In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes
Abstract
By using an agar dilution assay, the antifungal activity of aqueous extracts prepared from Allium cepa (onion; AOE) and Allium sativum (garlic; AGE) were evaluated against Malassezia furfur (25 strains), Candida albicans (18 strains), other Candida sp. (12 strains) as well as 35 strains of various dermatophyte species and compared with the activity of a known antifungal drug, ketoconazole (KTZ). All the AOE, AGE and KTZ were found to be able to inhibit growth of all fungi tested in a dose-dependent manner with maximum of 100% at defined concentrations. The results indicate that onion and garlic might be promising in treatment of fungal-associated diseases from important pathogenic genera Candida, Malassezia and the dermatophytes.
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The current results and previous findings support the potential utilization of Allium spp. (wild and traditional type) extracts against fungi and other microbial pathogens.
“The current results and the previous findings of other scientist support the potential utilization of Allium spp. (wild and traditional type) extracts against fungi and other microbial pathogens22–24.”
From Bioactivities of Allium longicuspis Regel against anthracnose of mango caused by Colletotrichum gloeosporioides (Penz.) (2020) · cites this paper as [24]
Cites
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de Guzman Alvindia, D., & Mangoba, M. A. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-68399-z · Cited by 18 · see citing works
- Authors
- Shams-Ghahfarokhi, M., Shokoohamiri, M.-R., Amirrajab, N., Moghadasi, B., Ghajari, A., Zeini, F., Sadeghi, G., & Razzaghi-Abyaneh, M.
- Affiliations
- Tarbiat Modares University (IR)
- Shahid Beheshti University (IR)
- Tehran University of Medical Sciences (IR)
- Pasteur Institute of Iran (IR)
- ORCID
- Amirrajab, Nasrin
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 77
- Issue
- 4
- Pages
- 321-323
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W2078332237
- Cited by
- 134
- References
- 4
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 16 · 2018: 5 · 2017: 10 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 7 · 2012: 7
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- antifungal activity, onion, garlic, aqueous plant extract, ketoconazole, Malassezia furfur, Candida albicans, Candida, dermatophytes, pathogenic yeasts, fungal infection, antifungal natural products
- MeSH terms
- Antifungal Agents, Candida, Dermatomycoses, Arthrodermataceae, Garlic, Humans, Ketoconazole, Malassezia, Phytotherapy, Microbial Sensitivity Tests, Plant Extracts, Onions
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