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Cited by 168Endometriosis Research and TreatmentOvarian function and disordersReproductive Biology and Fertility

Antimüllerian hormone is reduced in the presence of ovarian endometriomas: a systematic review and meta-analysis

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Muzii, Ludovico, Di Tucci, Chiara, Di Feliciantonio, Mara, Galati, Giulia, Di Donato, Violante, Musella, Angela, Palaia, Innocenza, Panici, Pierluigi Benedetti·2018·Fertility and Sterility
DOI 10.1016/j.fertnstert.2018.06.025
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Abstract

Objective To evaluate if the presence of endometriomas impacts on the ovarian reserve as evaluated with antimüllerian hormone (AMH). Design Systematic review and meta-analysis. Setting Not applicable. Patient(s) Patients with unoperated endometriomas versus controls without endometriomas. Intervention(s) Electronic databases searched up to June 2017 to identify articles evaluating AMH levels in patients with unoperated endometriomas versus controls without endometriomas. Main outcome measure(s) The primary analysis was aimed at evaluation of AMH levels (mean and SD) in patients with and without endometriomas. Secondary analyses were aimed at evaluating AMH levels in patients with ovarian endometriomas compared to patients with either non-endometriosis benign ovarian cysts or healthy ovaries. Result(s) Of the 39 studies evaluated in detail, 17 were included, for a total of 968 patients with endometriomas and 1874 without endometriomas. AMH was significantly lower in patients with unoperated endometriomas compared to patients with no endometriomas (mean difference -0.84, with 95% confidence interval [CI] -1.16 to -0.52). At secondary analyses, AMH in patients with endometriomas was significantly lower both versus non-endometriosis benign ovarian cysts (mean difference -0.85, 95% CI -1.37 to -0.32, and versus women with healthy ovaries (mean difference -0.61, 95% CI -0.99 to -0.24). Conclusion(s) Ovarian reserve evaluated with AMH is reduced in patients with ovarian endometrioma…

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Crossref · 10.1016/j.fertnstert.2018.06.025

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  • Women with endometriosis demonstrate reduced serum AMH relative to control subjects.

    “Women with endometriosis demonstrate reduced serum AMH relative to control subjects (Dong et al., 2019; Kasapoglu et al., 2018; Muzii et al., 2018; Romanski et al., 2019; Sánchez‐Ferrer et al., 2019; Shebl et al., 2009).”

    From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Muzii et al., 2018

  • Women with endometriosis who do not undergo surgery also show accelerated declines in AMH levels relative to unaffected women.

    “Women with endometriosis treated with ovarian surgery demonstrate an especially steep decline in AMH levels, but women with endometriosis who do not undergo surgery also show accelerated declines in AMH levels relative to unaffected women (Goodman et al., 2016; Kasapoglu et al., 2018; Muzii et al., 2018; Romanski et al., 2019).”

    From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Muzii et al., 2018

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Authors
Muzii, L., Di Tucci, C., Di Feliciantonio, M., Galati, G., Di Donato, V., Musella, A., Palaia, I., & Panici, P. B.
Affiliations
Sapienza University of Rome (IT)
Corresponding author
Muzii, Ludovico
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2018-10
Volume
110
Issue
5
Pages
932-940.e1
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2018.06.025
OpenAlex
W2896685552
Cited by
168
References
4
Citations by year
2026: 20 · 2025: 31 · 2024: 24 · 2023: 18 · 2022: 23 · 2021: 24 · 2020: 15 · 2019: 11 · 2018: 2
FWCI
1.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
anti-Müllerian hormone, endometrioma, ovarian reserve, endometriosis, benign ovarian cysts, ovarian function
MeSH terms
Endometriosis, Female, Humans, Ovarian Cysts, Prospective Studies, Retrospective Studies, Biomarkers, Randomized Controlled Trials as Topic, Anti-Mullerian Hormone, Ovarian Reserve

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