Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan
Open accessAbstract
Objective To evaluate the relationship between frozen-thawed single blastocyst transfer (BT) and maternal and neonatal outcomes of pregnancy.Design Retrospective analysis.Setting Japanese nationwide registry of assisted reproductive technology (ART) with mandatory reporting for all ART clinics in Japan.Patient(s) Registered from 2008 through 2010 undergoing single embryo transfer cycles (n = 277,042).Intervention(s) None.Main outcome measure(s) Rates of preterm birth (PTB; <37 weeks' gestation), low birth weight (LBW; <2,500 g), small for gestational age (SGA), large for gestational age (LGA), placenta previa, placenta abruption, placenta accreta, and pregnancy-induced hypertension (PIH) after fresh/frozen-thawed and cleaved-embryo/blastocyst transfers were performed.Result(s) Frozen-thawed embryo transfer (FET) was associated with a significantly reduced occurrence of PTB, LBW, and SGA but increased rate of LGA. FET was also associated with a higher incidence of placenta accreta (odds ratio 3.16) and PIH (odds ratio 1.58). BT was associated with a significantly decreased rate of SGA and increased rate of LGA. There was no significant association between BT and maternal complications.Conclusion(s) Frozen-thawed BT is associated with improved general perinatal outcomes of pregnancy but significantly increased maternal risks of placenta accreta and PIH. This finding requires further investigation to assure maternal safety of patients undergoing ART treatment.
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Other additional risk factors for placenta accreta spectrum include maternal age and ART, in particular in vitro fertilisation.
“Other additional risk factors include maternal age 110,113,117,120 and ART, in particular in vitro fertilisation.113,120,122-125”
From Placenta Praevia and Placenta Accreta: Diagnosis and Management: Green‐top Guideline No. 27a (2019) · cites this paper as [124]
Table 4 associates frozen-thawed embryo transfer with higher odds of placenta accreta than fresh transfer among pregnancies after assisted reproduction. It does not establish IVF or ART as a risk factor relative to pregnancies without ART. The same table finds no association between maternal age and placenta accreta (adjusted odds ratio 0.99, 95% CI 0.94–1.05). (LLM, conf=0.88)
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Zegers-Hochschild, F., Adamson, G. D., de Mouzon, J., Ishihara, O., Mansour, R. T., Nygren, K. G., Sullivan, E., & Vanderpoel, S. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.09.009 · Cited by 1,848 · see citing works
Self-citationRoque, M., Lattes, K., Serra, S., Solà, I., Geber, S., Carreras, R., & Checa, M. Á. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.09.003 · Cited by 543 · see citing works
Zegers-Hochschild, F., Mansour, R., Ishihara, O., Adamson, G. D., de Mouzon, J., Nygren, K. G., & Sullivan, E. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.10.005 · Cited by 540 · see citing works
Self-citationMaheshwari, A., Pandey, S., Shetty, A., Hamilton, M., & Bhattacharya, S. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.05.019 · Cited by 513 · see citing works
Sullivan, E., Zegers-Hochschild, F., Mansour, R. T., Ishihara, O., de Mouzon, J., Nygren, K. G., & Adamson, G. D. (2013) · Human Reproduction · doi:10.1093/humrep/det036 · Cited by 416 · see citing works
Self-citationObstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos
Sazonova, A. P., Källén, K., Thurin‐Kjellberg, A., Wennerholm, U. B., & Bergh, C. (2012) · Human Reproduction · doi:10.1093/humrep/des036 · Cited by 254 · see citing works
Chang, H. J., Lee, J. R., Jee, B. C., Suh, C. S., & Kim, S. H. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.066 · Cited by 180 · see citing works
Obstetric outcomes after transfer of vitrified blastocysts
Wikland, M., Hardarson, T., Hillensjø, T., Westin, C., Westlander, G., Wood, M., & Wennerholm, U. (2010) · Human Reproduction · doi:10.1093/humrep/deq117 · Cited by 176 · see citing works
Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis
Grady, R., Alavi, N., Vale, R., Khandwala, M., & McDonald, S. D. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.11.033 · Cited by 174 · see citing works
Källén, B. A. J., Finnström, O., Lindam, A. P., Nilsson, E. M. E., Nygren, K., & Olausson, P. O. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.12.027 · Cited by 160 · see citing works
Shapiro, B. S., Daneshmand, S. T., Restrepo, H., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.09.044 · Cited by 152 · see citing works
Dar, S., Librach, C. L., Gunby, J. L., et al. (2013) · Human Reproduction · doi:10.1093/humrep/des448 · Cited by 124 · see citing works
Nakashima, A., Araki, R., Tani, H., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.09.027 · Cited by 104 · see citing works
Self-citationIshihara, O., Kuwahara, A., & Saitoh, H. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.02.015 · Cited by 98 · see citing works
Self-citationFernando, D., Halliday, J. L., Breheny, S., & Healy, D. L. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.12.032 · Cited by 97 · see citing works
Blastocyst embryo transfer is associated with a sex-ratio imbalance in favor of male offspring
Luna, M., Duke, M., Copperman, A. B., Grunfeld, L., Sandler, B., & Barritt, J. A. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.06.058 · Cited by 88 · see citing works
Maternal age and placenta previa: A population-based, case-control study
Zhang, J., & Savitz, D. A. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90511-g · Cited by 80 · see citing works
Blastocyst culture and transfer in clinical-assisted reproduction: a committee opinion
(2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.01.087 · Cited by 74 · see citing works
Cumulative Live-Birth Rates in a Trial of Single-Embryo or Double-Embryo Transfer
Thurin‐Kjellberg, A., Olivius, C., & Bergh, C. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0907289 · Cited by 29 · see citing works
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Research works printed but not linked: 1
- [11]11. Itabashi K, et al. New standard of average size and weight of newborn in Japan. Jap J Pediat 2010;114:1271-93.
Cited by
Sorted by citations
Placenta Praevia and Placenta Accreta: Diagnosis and Management: Green‐top Guideline No. 27a
Jauniaux, E., Alfirevic, Z., Bhide, A., Belfort, M., Burton, G., Collins, S., Dornan, S., Jurkovic, D., Kayem, G., Kingdom, J., et al. (2019) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15306 · Cited by 506 · see citing works
<scp>FIGO</scp> consensus guidelines on placenta accreta spectrum disorders: Epidemiology,
Jauniaux, E., Chantraine, F., Silver, R. M., Langhoff‐Roos, J., & Panel, F. T. F. P. A. D. A. M. E. C. (2018) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12407 · Cited by 498 · see citing works
Cryopreserved embryo transfer is an independent risk factor for placenta accreta
Kaser, D. J., Melamed, A., Bormann, C. L., Myers, D. E., Missmer, S. A., Walsh, B. W., Racowsky, C., & Carusi, D. A. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.01.021 · Cited by 188 · see citing works
Ishihara, O., Jwa, S. C., Kuwahara, A., Katagiri, Y., Kuwabara, Y., Hamatani, T., Harada, M., & Ichikawa, T. (2020) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12307 · Cited by 63 · see citing works
Self-citationKorosec, S., Ban Frangez, H., Verdenik, I., Kladnik, U., Kotar, V., Virant-Klun, I., & Vrtacnik Bokal, E. (2014) · BioMed Research International · doi:10.1155/2014/431797 · Cited by 50 · see citing works
- Authors
- Ishihara, O., Araki, R., Kuwahara, A., Itakura, A., Saito, H., & Adamson, G. D.
- Affiliations
- Saitama Medical University (JP)
- Tokushima University (JP)
- National Center For Child Health and Development (JP)
- Corresponding author
- Ishihara, Osamu
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 101
- Issue
- 1
- Pages
- 128-133
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1974978813
- Cited by
- 383
- References
- 19
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 39 · 2023: 31 · 2022: 36 · 2021: 50 · 2020: 48 · 2019: 37 · 2018: 37 · 2017: 32 · 2016: 23 · 2015: 16 · 2014: 11
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-04-01)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- frozen embryo transfer, single blastocyst transfer, single embryo transfer, preterm birth, low birth weight, small for gestational age, large for gestational age, placenta accreta, placenta previa, placental abruption, gestational hypertension, maternal complications, neonatal outcomes, assisted reproduction
- MeSH terms
- Adult, Embryo Transfer, Female, Follow-Up Studies, Humans, Infant, Newborn, Japan, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Registries, Retrospective Studies, Cryopreservation, Single Embryo Transfer
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