Endometriosis may not be a chronic disease: an alternative theory offering more optimistic prospects for our patients
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Progression of subtle lesions or progression from typical to cystic or deep lesions has not been observed directly.
“However, progression of subtle lesions or progression from typical to cystic or deep lesions has not been observed directly (56).”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [56]
Deep endometriosis seems to be reactivated by trauma, such as by in vitro fertilization-related needle punctures for oocyte pick-up, triggering the subsequent development of more severe lesions and even a frozen pelvis.
“Although the mechanisms of reactivation are not understood, deep endometriosis seems to be reactivated by trauma, such as by in vitro fertilization-related needle punctures for oocyte pick-up, triggering the subsequent development of more severe lesions and even a frozen pelvis (56), as frequently observed.”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [56]
Progression from subtle to more severe lesions, or from typical to cystic or deep, or from cystic to deep has never been observed and remains speculation.
“However, progression from subtle to more severe lesions, or from typical to cystic or deep, or from cystic to deep has never been observed and remains speculation.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [63]
Endometriosis is erroneously considered a progressive disease.
“Endometriosis is-erroneously (63)-considered a progressive disease.”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [63]
When traumatized by clinical examination or by puncture for oocyte pick-up, deep endometriosis lesions seem to be activated and might start growing again.
“However, when traumatized by clinical examination or by puncture for oocyte pick-up, deep endometriosis lesions seem to be activated and might start growing again (63).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [63]
Cites
A new concept of endometriosis and adenomyosis, tissue injury and repair (TIAR)
Leyendecker, G., & Wildt, L. (2011) · hmbci · doi:10.1515/hmbci.2011.002 · Cited by 147 · see citing works
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Managing female sexual dysfunction
Buster, J. E. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.026 · Cited by 104 · see citing works
Is adolescent endometriosis a progressive disease that needs to be diagnosed and treated?
(Hans) Evers, J. L. H. (2013) · Human Reproduction · doi:10.1093/humrep/det298 · Cited by 65 · see citing works
Endometriosis: the consequence of uterine denervation–reinnervation
Quinn, M. J. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-011-2063-y · Cited by 35 · see citing works
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Pathogenesis of endometriosis: The genetic/epigenetic theory
Koninckx, P. R., Ussia, A., Adamyan, L., Wattiez, A., Gomel, V., & Martin, D. C. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.10.013 · Cited by 427 · see citing works
Pathogenesis of deep endometriosis
Gordts, S., Koninckx, P., & Brosens, I. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.036 · Cited by 241 · see citing works
Bowel Endometriosis: Current Perspectives on Diagnosis and Treatment
Habib, N., Centini, G., Lazzeri, L., Amoruso, N., Khoury, L. E., Zupi, E., & Afors, K. (2020) · International Journal of Women s Health · doi:10.2147/ijwh.s190326 · Cited by 75 · see citing works
Martire, F. G., Giorgi, M., d’Abate, C., Colombi, I., Ginetti, A., Cannoni, A., Fedele, F., Exacoustós, C., Centini, G., Zupi, E., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020550 · Cited by 58 · see citing works
Clinical Diagnosis and Early Medical Management for Endometriosis: Consensus from Asian Expert Group
Kim, M.-R., Chapron, C., Römer, T., Aguilar, A., Chalermchockcharoenkit, A., Chatterjee, S., Đào, L. T. A., Fong, Y. F., Hendarto, H., Hidayat, S. T., et al. (2022) · Healthcare · doi:10.3390/healthcare10122515 · Cited by 42 · see citing works
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Canis, M. J., Bourdel, N., Houlle, C., Grémeau, A.-S., Botchorishvili, R., & Matsuzaki, S. (2017) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2016.12.008 · Cited by 27 · see citing works
Self-citationElbaradie, S. M. Y., Bakry, M. S., & Bosilah, A. H. (2020) · BMC Women s Health · doi:10.1186/s12905-020-01051-0 · Cited by 14 · see citing works
Stratégies diagnostiques dans l’endométriose, RPC Endométriose CNGOF-HAS
Bourdel, N., Chauvet, P., & Canis, M. J. (2018) · Gynécologie Obstétrique Fertilité & Sénologie · doi:10.1016/j.gofs.2018.02.008 · Cited by 10 · see citing works
Self-citationRisk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over
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Endometriosis Influencers on Instagram: Who Are They and What Are They Posting?
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The Genetic-Epigenetic Pathophysiology of Endometriosis: A Surgeon’s View
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Self-citationEndométriose : information aux patientes – il faut arrêter la machine à faire peur !
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Karakaş, E., Dolanbay, M., Ermiş, M., Akgün, H., Arzu Hanım, Y. A. Y., Köseoğlu, E., & Karaman, E. (2026) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-026-00510-8
- Authors
- Canis, M., Bourdel, N., Houlle, C., Gremeau, A. S., Botchorishvili, R., & Matsuzaki, S.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 105
- Issue
- 1
- Pages
- 32-34
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2211346714
- Cited by
- 21
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2022: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, chronic pelvic pain, disease pathophysiology, retrograde menstruation, metaplasia, stem cells, Müllerianosis, treatment outcomes, quality of life
- MeSH terms
- Chronic Disease, Disease Susceptibility, Endometriosis, Female, Humans, Phenotype, Recurrence, Risk Factors, Severity of Illness Index, Treatment Outcome, Disease Progression
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