The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Improving the controlled delivery formulations of caffeine in alginate hydrogel beads combined with pectin, carrageenan, chitosan and psyllium
Abstract
Alginate-based blends consisting of carrageenan, pectin, chitosan or psyllium husk powder were prepared for assessment of the best formulation aimed at encapsulation of caffeine. Alginate-pectin blend exhibited the lowest viscosity and provided the smallest beads. Alginate-psyllium husk blend was characterised with higher viscosity, yielding the largest bead size and the highest caffeine encapsulation efficiency (83.6%). The release kinetics of caffeine indicated that the porosity of alginate hydrogel was not reduced sufficiently to retard the diffusion of caffeine from the beads. Chitosan coated alginate beads provided the most retarded release of caffeine in water. Morphological characteristics of beads encapsulating caffeine were adversely affected by freeze drying. Bitterness intensity of caffeine-containing beads in water was the lowest for alginate-psyllium beads and chitosan coated alginate beads. Higher sodium alginate concentration (3%) for production of hydrogel beads in combination with psyllium or chitosan coating would present the most favourable carrier systems for immobilization of caffeine.
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“Chitosan, alginate, hyaluronic acid, dextran, xanthan, and gum-tragacanth are some examples of pH-sensitive biopolymers (Belscak-Cvitanovic et al., 2015; Garshasbi et al., 2023).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Belscak-Cvitanovic et al., 2015
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Cites
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Research works printed but not linked: 3
- Krishnamoorthy, 2013, Chitosan coated alginate-carrageenan particulate systems for sustained release of naproxen, International Journal of Pharmaceuticals and Health Care, 01, 96
- Normah, 2013, Bitterness of green mussel (Perna viridis) hydrolysate as influenced by the degree of hydrolysis, International Food Research Journal, 20, 2261
- Sriamornsak, P. (1996). The utilization of pectin for the development of sustained release theophylline pellets (M.S. thesis). Thailand: Mahidol University.
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pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery.
Vegad, U., Patel, M., Khunt, D., Zupančič, O., Chauhan, S., & Paudel, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1270364 · Cited by 85
“Chitosan, alginate, hyaluronic acid, dextran, xanthan, and gumtragacanth are some examples of pH-sensitive biopolymers (Belscak-Cvitanovic et al., 2015; Garshasbi et al., 2023).”
BackgroundMumcu, A., Temiz, A., & Denkbas, E. B. (2026) · Biotech Studies · doi:10.38042/biotechstudies.1849883
Metadata
- Authors
- Belščak-Cvitanović, A., Komes, D., Karlović, S., Djaković, S., Špoljarić, I., Mršić, G., & Ježek, D.
- Affiliations
- University of Zagreb (HR)
- MUP Centar za forenzična ispitivanja, istraživanja i vještačenja "Ivan Vučetić" (HR)
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 167
- Pages
- 378-386
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W1981347732
- Cited by
- 244
- References
- 35
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 26 · 2023: 35 · 2022: 31 · 2021: 30 · 2020: 22 · 2019: 14 · 2018: 17 · 2017: 6 · 2016: 14 · 2015: 10
- FWCI
- 14.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science, Education and Sports, Republic of Croatia
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Microencapsulation and Drying Processes
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Keywords
- caffeine, controlled release, alginate beads, pectin, carrageenan, chitosan coating, psyllium husk, encapsulation efficiency, release kinetics, freeze-drying, bitterness, sodium alginate concentration
- MeSH terms
- Alginates, Caffeine, Carrageenan, Chemistry, Pharmaceutical, Hexuronic Acids, Pectins, Psyllium, Hydrogel, Polyethylene Glycol Dimethacrylate, Glucuronic Acid, Chitosan
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