited by 252 · see citing works
The CNS renin-angiotensin system
Halbach, O. V. B. U., & Albrecht, D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0190-8 · Cited by 251 · see citing works
ACE inhibition, ACE2 and angiotensin-(17) axis in kidney and cardiac inflammation and fibrosis
Silva, A. C. S. E., & Teixeira, M. M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.018 · Cited by 248 · see citing works
Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension
Ferreira, A. J., Shenoy, V., Yamazato, Y., Sriramula, S., Francis, J., Yuan, L., Castellano, R. K., Ostrov, D. A., Oh, S. P., Katovich, M. J., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200811-1678oc · Cited by 245 · see citing works
Severe Acute Respiratory Syndrome Coronavirus Infection of Mice Transgenic for the Human Angiotensin-Converting Enzyme 2 Virus Receptor
Tseng, C.-T. K., Huang, C., Newman, P. C., Wang, N., Narayanan, K., Watts, D. M., Makino, S., Packard, M. M., Zaki, S. R., Chan, T., et al. (2006) · Journal of Virology · doi:10.1128/jvi.01702-06 · Cited by 244 · see citing works
Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism
Santos, S. H. S., Fernandes, L. R., Mário, É. G., Ferreira, A. V. M., Pôrto, L. C. J., Alvarez-Leite, J. I., Botion, L. M., Bäder, M., Alenina, N. V., & Santos, R. A. S. (2007) · Diabetes · doi:10.2337/db07-0953 · Cited by 241 · see citing works
Self-citation
Angiotensin-(1-7): Cardioprotective Effect in Myocardial Ischemia/Reperfusion
Ferreira, A. J., Santos, R. A. S., & Almeida, A. P. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.665 · Cited by 240 · see citing works
Self-citation
Release of nitric oxide by angiotensin‐(1–7) from porcine coronary endothelium: implications for a novel angiotensin receptor
Pörsti, I. H., Bara, A. T., Busse, R., et al. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14787.x · Cited by 239 · see citing works
Impairment of In Vitro and In Vivo Heart Function in Angiotensin-(1-7) Receptor Mas Knockout Mice
Santos, R. A. S., Castro, C. H., Gava, E., Pinheiro, S. V. B., Almeida, A. P., de Paula, R. D., Cruz, J. S., Ramos, A. S., Rosa, K. T., Irigoyen, M. C., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000215289.51180.5c · Cited by 237 · see citing works
Self-citation
Brain renin-angiotensin—A new look at an old system
Wright, J. W., & Harding, J. W. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.07.001 · Cited by 233 · see citing works
Angiotensin-(1–7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects
Iwata, M., Cowling, R. T., Gurantz, D., Moore, C., Zhang, S., Yuan, J. X.-J., & Greenberg, B. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00317.2005 · Cited by 231 · see citing works
The intrarenal renin–angiotensin system and diabetic nephropathy
Carey, R. M., & Siragy, H. M. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00111-5 · Cited by 230 · see citing works
Genetic Ace2 Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the ApoE Knockout Mouse
Thomas, M. C., Pickering, R. J., Tsorotes, D., Koı̈tka, A., Sheehy, K., Bernardi, S., Toffoli, B., Nguyen‐Huu, T., Head, G. A., Fu, Y., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.219279 · Cited by 230 · see citing works
Regulation of ACE2 in cardiac myocytes and fibroblasts
Gallagher, P. E., Ferrario, C. M., & Tallant, E. A. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00426.2008 · Cited by 229 · see citing works
Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart
Mercure, C., Yogi, Á., Callera, G. E., Aranha, A. B., Bäder, M., Ferreira, A. J., Santos, R. A. S., Walther, T., Touyz, R. M., & Reudelhuber, T. L. (2008) · Circulation Research · doi:10.1161/circresaha.108.184911 · Cited by 226 · see citing works
Self-citation
Loss of Angiotensin-Converting Enzyme 2 Accelerates Maladaptive Left Ventricular Remodeling in Response to Myocardial Infarction
Kassiri, Z., Zhong, J., Guo, D., Basu, R., Wang, X., Liu, P. P., Scholey, J. W., Penninger, J. M., & Oudit, G. Y. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.840124 · Cited by 226 · see citing works
Antihypertensive actions of angiotensin-(1-7) in spontaneously hypertensive rats
Benter, I. F., Ferrario, C. M., Morris, M., et al. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.1.h313 · Cited by 225 · see citing works
Angiotensin-(1-7) in Normal and Preeclamptic Pregnancy
Merrill, D., Karoly, M., Chen, K., et al. (2002) · Endocrine · doi:10.1385/endo:18:3:239 · Cited by 224 · see citing works
Vasodilator Action of Angiotensin-(1-7) on Isolated Rabbit Afferent Arterioles
Ren, Y., Garvin, J. L., & Carretero, O. A. (2002) · Hypertension · doi:10.1161/hy0302.104673 · Cited by 223 · see citing works
A protein complex in the brush‐border membrane explains a Hartnup disorder allele
Kowalczuk, S., Bröer, A., Tietze, N., Vanslambrouck, J. M., Rasko, J. E. J., & Bröer, S. (2008) · The FASEB Journal · doi:10.1096/fj.08-107300 · Cited by 222 · see citing works
Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension
Grobe, J. L., Mecca, A. P., Mao, H., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01170.2005 · Cited by 221 · see citing works
Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins
Donoghue, M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00177-9 · Cited by 214 · see citing works
Identification of angiotensin-(1-7) in rat brain
Chappell, M. C., Brosnihan, K. B., Diz, D. I., & Ferrario, C. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84737-3 · Cited by 213 · see citing works
Angiotensin‐Converting Enzyme Genotype Affects the Response of Human Skeletal Muscle to Functional Overload
Folland, J., Leach, B., Little, T., Hawker, K., Myerson, S., Montgomery, H., & Jones, D. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.02057.x · Cited by 208 · see citing works
Angiotensin-(1–7) Acts as a Vasodepressor Agent Via Angiotensin II Type 2 Receptors in Conscious Rats
Walters, P. E., Gaspari, T. A., & Widdop, R. E. (2005) · Hypertension · doi:10.1161/01.hyp.0000160325.59323.b8 · Cited by 206 · see citing works
Angiotensin-(1–7) Prevents Activation of NADPH Oxidase and Renal Vascular Dysfunction in Diabetic Hypertensive Rats
Benter, I. F., Yousif, M. H. M., Dhaunsi, G. S., Kaur, J., Chappell, M. C., & Diz, D. I. (2007) · American Journal of Nephrology · doi:10.1159/000108758 · Cited by 204 · see citing works
Metabolism of vasoactive peptides by human endothelial cells in culture. Angiotensin I converting enzyme (kininase II) and angiotensinase.
Johnson, A. R., & Erdös, E. G. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108687 · Cited by 202 · see citing works
AVE 0991, a Nonpeptide Mimic of the Effects of Angiotensin-(1–7) on the Endothelium
Wiemer, G., Dobrucki, L. W., Louka, F. R., Maliñski, T., & Heitsch, H. (2002) · Hypertension · doi:10.1161/01.hyp.0000037979.53963.8f · Cited by 199 · see citing works
Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke
Mecca, A. P., Regenhardt, R. W., O’Connor, T. E., Joseph, J. P., Raizada, M. K., Katovich, M. J., & Sumners, C. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2011.058578 · Cited by 197 · see citing works
Update on the Angiotensin Converting Enzyme 2-Angiotensin (1–7)-Mas Receptor Axis: Fetal Programing, Sex Differences, and Intracellular Pathways
Chappell, M. C., Marshall, A. C., Alzayadneh, E. M., Shaltout, H. A., & Diz, D. I. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00201 · Cited by 197 · see citing works
Mass-Spectrometric Identification of a Novel Angiotensin Peptide in Human Plasma
Jankowski, V., Vanholder, R. C., van der Giet, M., Tölle, M., Karadogan, S., Gobom, J., Furkert, J., Oksche, A., Krause, E., Tran, T. N. A., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000253889.09765.5f · Cited by 197 · see citing works
Sustained Long Term Potentiation and Anxiety in Mice Lacking theMas Protooncogene
Walther, T., Balschun, D., Voigt, J., Fink, H., Zuschratter, W., Birchmeier, C., Ganten, D., & Bäder, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11867 · Cited by 196 · see citing works
Angiotensin-(1–7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells
Su, Z., Zimpelmann, J., & Burns, K. D. (2006) · Kidney International · doi:10.1038/sj.ki.5001509 · Cited by 196 · see citing works
Angiotensin Converting Enzyme 2 Contributes to Sex Differences in the Development of Obesity Hypertension in C57BL/6 Mice
Gupte, M., Thatcher, S. E., Boustany, C., Shoemaker, R., Yiannikouris, F. B., Zhang, X., Karounos, M., & Cassis, L. A. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.248559 · Cited by 195 · see citing works
Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary
Reis, F. M., Bouissou, D. R., Pereira, V. M., Camargos, A. F., dos Reis, A. M., & Santos, R. A. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.06.060 · Cited by 193 · see citing works
Self-citation
Systemic and regional hemodynamic effects of angiotensin-(1–7) in rats
Sampaio, W. O., Nascimento, A. A. S., & Santos, R. A. S. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01145.2002 · Cited by 191 · see citing works
Self-citation
Endothelial Dysfunction and Elevated Blood Pressure in Mas Gene-Deleted Mice
Xu, P., Gonçalves, A. C. D. C., Todiraş, M., Rabelo, L. A., Sampaio, W. O., de Moura, M. M., Santos, S. H. S., Luft, F. C., Bäder, M., Groß, V., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.102764 · Cited by 191 · see citing works
Self-citation
Angiotensin-(1–7) Is a Modulator of the Human Renin-Angiotensin System
Roks, A. J. M., van Geel, P. P., Pinto, Y. M., Buikema, H., Henning, R. H., de Zeeuw, D., & van Gilst, W. H. (1999) · Hypertension · doi:10.1161/01.hyp.34.2.296 · Cited by 190 · see citing works
Angiotensin 1–7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation
Mori, J., Patel, V. B., Alrob, O. A., Basu, R., Altamimi, T., DesAulniers, J., Wagg, C. S., Kassiri, Z., Lopaschuk, G. D., & Oudit, G. Y. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000672 · Cited by 190 · see citing works
Brain-Selective Overexpression of Human Angiotensin-Converting Enzyme Type 2 Attenuates Neurogenic Hypertension
Feng, Y., Xia, H., Cai, Y., Halabi, C. M., Becker, L. K., Santos, R. A. S., Speth, R. C., Sigmund, C. D., & Lazartigues, E. D. (2009) · Circulation Research · doi:10.1161/circresaha.109.208645 · Cited by 190 · see citing works
Self-citation
Angiotensin-(1–7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with l -NAME
Benter, I. F., Yousif, M. H. M., Anim, J. T., Cojocel, C., & Diz, D. I. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00632.2005 · Cited by 187 · see citing works
Transgenic Angiotensin-Converting Enzyme 2 Overexpression in Vessels of SHRSP Rats Reduces Blood Pressure and Improves Endothelial Function
Rentzsch, B., Todiraş, M., Iliescu, R., Popova, E., Campos, L. A., Oliveira, M. L., Baltatu, O. C., Santos, R. A. S., & Bäder, M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114322 · Cited by 187 · see citing works
Self-citation
Expression of an angiotensin-(1–7)-producing fusion protein produces cardioprotective effects in rats
Santos, R. A. S., Ferreira, A. J., Nadu, A. P., Braga, A. N. G., Almeida, A. P., Campagnole‐Santos, M. J., Baltatu, O. C., Iliescu, R., Reudelhuber, T. L., & Bäder, M. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00227.2003 · Cited by 187 · see citing works
Self-citation
Converting enzyme activity and angiotensin metabolism in the dog brainstem.
Santos, R. A. S., Brosnihan, K. B., Chappell, M. C., Pesquero, J. L., Chernicky, C. L., Greene, L. J., & Ferrario, C. M. (1988) · Hypertension · doi:10.1161/01.hyp.11.2_pt_2.i153 · Cited by 185 · see citing works
Self-citation
Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas Axis Protects against Lung Fibrosis by Inhibiting the MAPK/NF-κB Pathway
Meng, Y., Yu, C., Li, W., Li, T., Luo, W., Huang, S., Wu, P., Cai, S., & Li, X. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0451oc · Cited by 182 · see citing works
Anti-Inflammatory Effects of the Activation of the Angiotensin-(1–7) Receptor, Mas, in Experimental Models of Arthritis
da Silveira, K. D., Coelho, F. M., Vieira, A. T., Sachs, D., Barroso, L. C., Costa, V. V., Bretas, T. L. B., Bäder, M., Sousa, L. P., Silva, T. A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000314 · Cited by 182 · see citing works
Self-citation
Angiotensin-(1-7): a new hormone of the angiotensin system.
Ferrario, C. M., Brosnihan, K. B., Diz, D. I., Jaiswal, N., Khosla, M. C., Milsted, A., & Tallant, E. A. (1991) · Hypertension · doi:10.1161/01.hyp.18.5_suppl.iii126 · Cited by 182 · see citing works
Overexpression of Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Causes Long-Term Decrease in Blood Pressure in the Spontaneously Hypertensive Rats
Yamazato, M., Yamazato, Y., Sun, C., Díez-Freire, C., & Raizada, M. K. (2007) · Hypertension · doi:10.1161/01.hyp.0000259942.38108.20 · Cited by 180 · see citing works
Skeletal muscle RAS and exercise performance
Jones, A., & Woods, D. R. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00342-4 · Cited by 176 · see citing works
An Intracellular Renin-Angiotensin System in Neurons: Fact, Hypothesis, or Fantasy
Grobe, J. L., Xu, D., & Sigmund, C. D. (2008) · Physiology · doi:10.1152/physiol.00002.2008 · Cited by 176 · see citing works
Signal Transduction Mechanisms Involved in Angiotensin-(1–7)-Stimulated Arachidonic Acid Release and Prostanoid Synthesis in Rabbit Aortic Smooth Muscle Cells
Muthalif, M. M., Benter, I. F., Uddin, M. R., Harper, J. L., & Malik, K. U. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37208-8 · Cited by 175 · see citing works
Nonpeptide AVE 0991 Is an Angiotensin-(1–7) Receptor Mas Agonist in the Mouse Kidney
Pinheiro, S. V. B., Silva, A. C. S. E., Sampaio, W. O., de Paula, R. D., Mendes, E. P., Bontempo, E. D., Pesquero, J. B., Walther, T., Alenina, N. V., Bäder, M., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000141438.64887.42 · Cited by 175 · see citing works
Self-citation
Cardiovascular effects of angiotensin-(1-7) injected into the dorsal medulla of rats
Campagnole‐Santos, M. J., Diz, D. I., Santos, R. A. S., et al. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.257.1.h324 · Cited by 171 · see citing works
Self-citation
Chronic infusion of angiotensin-(1–7) improves insulin resistance and hypertension induced by a high-fructose diet in rats
Giani, J. F., Mayer, M. A., Muñoz, M. C., Silberman, E. A., Höcht, C., Taira, C. A., Gironacci, M. M., Turyn, D., & Dominici, F. P. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90678.2008 · Cited by 170 · see citing works
Renal actions of angiotensin-(1-7): in vivo and in vitro studies
Handa, R. K., Ferrario, C. M., & Strandhoy, J. W. (1996) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1996.270.1.f141 · Cited by 169 · see citing works
Evidence for a Functional Interaction of the Angiotensin-(1–7) Receptor Mas With AT 1 and AT 2 Receptors in the Mouse Heart
Castro, C. H., Santos, R. A. S., Ferreira, A. J., Bäder, M., Alenina, N. V., & Almeida, A. P. (2005) · Hypertension · doi:10.1161/01.hyp.0000175813.04375.8a · Cited by 168 · see citing works
Self-citation
Angiotensin-(1–7) prevents diabetes-induced cardiovascular dysfunction
Benter, I. F., Yousif, M. H. M., Cojocel, C., Al‐Maghrebi, M., & Diz, D. I. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00372.2006 · Cited by 167 · see citing works
Molecular Mechanisms of Inhibition of Vascular Growth by Angiotensin-(1-7)
Tallant, E. A., & Clark, M. A. (2003) · Hypertension · doi:10.1161/01.hyp.0000090322.55782.30 · Cited by 167 · see citing works
Inhibition of human lung cancer cell growth by angiotensin-(1-7)
Gallagher, P. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh236 · Cited by 165 · see citing works
Renin‐Angiotensin System: An Old Player with Novel Functions in Skeletal Muscle
Cabello‐Verrugio, C., Morales, M. G., Rivera, J. C. A., Cabrera, D., & Simón, F. (2015) · Medicinal Research Reviews · doi:10.1002/med.21343 · Cited by 164 · see citing works
Molecular Mechanisms Involved in the Angiotensin-(1-7)/Mas Signaling Pathway in Cardiomyocytes
Dias‐Peixoto, M. F., Santos, R. A. S., Gomes, E. R. D. M., Alves, M. N. M., Almeida, P., Greco, L., Rosa, M. F.-M., Fauler, B., Bäder, M., Alenina, N. V., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114280 · Cited by 163 · see citing works
Self-citation
Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR
Agarwal, D., Welsch, M. A., Keller, J. N., & Francis, J. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0231-7 · Cited by 162 · see citing works
Improved Lipid and Glucose Metabolism in Transgenic Rats With Increased Circulating Angiotensin-(1-7)
Santos, S. H. S., Braga, J. F., Mário, É. G., Pôrto, L. C. J., Rodrigues‐Machado, M. D. G., Murari, A., Botion, L. M., Alenina, N. V., Bäder, M., & Santos, R. A. S. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.200493 · Cited by 162 · see citing works
Self-citation
Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling
Acuña, M. J., Pessina, P., Olguín, H. C., Cabrera, D., Vio, C. P., Bäder, M., Muñoz‐Cánoves, P., Santos, R. A. S., Cabello‐Verrugio, C., & Brandan, E. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt514 · Cited by 159 · see citing works
Self-citation
The Angiotensin-Converting Enzyme 2/Angiotensin (1–7)/Mas Axis Protects Against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-Derived ROS-Mediated RhoA/Rho Kinase Pathway
Meng, Y., Li, T., Zhou, G.-S., Chen, Y., Yu, C., Pang, M.-X., Li, W., Li, Y., Zhang, W., & Li, X. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5818 · Cited by 157 · see citing works
Genetic deletion of the angiotensin-(1–7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria
Pinheiro, S. V. B., Ferreira, A. J., Kitten, G. T., et al. (2009) · Kidney International · doi:10.1038/ki.2009.61 · Cited by 156 · see citing works
Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain
Becker, L. K., Etelvino, G. M., Walther, T., Santos, R. A. S., & Campagnole‐Santos, M. J. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00141.2007 · Cited by 155 · see citing works
Self-citation
Differential baroreceptor reflex modulation by centrally infused angiotensin peptides
Campagnole‐Santos, M. J., Heringer, S. B., Batista, E., et al. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.1.r89 · Cited by 155 · see citing works
Self-citation
Angiotensin‐(1–7) inhibits allergic inflammation, via the MAS1 receptor, through suppression of ERK1/2‐ and NF‐κB‐dependent pathways
El‐Hashim, A. Z., Renno, W. M., Raghupathy, R., Abduo, H., Akhtar, S., & Benter, I. F. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01905.x · Cited by 154 · see citing works
Natriuretic action of angiotensin(1–7)
DelliPizzi, A., Hilchey, S. D., & Bell‐Quilley, C. P. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14014.x · Cited by 152 · see citing works
Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats
Senanayake, P. D., Moriguchi, A., Kumagai, H., Ganten, D., Ferrario, C. M., & Brosnihan, K. B. (1994) · Peptides · doi:10.1016/0196-9781(94)90051-5 · Cited by 151 · see citing works
Production of angiotensin-(1-7) by human vascular endothelium.
Santos, R. A. S., Brosnihan, K. B., Jacobsen, D. W., DiCorleto, P. E., & Ferrario, C. M. (1992) · Hypertension · doi:10.1161/01.hyp.19.2_suppl.ii56 · Cited by 151 · see citing works
Self-citation
Evidence that angiotensin-(1–7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors
Fontes, M. A. P., Silva, L. C. S., Campagnole‐Santos, M. J., et al. (1994) · Brain Research · doi:10.1016/0006-8993(94)91171-1 · Cited by 150 · see citing works
Self-citation
Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog
Kluskens, L., Nelemans, S. A., Rink, R., de Vries, L., Meter-Arkema, A. H., Wang, Y., Walther, T., Kuipers, A., Moll, G. N., & Haas, M. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.146431 · Cited by 150 · see citing works
Medullary gamma-aminobutyric acid (GABA) receptors and the regulation of blood pressure in the rat.
Willette, R. N., Krieger, A. J., Barcas, P. P., et al. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21872-9 · Cited by 149 · see citing works
Suppressing inflammation by inhibiting the NF‐κB pathway contributes to the neuroprotective effect of angiotensin‐(1‐7) in rats with permanent cerebral ischaemia
Jiang, T., Gao, L., Guo, J., Lu, J., Wang, Y., & Zhang, Y. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02105.x · Cited by 148 · see citing works
Differential responses to angiotensin-(1–7) in the feline mesenteric and hindquarters vascular beds
Osei, S. Y., Ahima, R. S., Minkes, R. K., et al. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90703-k · Cited by 147 · see citing works
The Antithrombotic Effect of Angiotensin-(1-7) Involves Mas-Mediated NO Release from Platelets
Fraga-Silva, R. A., Pinheiro, S. V. B., Gonçalves, A. C. D. C., Alenina, N. V., Bäder, M., & Santos, R. A. S. (2008) · Molecular Medicine · doi:10.2119/2007-00073.fraga-silva · Cited by 146 · see citing works
Self-citation
Liver disease and the renin–angiotensin system: Recent discoveries and clinical implications
Lubel, J., Herath, C. B., Burrell, L. M., et al. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05461.x · Cited by 146 · see citing works
An Oral Formulation of Angiotensin-(1-7) Produces Cardioprotective Effects in Infarcted and Isoproterenol-Treated Rats
Marques, F. D., Ferreira, A. J., Sinisterra, R. D., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.167346 · Cited by 145 · see citing works
Angiotensin II directly induces muscle protein catabolism through the ubiquitin–proteasome proteolytic pathway and may play a role in cancer cachexia
Sanders, P. M., Russell, S. T., & Tisdale, M. J. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602725 · Cited by 143 · see citing works
Expression of the mouse and rat mas proto‐oncogene in the brain and peripheral tissues
Metzger, R., Bäder, M., Ludwig, T., Berberich, C. E., Bunnemann, B., & Ganten, D. (1995) · FEBS Letters · doi:10.1016/0014-5793(94)01292-9 · Cited by 143 · see citing works
Angiotensin-(1–7) and angiotensin-(1–9): function in cardiac and vascular remodelling
McKinney, C. A., Fattah, C., Loughrey, C. M., Milligan, G., & Nicklin, S. A. (2014) · Clinical Science · doi:10.1042/cs20130436 · Cited by 142 · see citing works
Oral Delivery of Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7) Bioencapsulated in Plant Cells Attenuates Pulmonary Hypertension
Shenoy, V., Kwon, K., Rathinasabapathy, A., Lin, S., Jin, G., Song, C., Shil, P. K., Nair, A. R., Qi, Y., Li, Q., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03871 · Cited by 142 · see citing works
Angiotensin-(1–7) and the G Protein-Coupled Receptor Mas Are Key Players in Renal Inflammation
Esteban, V., Heringer‐Walther, S., Sterner‐Kock, A., de Bruin, R., van den Engel, S., Wang, Y., Mezzano, S. A., Egido, J., Schultheiss, H., Ruiz‐Ortega, M., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005406 · Cited by 141 · see citing works
Angiotensin-(1-7) Inhibits Growth of Human Lung Adenocarcinoma Xenografts in Nude Mice through a Reduction in Cyclooxygenase-2
Menon, J., Soto‐Pantoja, D. R., Callahan, M. F., Cline, J. M., Ferrario, C. M., Tallant, E. A., & Gallagher, P. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3614 · Cited by 138 · see citing works
Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)
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Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice
Davisson, R. L., Ding, Y., Stec, D. E., et al. (1999) · Physiological Genomics · doi:10.1152/physiolgenomics.1999.1.1.3 · Cited by 133 · see citing works
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Zucker, I. H., Xiao, L., & Haack, K. (2014) · Clinical Science · doi:10.1042/cs20130294 · Cited by 132 · see citing works
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Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice #
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The intracellular renin–angiotensin system: a new paradigm
Kumar, R., Singh, V., & Baker, K. M. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.05.001 · Cited by 131 · see citing works
Angiotensin-(1–7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas
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Angiotensin 1–7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity
Mori, J., Patel, V. B., Ramprasath, T., Alrob, O. A., DesAulniers, J., Scholey, J. W., Lopaschuk, G. D., & Oudit, G. Y. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00655.2013 · Cited by 130 · see citing works
Vascular Relaxation, Antihypertensive Effect, and Cardioprotection of a Novel Peptide Agonist of the Mas Receptor
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Oral Angiotensin-(1–7) prevented obesity and hepatic inflammation by inhibition of resistin/TLR4/MAPK/NF-κB in rats fed with high-fat diet
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Self-citation
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Impact of ACE2 Deficiency and Oxidative Stress on Cerebrovascular Function With Aging
Silva, R. A. P., Chu, Y., Miller, J. D., Mitchell, I. J., Penninger, J. M., Faraci, F. M., & Heistad, D. D. (2012) · Stroke · doi:10.1161/strokeaha.112.667063 · Cited by 120 · see citing works
Angiotensin-(1–7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors
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New Enzymatic Route for the Inactivation of Angiotensin
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Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice
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Angiotensin-(1–7) Protects From Experimental Acute Lung Injury
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Angiotensin-(1-7) and Its Effects in the Kidney
Dilauro, M., & Burns, K. D. (2009) · The Scientific World JOURNAL · doi:10.1100/tsw.2009.70 · Cited by 115 · see citing works
Angiotensin 1-7 has a biphasic effect on fluid absorption in the proximal straight tubule.
Garcia, N. H., & Garvin, J. L. (1994) · Journal of the American Society of Nephrology · doi:10.1681/asn.v541133 · Cited by 115 · see citing works
Angiotensin-(1-7) Formation in the Intact Human Heart
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Role of angiotensin‐converting enzyme 2 and angiotensin(1–7) in 17β‐oestradiol regulation of renal pathology in renal wrap hypertension in rats
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Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury
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Glia- and Neuron-specific Expression of the Renin-Angiotensin System in Brain Alters Blood Pressure, Water Intake, and Salt Preference
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Evidence for an intrinsic angiotensin system in the canine pancreas
Chappell, M. C., Millsted, A., Diz, D. I., Brosnihan, K. B., & Ferrario, C. M. (1991) · Journal of Hypertension · doi:10.1097/00004872-199108000-00008 · Cited by 110 · see citing works
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Angiotensin II- and Angiotensin III-Induced Aldosterone Release in vivo in the Rat
Campbell, W. B., Brooks, S. N., & Pettinger, W. A. (1974) · Science · doi:10.1126/science.184.4140.994 · Cited by 109 · see citing works
The renin–angiotensin system in a rat model of hepatic fibrosis: Evidence for a protective role of Angiotensin-(1–7)
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Self-citation
Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice
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Self-citation
Alamandine
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An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect
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Self-citation
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Welches, W. R., Santos, R. A. S., Chappell, M. C., Brosnihan, K. B., Greene, L. J., & Ferrario, C. M. (1991) · Journal of Hypertension · doi:10.1097/00004872-199107000-00008 · Cited by 105 · see citing works
Self-citation
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Wang, L. A., de Kloet, A. D., Pati, D., Hiller, H., Smith, J. A., Pioquinto, D. J., Ludin, J. A., Oh, S. P., Katovich, M. J., Frazier, C. J., et al. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.026 · Cited by 105 · see citing works
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Tao, L., Qiu, Y., Fu, X., Lin, R., Lei, C., Wang, J., & Lei, B. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0489-7 · Cited by 105 · see citing works
Cardioprotective Effects Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin 1-7 in Experimental Heart Failure in Angiotensin-Converting Enzyme 2–Null Mice
Patel, V. B., Bodiga, S., Dong, F., Das, S. K., Wang, Z., Wang, W., Basu, R., Zhong, J., Kassiri, Z., & Oudit, G. Y. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.191650 · Cited by 104 · see citing works
Regulation of Endothelial Nitric Oxide Synthase Activity and Gene Expression
Wu, K. K. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04062.x · Cited by 103 · see citing works
Angiotensin-(1–7) Improves Liver Fibrosis by Regulating the NLRP3 Inflammasome via Redox Balance Modulation
Cai, S., Yang, R., Li, Y., Ning, Z., Zhang, L., Zhou, G.-S., Luo, W., Li, D.-H., Chen, Y., Pan, M., et al. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6498 · Cited by 103 · see citing works
Angiotensin 1–7 Induces Bradykinin-Mediated Relaxation in Porcine Coronary Artery
Gorelik, G. J., Carbini, L. A., & Scicli, A. G. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37600-1 · Cited by 102 · see citing works

Flagged first, then by citations

Research works printed but not linked: 9

[12]Alzamora A, Santos R, Campagnole-Santos M. Effect of Angiotensin-(1–7) and Angiotensin II microinjection into the caudal ventrolateral medulla on the baroreflex control of heart rate. J Hypertens 16: S181, 1998. [Google Scholar]
[29]Becker L, Santos R, Campagnole-Santos M. The angiotensin-(1–7) receptor Mas is present in cardiovascular-related areas of the rat brain. Hypertension 46: 873, 2005. [Google Scholar]
[74]Carlsson PO. The renin-angiotensin system in the endocrine pancreas. JOP 2: 26–32, 2001. [PubMed] [Google Scholar]
[155]Fernandes L, Fortes Z, Nigro D, Scivoletto R, Santos R, Carvalho M. Interaction of angiotensin-(1–7) and bradykinin in mesenteric microvessels of SHR, studied in vivo-in situ. Hypertension 37: 1007, 2001. [Google Scholar]
[255]Hood K, Yusuf H, Findlay J, Santos R, Castro C, Baillie G, Montezano A, MacLean M, Touyz R. Angiotensin 1–7 Regulation Of Endothelin-1 System In Pulmonary Arterial Hypertension. Hypertension 64: A316, 2014. [Google Scholar]
[265]Jesus I, Scalzo S, Rocha-Resende C, Santos R, Guatimosim S. Alamandine Signaling in Cardiomyocytes in Health and Disease. Hypertension 66: AP140, 2015. [Google Scholar]
[315]Lima D, Fontes M, Campagnole-Santos M, Khosla M, Santos R. Effect of selective angiotensin receptor antagonists on the pressor effect of Angiotensin-I microinjection into the ventrolateral medulla. Hypertension 25: 1410, 1995. [Google Scholar]
[440]Reudelhuber T, Mercure C, Jain D, Bader M, Santos R. Targeted over-production of angiotensin 1–7 in the heart reverses hypertension-related cardiac hypertrophy. Circulation 112: U306, 2005. [Google Scholar]
[540]Tigerstedt R, Bergman PG. Niere und Kreislauf. Acta Physiol (Oxf) 8: 223–271, 1898. [Google Scholar]

Sorted by citations

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“[28,42] ACE2 receptors are also expressed in the adipose tissue [43,44] and a reduction of ACE2 has been noted in the adipose tissue of obese animals [44] In animal experiments, diets rich of fats decreased ACE2 activity and angiotensin1-7, and increased angiotensin II and blood pressure levels in male, but not in fem…”
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“The loss of the modulatory effect of angiotensin-(1–7) via its binding to the Mas receptor (MasR) that attenuates inflammatory response may be a further contributing factor to the hyper-inflammation status of severe cases of COVID-19.”
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A HIGH MOLECULAR WEIGHT FORM OF ANGIOTENSIN I IS GENERATED IN RAT SERUM INCUBATED WITH SYNTHETIC AND NATIVE ANGIOTENSIN I
Lauritzen, E., & Rubin, I. (1984) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1984.tb08635.x · Cited by 1 · see citing works
Food and Water Intake Response of Turkeys to Intracerebroventricular Injections of Angiotensin II
Denbow, D. M. (1985) · Poultry Science · doi:10.3382/ps.0641996 · Cited by 10 · see citing works

Authors: Santos, R. A. S., Sampaio, W. O., Alzamora, A. C., Motta-Santos, D., Alenina, N., Bader, M., & Campagnole-Santos, M. J.
Affiliations: Universidade Federal de Ouro Preto (BR)
National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil; Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil; Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany; Charité - University Medicine, Berlin, Germany; DZHK (German Center for Cardiovascular Research),...
ORCID: Santos, Robson Augusto Souza
Sampaio, Walkyria Oliveira
Motta-Santos, Daisy
Alenina, Natalia
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2018-01-01
Volume: 98
Issue: 1
Pages: 505-553
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00023.2016
PMC: PMC7203574
OpenAlex: W2780715796
Cited by: 1,144
References: 642
Citations by year: 2026: 99 · 2025: 95 · 2024: 135 · 2023: 128 · 2022: 156 · 2021: 222 · 2020: 234 · 2019: 53 · 2018: 21
FWCI: 11.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Physiological Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Funders: Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) (573924/2008-2, 465612/2014-8, 400990/2012-1, 407352/2013-9)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: angiotensin-(1-7), renin-angiotensin system, ACE2, Mas receptor, angiotensin II, angiotensin I, angiotensin-converting enzyme, cardiovascular regulation, brain, heart, kidney
MeSH terms: Angiotensin-Converting Enzyme 2, Proto-Oncogene Mas, Angiotensin I, Animals, Brain, Humans, Peptidyl-Dipeptidase A, Peptide Fragments, Proto-Oncogene Proteins, Renin-Angiotensin System, Signal Transduction, Receptors, G-Protein-Coupled

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The ACE2/angiotensin-(1-7)/MAS Axis of the renin-angiotensin system: focus on angiotensin-(1-7)

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