B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population
Open accessAbstract
Objective To determine whether increased endometrial B-cell lymphoma 6 (BCL6) expression is associated with live birth in a normal responder in vitro fertilization (IVF) population.Design Case-control study.Setting University-affiliated infertility center.Patient(s) Two groups of women undergoing IVF with preimplantation genetic testing for aneuploidy followed by warmed, single, euploid embryo transfer. Group 1 consisted of women who failed to achieve live birth, and group 2 consisted of women who achieved live birth.Intervention(s) None.Main outcome measure(s) Endometrial BCL6 expression measured by immunohistochemistry in endometrial tissue samples. Overexpression was defined by mean HSCORE with a cutoff of positivity of >1.4, as previously described in the literature.Result(s) Twenty-seven patients who achieved live birth and 23 patients who failed to achieve live birth were included. B-cell lymphoma 6 expression/HSCORE and live birth rate were not associated (Odds ratio [OR], 0.78 [0.24-2.55]). Using a cutoff of >1.4 for positivity, 8 of 23 samples were positive for BCL6 in the no live birth group, whereas 7 of 27 were positive in the live birth group. There was no significant association between BCL6 positivity and live birth (OR, 0.66 [0.19-2.21]).Conclusion(s) The proportion of patients with BCL6 positivity did not significantly differ between those who achieved live birth and those who did not. In the population of patients at our center, who compromise of women who respond normally to IVF stimulation, BCL6 overexpression was not associated with IVF success. Physicians implementing BCL6 testing as a diagnostic tool for clinical decision making should counsel patients that results may have limited utility in predicting IVF outcomes in this population.
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BCL6 overexpression in the endometrium did not truly predict endometrial receptivity when frozen euploid blastocysts were transferred.
“This too failed to truly predict endometrial receptivity when frozen euploid blastocysts were transferred.”
From Endometrial receptivity in adenomyosis and/or endometriosis (2023) · cites this paper as [16]
In patients with BCL6-positive biopsies, embryo implantation and live birth rates did not significantly differ from those with BCL6-negative biopsies.
“Klimczak et al. (16) reported that embryo implantation and live birth rates (LBRs) in patients with BCL6 positive biopsies did not significantly differ from those in patients whose biopsies were negative.”
From Endometrial receptivity in adenomyosis and/or endometriosis (2023) · cites this paper as [16]
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Endometrial receptivity in adenomyosis and/or endometriosis
Pirtea, P., de Ziegler, D., & Ayoubi, J. M. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2023.03.004 · Cited by 65 · see citing works
- Authors
- Klimczak, A. M., Herlihy, N. S., Scott, C. S., Hanson, B. M., Kim, J. G., Titus, S., Seli, E., & Scott, R. T.
- Affiliations
- Reproductive Medicine Associates of New Jersey (US)
- Yale University (US)
- Corresponding author
- Klimczak, Amber M.
- ORCID
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 117
- Issue
- 2
- Pages
- 351-358
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W3215120206
- Cited by
- 24
- References
- 30
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 9 · 2022: 4
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- B-cell lymphoma 6, endometrium, in vitro fertilization, live birth, IVF outcome prediction, normal responders, preimplantation genetic testing for aneuploidy, embryo transfer, endometrial biomarkers
- MeSH terms
- Adolescent, Adult, Endometrium, Female, Fertility, Fertilization in Vitro, Humans, Infertility, Male, Embryo Implantation, Pregnancy, Risk Factors, Time Factors, Case-Control Studies, Treatment Outcome, Risk Assessment, Pregnancy Rate, Live Birth, Proto-Oncogene Proteins c-bcl-6, Young Adult, Single Embryo Transfer
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