The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Nitrate and nitrite quantification from cured meat and vegetables and their estimated dietary intake in Australians
Abstract
High dietary nitrate and nitrite intake may increase the risk of gastro-intestinal cancers due to the in vivo formation of carcinogenic chemicals known as N-nitroso compounds. Water and leafy vegetables are natural sources of dietary nitrate, whereas cured meats are the major sources of dietary nitrite. This paper describes a simple and fast analytical method for determining nitrate and nitrite contents in vegetables and meat, using reversed-phase HPLC-UV. The linearity R ² value was >0.998 for the anions. The limits of quantification for nitrite and nitrate were 5.0 and 2.5mg/kg, respectively. This method is applicable for both leafy vegetable and meat samples. A range of vegetables was tested, which contained <23mg/kg nitrite, but as much as 5000mg/kg of nitrate. In cured and fresh meat samples, nitrate content ranged from 3.7 to 139.5mg/kg, and nitrite content ranged from 3.7 to 86.7mg/kg. These were below the regulatory limits set by food standards Australia and New Zealand (FSANZ). Based on the average consumption of these vegetables and cured meat in Australia, the estimated dietary intake for nitrate and nitrite for Australians were 267 and 5.3mg/adult/day, respectively.
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“However, the dose of nitrite used in that study was 250–350 mg/kg/day, which was too high to compare with those achieved in standard human diets [113].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [113]
Citations
Cites
Gastric cancer: global pattern of the disease and an overview of environmental risk factors
Forman, D., & Burley, V. J. (2006) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2006.04.008 · Cited by 460
Nitrate, nitrite and N-nitroso compounds
Gangolli, S. D., van den Brandt, P. A., Feron, V. J., Janzowsky, C., Koeman, J. H., Speijers, G. J. A., Spiegelhalder, B., Walker, R., & Wishnok, J. S. (1994) · European Journal of Pharmacology: Environmental Toxicology and Pharmacology · doi:10.1016/0926-6917(94)90022-1 · Cited by 380
Dietary Salt, Nitrate and Stomach Cancer Mortality in 24 Countries
Joossens, J. V., Hill, M. J., Elliott, P., Stamler, R., Stamler, J., Lesaffre, E. M. E. H., DYER, A., Nichols, R., & Kesteloot, H. (1996) · International Journal of Epidemiology · doi:10.1093/ije/25.3.494 · Cited by 357
Nitrite and nitrosyl compounds in food preservation
Cammack, R., Joannou, C. L., Cui, X.-Y., Martinez, C. T., Maraj, S. R., & Hughes, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00033-x · Cited by 297
Öztekin, N., Nutku, M. S., & Erim, F. B. (2002) · Food Chemistry · doi:10.1016/s0308-8146(01)00287-4 · Cited by 162
Duncan, C., Li, H., Dykhuizen, R., Frazer, R., Johnston, P., MacKnight, G., Smith, L., Lamza, K., McKenzie, H., Batt, L., et al. (1997) · Comparative Biochemistry and Physiology Part A: Physiology · doi:10.1016/s0300-9629(97)00023-6 · Cited by 147
Ion chromatographic determination of nitrate and nitrite in meat products
Siu, D. C., & Henshall, A. (1998) · Journal of Chromatography A · doi:10.1016/s0021-9673(97)01245-4 · Cited by 134
Simultaneous determination of nitrite and nitrate by normal phase ion-pair liquid chromatography
Butt, S. B. (2001) · Talanta · doi:10.1016/s0039-9140(01)00502-1 · Cited by 123
HANDBOOK OF FOOD ANALYSIS, PHYSICAL CHARACTERIZATION AND NUTRIENT ANALYSIS
Nielsen, S. (2005) · Journal of Food Quality · doi:10.1111/j.1745-4557.2005.00030.x · Cited by 119
Dietary exposure models for nitrates and nitrites
Pennington, J. A. T. (1998) · Food Control · doi:10.1016/s0956-7135(98)00019-x · Cited by 108
Amr, A., & Hadidi, N. (2001) · Journal of Food Composition and Analysis · doi:10.1006/jfca.2000.0950 · Cited by 108
Davis, P. A., & Sano, T. (2001) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(00)00131-1 · Cited by 107
Mechanisms of action of N-nitroso compounds.
Archer, M. C. (1989) · PubMed · Cited by 106
Matteo, V. D., & Esposito, E. (1997) · Journal of Chromatography A · doi:10.1016/s0021-9673(97)00851-0 · Cited by 100
Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology
Bartsch, H., Ohshima, H., Shuker, D. E. G., Pignatelli, B., & Calmels, S. (1990) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(90)90017-6 · Cited by 96
Analysis of nitrate and nitrite in foodstuffs: A critical review
Usher, C. D., & Telling, G. M. (1975) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740261122 · Cited by 90
The Exposure of Humans to Nitrite
Walters, C. L. (2009) · Oncology · doi:10.1159/000225455 · Cited by 76
Reinik, M., Tamme, T., Roasto, M., Juhkam, K., Jurtšenko, S., Tenno, T., & Kiis, A. (2005) · Food Additives & Contaminants · doi:10.1080/02652030500241827 · Cited by 54
Stalikas, C. D., Konidari, C. N., & Nanos, C. G. (2003) · Journal of Chromatography A · doi:10.1016/s0021-9673(03)00735-0 · Cited by 49
The determination of nitrate and nitrite in cured meat by HPLC/UV
Dennis, M. J., Key, P. E., Papworth, T., Pointer, M., & MASSEY, R. C. (1990) · Food Additives & Contaminants · doi:10.1080/02652039009373908 · Cited by 48
N-nitroso compounds in two nitrosated food products in Southwest Korea
Seel, D. J., KAWABATA, T., Nakamura, M., Ishibashi, T., Hamano, M., Mashimo, M., Shin, S., Sakamoto, K., Jhee, E. C., & WATANABE, S. (1994) · Food and Chemical Toxicology · doi:10.1016/0278-6915(94)90127-9 · Cited by 44
The determination of nitrite and nitrate in foods by capillary ion electrophoresis
Marshall, P. A., & Trenerry, V. C. (1996) · Food Chemistry · doi:10.1016/0308-8146(96)00002-7 · Cited by 43
Cornée, J., Lairon, D., Velema, J., Guyader, M., & Berthézène, P. (1992) · Sciences des Aliments · Cited by 34
Chen, C.-S., Pignatelli, B., MALAVEILLE, C., Bouvier, G., Shuker, D. E. G., Hautefeuille, A. H., Zhang, R. F., & Bartsch, H. (1992) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(92)90050-c · Cited by 30
A survey of nitrite concentrations in retail fresh vegetables
Hunt, J. W., & Turner, M. K. (1994) · Food Additives & Contaminants · doi:10.1080/02652039409374231 · Cited by 27
Occurrence of Nitrate, Nitrite and Volatile Nitrosamines in Certain Feedstuffs and Animal Products
Ologhobo, A. D., Adegede, H. I., & Maduagiwu, E. N. (1996) · Nutrition and Health · doi:10.1177/026010609601100203 · Cited by 16
van Vliet, J. J. H., Vaessen, H. A. M. G., van den Burg, G., & Schothorst, R. C. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)04688-0 · Cited by 14
Nitrate Extraction during Blanching of Spinach
Gaiser, M., Rathjen, A., & Spieß, W. E. L. (1997) · LWT · doi:10.1006/fstl.1996.0200 · Cited by 14
Cashel, K. M., & Greenfield, H. (1995) · Journal of Food Composition and Analysis · doi:10.1006/jfca.1995.1007 · Cited by 6
A method for measuring nitrite in fresh vegetables
Hunt, J. W. (1994) · Food Additives & Contaminants · doi:10.1080/02652039409374230 · Cited by 6
O XVI B.2 Helicobacter pylori and gastric cancer — A case study in molecular epidemiology
Forman, D., & Shuker, D. E. G. (1997) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)83173-9 · Cited by 3
Research works printed but not linked: 3
- Lichon, 1996, ‘Sample preparation’, Vol. 1
- Weisburger, J. H. (1981). ‘N-nitroso compounds: Diet and cancer trends’, in N-nitroso Compounds. In R.A. Scanlan, S.R. Tannenbaum (Eds.), American chemical society symposium series 174, United States.
- Zanardi, 2002, Comparative study on nitrite and nitrate ions determination, Annali Facolta di medicina veterinaria Di Parma, 22, 79
Cited by
Sorted by citations
Liquid Chromatography Analysis of Common Nutritional Components, in Feed and Food
Cortés-Herrera, C., Artavia, G., Leiva, A., & Granados-Chinchilla, F. (2018) · Foods · doi:10.3390/foods8010001 · Cited by 275
Flores, M., & Toldrá, F. (2020) · Meat Science · doi:10.1016/j.meatsci.2020.108272 · Cited by 231
Bahadoran, Z., Mirmiran, P., Jeddi, S., Azizi, F., Ghasemi, A., & Hadaegh, F. (2016) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2016.06.006 · Cited by 228
Nitrite and nitrate in meat processing: Functions and alternatives
Zhang, Y., Zhang, Y., Jia, J., Peng, H., Qian, Q., Pan, Z., & Liu, D. (2023) · Current Research in Food Science · doi:10.1016/j.crfs.2023.100470 · Cited by 210
Reduction of Nitrite in Meat Products through the Application of Various Plant-Based Ingredients
Ferysiuk, K., & Wójciak, K. M. (2020) · Antioxidants · doi:10.3390/antiox9080711 · Cited by 175
Metadata
- Authors
- Hsu, J., Arcot, J., & Alice Lee, N.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Arcot, Jayashree
- ORCID
- Arcot, Jayashree
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 115
- Issue
- 1
- Pages
- 334-339
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2003363212
- Cited by
- 150
- References
- 32
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 17 · 2020: 15 · 2019: 8 · 2018: 13 · 2017: 18 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 9
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Physical Sciences › Chemistry › Analytical Chemistry › Dye analysis and toxicity
- Keywords
- dietary nitrate, dietary nitrite, cured meat, leafy vegetables, N-nitroso compounds, nitrate determination, nitrite determination, HPLC-UV method, food standards compliance, Australian consumers
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