The DOI matches its Crossref record; 136 of the 140 references it cites were found in a registry or an index.
Biological and pharmacological aspects of tannins and potential biotechnological applications
Open accessAbstract
Secondary metabolites are divided into three classes: phenolic, terpenoid, and nitrogenous compounds. Phenolic compounds are also known as polyphenols and include tannins, classified as hydrolysable or condensed. Herein, we explored tannins for their ROS reduction characteristics and role in homeostasis. These activities are associated with the numbers and degree of polymerisation of reactive hydroxyl groups present in the phenolic rings of tannins. These characteristics are associated with anti-inflammatory, anti-aging, and anti-proliferative health benefits. Tannins can reduce the risk of cancer and neurodegenerative diseases, such as cardiovascular diseases and Alzheimer's, respectively. These biomolecules may be used as nutraceuticals to maintain good gut microbiota. Industrial applications include providing durability to leather, anti-corrosive properties to metals, and substrates for 3D printing and in bio-based foam manufacture. This review updates regarding tannin-based research and highlights its biological and pharmacological relevance and potential applications.
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“Tannic acid (TA), a natural polyphenolic compound, has attracted significant attention in the biomedical field due to its potent antioxidant and anti-inflammatory properties24,25, indicating its potential for application in the treatment of osteoporotic fractures.”
From Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture (2026) · cites this paper as [25]
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Cites
2 retracted
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RetractedKang, J. H., Boumenna, T., Stein, J. D., Khawaja, A. P., ROSNER, B. A., Wiggs, J. L., & Pasquale, L. R. (2020) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2020.0027 · Cited by 3
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Tannins for food preservation and human health: A review of current knowledge
Özoğul, Y., Uçar, Y., Tadesse, E. E., Rathod, N. B., Kulawik, P., Trif, M., Esatbeyoglu, T., & Özoğul, F. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.100738 · Cited by 87
Kim, Y., Lim, J., & Oh, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117277 · Cited by 67
Brezo-Borjan, T., Švarc‐Gajić, J., Morais, S., Delerue-Matos, C. M., Rodrigues, F., Lončarević, I. S., & Pajin, B. S. (2023) · Processes · doi:10.3390/pr11061766 · Cited by 49
HÜRKUL, M. M., Çetinkaya, A., Yayla, Ş., & Özkan, S. A. (2024) · Journal of Chromatography Open · doi:10.1016/j.jcoa.2024.100131 · Cited by 44
Wang, C., Zhang, H., Wang, X., Wang, X., Li, X., Li, C., Wang, Y., & Min, Z. (2024) · Molecules · doi:10.3390/molecules29235547 · Cited by 37
Metadata
- Authors
- Melo, L. F. M. D., Aquino-Martins, V. G. D. Q., Silva, A. P. D., Oliveira Rocha, H. A., & Scortecci, K. C.
- Affiliations
- Universidade Federal do Rio Grande do Norte (BR)
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 414
- Pages
- 135645
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W4319320211
- Semantic Scholar
- b37f05ad7ca85ab9bf6d1e0ebc562fb201cca365
- Cited by
- 137
- References
- 140
- Citations by year
- 2026: 34 · 2025: 45 · 2024: 43 · 2023: 15
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 235 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Tannin, Tannase and Anticancer Activities
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Lignin and Wood Chemistry
- Keywords
- tannins, hydrolysable tannins, proanthocyanidins, polyphenols, reactive oxygen species scavenging, antioxidant activity, anti-inflammatory activity, anti-aging, antiproliferative activity, cancer prevention, neurodegenerative diseases, cardiovascular disease, nutraceuticals, gut microbiota, leather tanning, corrosion protection, 3D printing, bio-based foams
- MeSH terms
- Phenols, Plant Extracts, Tannins, Dietary Supplements, Polyphenols
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