Evidence for recombination in Candida glabrata.
Abstract
Despite its clinical importance, little is known of the epidemiology and population structure of Candida glabrata. C. glabrata possesses a mating type system similar to that in Saccharomyces cerevisiae, however mating, meiosis and recombination have not been demonstrated. We performed multilocus sequence typing on a collection of 165 isolates to test for evidence of genetic recombination. A total of 3345 bp from six loci (FKS, LEU2, NMT1, TRP1, UGP1, and URA3) were sequenced for each isolate. The polymorphisms at these loci defined 34 sequence types. Significant evidence for a clonal population was revealed by the index of association and the number of phylogenetically compatible pairs of loci. However, 14 examples of phylogenetic incompatibility were also found. Thus we conclude that although C. glabrata has a predominantly clonal population structure, the multiple phylogenetic incompatibilities found strongly suggest that recombination occurred during the evolution of C. glabrata, and may infrequently still occur.
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Genetically diverse C. glabrata lineages can recombine, leading to genetic admixture.
“Another ability of C. glabrata that has been confirmed recently, using comparison of whole genome sequences, is that genetically diverse lineages can recombine, leading to genetic admixture (Dodgson et al., 2005; Carreté et al., 2018).”
From Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations (2019) · cites this paper as Dodgson et al., 2005
The high relationship between DSY562 and DSY565 was confirmed by MLST typing.
“Before undertaking genome sequencing, both isolates were subjected to MLST typing according to Dodgson et al. (2005) (Table 1), and thus the high relationship between both isolates was confirmed.”
From Comparative Genomics of Two Sequential <i>Candida glabrata</i> Clinical Isolates (2017) · cites this paper as Dodgson et al. (2005)
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References 30 · Cited by 69
- Authors
- Dodgson, A. R., Pujol, C., Pfaller, M. A., Denning, D. W., & Soll, D. R.
- Affiliations
- University of Iowa (US)
- University of Manchester (GB)
- Corresponding author
- Soll, David R.
- Venue
- Fungal Genetics and Biology
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 42
- Issue
- 3
- Pages
- 233-243
- ISSN
- 1087-1845 (ISSN-L)
- OpenAlex
- W2108566050
- Cited by
- 69
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 10 · 2013: 2 · 2012: 2
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fungal Genetics and Biology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (DE014219, R01DE014219)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Candida glabrata, genetic recombination, population structure, clonal populations, multilocus sequence typing, fungal evolution, sequence types
- MeSH terms
- Chromosome Mapping, Crosses, Genetic, Karyotyping, Meiosis, Molecular Sequence Data, Phylogeny, Recombination, Genetic, Candida glabrata
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