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Cited by 106Reproductive Health and TechnologiesObesity, Physical Activity, DietOvarian function and disorders

The DOI matches its Crossref record; 54 of the 55 references it cites were found in a registry or an index.

Body mass index, physical activity and fecundability in a North American preconception cohort study

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McKinnon, Craig J., Hatch, Elizabeth E., Rothman, Kenneth J., Mikkelsen, Ellen M., Wesselink, Amelia K., Hahn, Kristen A., Wise, Lauren A.·2016·Fertility and Sterility
DOI 10.1016/j.fertnstert.2016.04.011
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Abstract

Objective To evaluate the association between adiposity, physical activity (PA), and fecundability.Design Prospective cohort study.Setting Not applicable.Patient(s) A total of 2,062 female pregnancy planners from the United States and Canada who were enrolled during the preconception period.Intervention(s) None.Main outcome measure(s) Self-reported pregnancy. Fecundability ratios (FRs) and 95% confidence intervals (CIs) were estimated using proportional probabilities models that adjusted for potential confounders.Result(s) Relative to body mass index (BMI) 18.5-24 kg/m(2), FRs for BMI <18.5, 25-29, 30-34, 35-39, 40-44, and ≥45 kg/m(2) were 1.05 (95% CI 0.76-1.46), 1.01 (95% CI 0.89-1.15), 0.98 (95% CI 0.82-1.18), 0.78 (95% CI 0.60-1.02), 0.61 (95% CI 0.42-0.88), and 0.42 (95% CI 0.23-0.76), respectively. Reduced fecundability was observed among women with the largest waist-to-hip ratios (≥0.85 vs. <0.75; FR = 0.87, 95% CI 0.74-1.01) and waist circumferences (≥36 vs. <26 inches [≥90 vs. <66 cm]; FR = 0.80, 95% CI 0.59-1.01). Tendency to gain weight in the chest/shoulders (FR = 0.63, 95% CI 0.36-1.08) and waist/stomach (FR = 0.90, 95% CI 0.79-1.02), relative to hips/thighs, was associated with lower fecundability. Moderate PA was associated with increased fecundability (≥5 vs. <1 h/wk; FR = 1.26, 95% CI 0.96-1.65), but there was no dose-response relation. Among overweight/obese women (BMI ≥25 kg/m(2)), fecundability was 27% higher for vigorous PA of ≥5 versus <1 h/wk (95% CI 1.02-1.57).Conclusion(s) Various measures of overall and central adiposity were associated with decreased fertility among pregnancy planners. Vigorous PA was associated with improved fertility among overweight and obese women only; moderate PA was associated with improved fertility among all women.

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  1. 1995, Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee, World Health Organ Tech Rep Ser, 854, 1

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Metadata

Authors
McKinnon, C. J., Hatch, E. E., Rothman, K. J., Mikkelsen, E. M., Wesselink, A. K., Hahn, K. A., & Wise, L. A.
Affiliations
  • Boston University (US)
  • Aarhus University Hospital (DK)
Corresponding author
McKinnon, Craig J.
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2016-08
Volume
106
Issue
2
Pages
451-459
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2016.04.011
OpenAlex
W2343672789
Cited by
106
References
55
Citations by year
2026: 6 · 2025: 7 · 2024: 14 · 2023: 9 · 2022: 10 · 2021: 18 · 2020: 18 · 2019: 4 · 2018: 13 · 2017: 3 · 2016: 4
FWCI
10.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Scopus (Elsevier) (submittedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD072326, T32HD052458)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords
fecundability, body mass index, adiposity, physical activity, obesity, waist-to-hip ratio, waist circumference, preconceptions, pregnancy planning, female fertility, subcutaneous adipose tissue, visceral fat, North America, Canada, United States, miscarriage, assisted reproduction
MeSH terms
Adult, Canada, Female, Fertility, Health Status, Humans, Infertility, Female, Obesity, Pregnancy, Prospective Studies, Risk Factors, United States, Exercise, Body Mass Index, Women's Health, Adiposity, Young Adult, Self Report, Reproductive Health, Time-to-Pregnancy

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