Factors affecting live birth rates in donor oocytes from commercial egg banks vs. program egg donors: an analysis of 40,485 cycles from the Society for Assisted Reproductive Technology registry in 2016-2018
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Objective To examine the differences in live birth rates (LBRs), with single embryo transfer (SET), using oocytes from program generated egg donors vs. commercial egg bank donors and other factors affecting LBRs using donor oocytes.Design Retrospective cohort study.Setting Not applicable.Patient(s) A total of 40,485 in vitro fertilization cycles using donor oocytes reported to the Society for Assisted Reproductive Technology registry in 2016-2018.Intervention(s) None.Main outcome measure(s) Live birth rate and cumulative LBR for SET using donor oocytes.Result(s) Multivariate results from the first SET from 19,128 cycles, including 15,429 from program generated egg donors and 3,699 from commercial egg banks, showed, when controlling for all other variables, the following: the LBR in the first SET cycle using commercial egg banks was 53.3% compared with 55.4% using program recruited egg donors (odds ratio [OR], 0.92); a reduction in the LBR with increasing recipient age, ages 40-44 years (OR, 0.80), 45-49 years (OR, 0.77), and >49 years (OR, 0.65); a steady decline in the LBR with increases in recipient body mass index above normal; and a steady increase in the LBR in association with >16 oocytes retrieved. Double embryo transfer increased the LBR (SET, 52%, vs. double embryo transfer, 58%) but also significantly increased the multiple pregnancy LBR, with 43% twins and 0.9% triplets. Blastocyst transfer had a higher LBR than cleavage stage embryos (52.5% vs. 39.5%). Intracytoplasmic sperm injection vs. conventional insemination when using fresh oocytes from program donors had similar LBRs.Conclusion(s) When performing in vitro fertilization using donor oocytes with SET, the LBR is affected by oocyte source, recipient age, recipient body mass index, stage of embryo at transfer, and number of oocytes retrieved.
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- Authors
- Williams, R. S., Ellis, D. D., Wilkinson, E. A., Kramer, J. M., Datta, S., & Guzick, D. S.
- Affiliations
- University of Florida Health (US)
- University of Florida (US)
- Corresponding author
- Williams, Robert Stan
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 117
- Issue
- 2
- Pages
- 339-348
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W3201276102
- Cited by
- 21
- References
- 20
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 2
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Florida
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- live birth rate, donor oocytes, single embryo transfer, in vitro fertilization, recipient age, body mass index, oocyte retrieval number, double embryo transfer, multiple pregnancy, blastocyst transfer, intracytoplasmic sperm injection
- MeSH terms
- Adult, Female, Fertility, Fertilization in Vitro, Humans, Infertility, Male, Maternal Age, Middle Aged, Pregnancy, Registries, Retrospective Studies, Risk Factors, Societies, Medical, Cryopreservation, Body Mass Index, Treatment Outcome, Biological Specimen Banks, Risk Assessment, Oocyte Donation, Live Birth, Oocyte Retrieval, Single Embryo Transfer
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