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Antioxidant activity of hydroxycinnamic acid derivatives in human low density lipoprotein: Mechanism and structure–activity relationship
Open accessAbstract
Hydroxycinnamic acid derivatives, i.e., caffeic acid (CaA), chlorogenic acid (ChA), sinapic acid (SA), ferulic acid (FA) and p-coumaric acid (CoA), are widely distributed in plants and are known antioxidants. The in vitro peroxidation of human low density lipoprotein (LDL) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of hydroxycinnamic acid derivatives. The peroxidation was initiated either by a water-soluble azo-initiator 2, 2''azobis(2-amidinopropane hydrochloride) (AAPH), or by cupric ion (Cu2+). The reaction kinetics were monitored either by the uptake of oxygen or by the formation of thiobarbituric acid reactive substances (TBARS). Kinetic analysis of the antioxidation process demonstrates that these hydroxycinnamic acid derivatives are effective antioxidants against both AAPH- and Cu2+-induced LDL peroxidation with the activity sequence of CaA approximately ChA > SA > FA > CoA, and CaA approximately ChA > SA approximately FA approximately CoA, respectively. Molecules bearing ortho-dihydroxyl or 4-hydroxy-3-methoxyl groups possess significantly higher antioxidant activity than those bearing no such functionalities.
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“Phenolics are beneficial for human health, preventing cardiovascular disease, cancer, diabetes, and obesity [95,96], and are used to inhibit lipid oxidation and fungal and bacterial growth in food [97].”
From Potential Valorization of Banana Production Waste in Developing Countries: Bio-Engineering Aspects (2024) · cites this paper as [96]
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Metadata
- Authors
- Cheng, J.-C., Dai, F., Zhou, B., Yang, L., & Liu, Z.-L.
- Affiliations
- Lanzhou University (CN)
- Corresponding author
- Zhou, Bo
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 104
- Issue
- 1
- Pages
- 132-139
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2003700636
- Cited by
- 205
- References
- 47
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 11 · 2023: 6 · 2022: 13 · 2021: 11 · 2020: 12 · 2019: 8 · 2018: 15 · 2017: 14 · 2016: 13 · 2015: 12 · 2014: 11 · 2013: 14 · 2012: 13
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- green
- 202.201.7.4:8080
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Food Chemistry (publishedVersion)
- Lanzhou University Institutional Repository (submittedVersion, cc-by-nc-nd)
- Funders
- National Natural Science Foundation of China
- Chinese Academy of Agricultural Sciences
- Anhui University of Science and Technology
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- hydroxycinnamic acid derivatives, antioxidant activity, LDL peroxidation, structure-activity relationship, caffeic acid, chlorogenic acid, sinapic acid, ferulic acid, p-coumaric acid, copper-induced lipid peroxidation, TBARS
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