Chemical analysis, antioxidant, antiinflammatory and anticholinesterase activities of Origanum ehrenbergii Boiss and Origanum syriacum L. essential oils
Abstract
The essential oils of Origanum ehrenbergii and O. syriacum collected in Lebanon were analysed by GC and GC-MS and evaluated for their anticholinesterase, NO production inhibitory activities, and antioxidant properties. O. ehrenbergi essential oil was characterised by the presence of 37 components, representing 94.9% of the total oil of which thymol (19%) and p-cymene (16.1%) were the main abundant compounds. Thirty-six compounds characterised the O. syriacum essential oil, representing 90.6% of the total oil. The most abundant components were thymol (24.7%) and carvacrol (17.6%). O. ehrenbergii demonstrated interesting scavenging effects on DPPH with an IC₅₀ value of 0.99μg/ml. In addition, both O. ehrenbergii and O. syriacum oils inhibited oxidation of linoleic acid after 30min of incubation, as well as after 60min of incubation with IC₅₀ values of 42.1 and 33.6μg/ml, and 46.9 and 58.9μg/ml, respectively. Interestingly, O. ehrenbergii oil inhibited NO production in the murine monocytic macrophage cell line RAW 264.7 with an IC₅₀ value of 66.4μg/ml. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition was assessed by modifications of the Ellman's method. O. ehrenbergii exhibited a strong activity against both cholinesterases with IC₅₀ values of 0.3μg/ml. The data suggest that O. ehrenbergii and O. syriacum oils could be used as a valuable new flavour with functional properties for food or nutriceutical products with particular relevance to supplements for the elderly.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Origanum ehrenbergii oil induces a significant inhibitory effect on LPS-induced NO production in RAW 264.7 cells, whereas Origanum syriacum oil does not show such ability.
“Incubation of RAW 264.7 cells with Origanum ehrenbergii Boiss. oil, in which thymol and p-cymene predominated, induced a significant inhibitory effect on the LPS-induced NO production. Origanum syriacum L. predominatly composed by carvacrol and thymol did not show such ability [139].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [139]
The citation lists haven’t been fetched yet
References 31 · Cited by 196
- Authors
- Loizzo, M. R., Menichini, F., Conforti, F., Tundis, R., Bonesi, M., Saab, A. M., Statti, G. A., Cindio, B. D., Houghton, P. J., Menichini, F., & Frega, N. G.
- Affiliations
- Marche Polytechnic University (IT)
- University of Calabria (IT)
- Lebanese University (LB)
- King's College London (GB)
- Corresponding author
- Loizzo, Monica R.
- ORCID
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 117
- Issue
- 1
- Pages
- 174-180
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2082213920
- Cited by
- 196
- References
- 31
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 17 · 2023: 12 · 2022: 16 · 2021: 15 · 2020: 17 · 2019: 15 · 2018: 8 · 2017: 10 · 2016: 8 · 2015: 17 · 2014: 6 · 2013: 9 · 2012: 11
- FWCI
- 19.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- Origanum syriacum, essential oils, thymol, carvacrol, p-cymene, antioxidant activity, anti-inflammatory activity, anticholinesterase activity, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, nitric oxide inhibition, linoleic acid oxidation, DPPH radical scavenging, RAW 264.7 macrophages, nutraceuticals, functional food ingredients
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
