Altered circulating levels of matrix metalloproteinases 2 and 9 and their inhibitors and effect of progesterone supplementation in women with endometriosis undergoing in vitro fertilization
Open accessAbstract
Objective To investigate differences in the activity of matrix metalloproteinases (MMPs) 2 and 9 and their respective tissue inhibitors (TIMPs) in follicular fluid of women with endometriosis, to correlate the findings with IVF outcome, and to examine the therapeutic potential of progesterone supplementation in restoring the fine balance between MMPs and TIMPs.Design Prospective case-control clinical study.Setting Infertility clinic and reproductive health research unit.Patient(s) A total of 340 infertile women undergoing IVF.Intervention(s) Natural micronized progesterone capsules were administered for luteal support.Main outcome measure(s) Association of MMPs 2 and 9 and TIMP-1 with oocyte maturity and embryo development.Result(s) An abnormal expression of MMP-2, MMP-9, and TIMP-1 with extensive MMP-9/TIMP-1 imbalance in women with endometriosis undergoing IVF was observed. Transforming growth factor β1 plays an important role in these women with possible involvement of Smad-2 and -3 proteins. Progesterone supplementation improves the imbalance in MMP-9/TIMP-1 ratio significantly in women with endometriosis who conceive after IVF.Conclusion(s) Increase in MMP-2 and -9 and decrease in TIMP-1 expression was associated with poor oocyte and embryo development in women with endometriosis undergoing IVF. MMP-9/TIMP-1 balance was highly affected in these women, and progesterone supplementation appeared to restore this imbalance to a considerable degree.
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MMP-2 and MMP-9 have been found to be significantly increased in endometriosis patients versus controls.
“MMP-2 [63] and MMP-9 [64] have been found to be significantly increased in endometriosis patients versus controls.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [64]
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Update on biomarkers for the detection of endometriosis
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“MMP-2 [63] and MMP-9 [64] have”
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- Authors
- Singh, A. K., Chattopadhyay, R., Chakravarty, B., & Chaudhury, K.
- Affiliations
- Indian Institute of Technology Kharagpur (IN)
- Institute of Reproductive Medicine (IN)
- Corresponding author
- Chaudhury, Koel
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 100
- Issue
- 1
- Pages
- 127-134.e1
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1991673163
- Cited by
- 44
- References
- 35
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 5
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Indian Council of Medical Research (3/1/JRF/88/MPD-2007)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- endometriosis, MMP-2, MMP-9, TIMP-1, progesterone supplementation, in vitro fertilization, follicular fluid, oocyte maturity, embryonic development, TGF-β1, Smad2, Smad3, luteal phase support, infertility
- MeSH terms
- Adult, Endometriosis, Female, Fertilization in Vitro, Humans, Pregnancy, Progesterone, Prospective Studies, Biomarkers, Case-Control Studies, Tissue Inhibitor of Metalloproteinase-1, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Matrix Metalloproteinase Inhibitors
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