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Growth inhibition and antioxidative status induced by selenium-enriched broccoli extract and selenocompounds in DNA mismatch repair-deficient human colon cancer cells
Abstract
The effects of enzymatic-digested Se-enriched broccoli extracts (SeB) and selenocompounds on growth and antioxidative status in human colon cancer cells was investigated in this study. HCT116 and HCT116+Chr.3 cells were treated with selenocompounds (sodium selenite, sodium selenate, Se-Met, MeSeCys) or SeB [high-Se (H-SeB) or low-Se (L-SeB)]. The cytotoxicity induced by selenocompounds in HCT116 cells was not associated with cellular H2O2 level, while the differential cytotoxicity observed by sodium selenite between HCT116 and HCT116+Chr.3 cell lines was related to cellular H2O2 production with the change in antioxidative enzyme activity, and the restoration of chromosome 3. H-SeB was found to reduce the cellular H2O2 content in HCT116+Chr.3 cells. The results in this study indicate that regardless of Se content, the cytotoxicity in HCT116 cells of both SeB forms appeared to be H2O2-independent, whereas the cytotoxicity in HCT116+Chr.3 of either SeB form appeared to be H2O2-dependent with an increase in antioxidative ability for H-SeB.
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Organic forms of selenium available in biofortified products are the preferred choice for long-term population-wide selenium supplementation because they may have additional health value under selenium-deficient conditions.
“The organic forms of Se available in biofortified products are the preferred choice for long-term population-wide Se supplementation strategies [24] as they may have additional health value under Se-deficient conditions [25].”
From Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review (2015) · cites this paper as [25]
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Research works printed but not linked: 30
- Brennan, 2011, Selenium content in blood fractions and liver of beef heifers is greater with a mix of inorganic/organic or organic versus inorganic supplemental selenium but the time required for maximal assimilation is tissue-specific, Biological Trace Element Research, 144, 504, 10.1007/s12011-011-9069-y · DOI
- Brierley, 2012, Oxidative stress and the DNA mismatch repair pathway, Antioxidants and Redox Signaling
- Chang, 2003, Effect of H2O2 on cell cycle and survival in DNA mismatch repair-deficient and -proficient cell lines, Cancer Letters, 195, 243, 10.1016/S0304-3835(03)00145-9 · DOI
- Clark, 1996, Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial., Journal of the American Medical Association, 276, 1957, 10.1001/jama.1996.03540240035027 · DOI
- Clark, 1998, Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial, British Journal of Urology, 81, 730, 10.1046/j.1464-410x.1998.00630.x · DOI
- De Angelis, 2004, Comparison of gene expression in HCT116 treatment derivative generated by two different 5-fluorouracil exposure protocols, Molecular Cancer, 26, 11, 10.1186/1476-4598-3-11 · DOI
- Duffield-Lillico, 2002, Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the nutritional prevention of cancer trial, Cancer Epidemiology Biomarkers and Prevention, 11, 630
- Finley, 2003, Reduction of cancer risk by consumption of selenium-enriched plants: enrichment of broccoli with selenium increases the anticarcinogenic properties of broccoli, Journal of Medicinal Food, 6, 19, 10.1089/109662003765184714 · DOI
- Finley, 2001, Selenium (Se) from high-selenium broccoli is utilized differently than selenite, selenate and selenomethionine, but is more effective in inhibiting colon carcinogenesis, BioFactors, 14, 191, 10.1002/biof.5520140124 · DOI
- Finley, 2000, Selenium from high selenium broccoli protects rats from colon cancer, Journal of Nutrition, 130, 2384, 10.1093/jn/130.9.2384 · DOI
- Finley, 2001, Cancer-protective properties of high-selenium broccoli, Journal of Agricultural and Food Chemistry, 49, 2679, 10.1021/jf0014821 · DOI
- Finley, 2005, Selenium enrichment of broccoli: interactions between selenium and secondary plant compounds, Journal of Nutrition, 135, 1236, 10.1093/jn/135.5.1236 · DOI
- Gladyshev, 1999, Selenocysteine-containing proteins in mammals, Journal of Biomedical Science, 6, 151, 10.1007/BF02255899 · DOI
- Guo, 2012, Selenium and cardiovascular surgery: an overview, Current Drug Safety, 7, 321, 10.2174/1574886311207040321 · DOI
- Ip, 1998, Lessons from basic research in selenium and cancer prevention, Journal of Nutrition, 128, 1845, 10.1093/jn/128.11.1845 · DOI
- Kirsh, 2007, Prospective study of fruit and vegetable intake and risk of prostate cancer, Journal of National Cancer Institute, 99, 1200, 10.1093/jnci/djm065 · DOI
- Koi, 1994, Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N’-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation, Cancer Research, 54, 4308
- Lee, 2004, Detection of an involvement of the human mismatch repair genes hMLH1 and hMSH2 in nucleotide excision repair is dependent on UVC fluence the cells, Cancer Research, 64, 3865, 10.1158/0008-5472.CAN-03-3193 · DOI
- Mosmann, 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, Journal of Immunological Methods, 65, 55, 10.1016/0022-1759(83)90303-4 · DOI · Paper page
- Nève, 2002, Selenium as a ‘nutraceutical’: how to conciliate physiological and supra-nutritional effects for an essential trace element, Current Opinion in Clinical Nutrition and Metabolic Care, 5, 659, 10.1097/00075197-200211000-00008 · DOI
- Paglia, 1967, Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase, The Journal of Laboratory and Clinical Medicine, 70, 158
- Planck, 2003, Microsatellite instability and expression of MLH1 and MSH2 in carcinomas of the small intestine, Cancer, 97, 1774, 10.1002/cncr.11197 · DOI
- Robinson, 2003, Enhanced radiosensitization with gemcitabine in mismatch repair-deficient HCT 116 cells, Cancer Research, 63, 6935
- Tapiero, 2003, The antioxidant role of selenium and seleno-compounds, Biomedicine and Pharmacotherapy, 57, 134, 10.1016/S0753-3322(03)00035-0 · DOI
- Terry, 2000, Selenium in higher plants, Annual Review of Plant Physiology, 51, 401, 10.1146/annurev.arplant.51.1.401 · DOI · Paper page
- Vetrani, 2012, Nutrition and oxidative stress: a systematic review of human studies, International Journal of Food Sciences and Nutrition
- Whanger, 2002, Selenocompounds in plants and animals and their biological significance, Journal of the American College of Nutrition, 21, 223, 10.1080/07315724.2002.10719214 · DOI
- Yeh, 2002, Differential influences of various arsenic compounds on glutathione redox status and antioxidative enzymes in porcine endothelial cells, Cellular and Molecular Life Sciences, 59, 1972, 10.1007/PL00012519 · DOI
- Yeh, 2006, Mechanism for proliferation inhibition by various selenium compounds and selenium-enriched broccoli extract in rat glial cells, BioMetals, 19, 611, 10.1007/s10534-006-0007-y · DOI
- Zhou, 2010, Think outside the box: selenium volatilization altered by a broccoli gene in the ubiquinone biosynthetic pathway, Plant Signaling and Behavior, 5, 76, 10.4161/psb.5.1.10235 · DOI
Cited by
Sorted by citations
Selenium Cycling Across Soil-Plant-Atmosphere Interfaces: A Critical Review
Winkel, L., Vriens, B., Jones, G., Schneider, L., Pilon-Smits, E., & Bañuelos, G. (2015) · Nutrients · doi:10.3390/nu7064199 · Cited by 476
Bañuelos, G. S., Arroyo, I., Pickering, I. J., Yang, S. I., & Freeman, J. L. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2014.06.071 · Cited by 184
Metadata
- Authors
- Tsai, C.-F., Ou, B.-R., Liang, Y.-C., & Yeh, J.-Y.
- Affiliations
- Asia University (TW)
- Tunghai University (TW)
- Agricultural Biotechnology Research Center, Academia Sinica (TW)
- ORCID
- Liang, Yu-Chuan
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 139
- Issue
- 1-4
- Pages
- 267-273
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2022298189
- Cited by
- 20
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 5 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 2
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Asia University
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Physical Sciences › Chemistry › Organic Chemistry › Organoselenium and organotellurium chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- selenocompounds, sodium selenite, sodium selenate, selenomethionine, methylselenocysteine, mismatch repair deficiency, colon cancer cells, HCT116 cells, hydrogen peroxide, antioxidant enzymes, selenium bioavailability, chromosome 3
- MeSH terms
- Antioxidants, Brassica, Colonic Neoplasms, Humans, Hydrogen Peroxide, Plant Extracts, Selenium, Selenium Compounds, HCT116 Cells, Cell Proliferation, DNA Mismatch Repair
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