Cited by 138Tannin, Tannase and Anticancer ActivitiesPhytochemicals and Antioxidant ActivitiesLignin and Wood Chemistry

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Biological and pharmacological aspects of tannins and potential biotechnological applications

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Melo, Luciana Fentanes Moura de, Aquino-Martins, Verônica Giuliani de Queiroz, Silva, Ariana Pereira da, Oliveira Rocha, Hugo Alexandre, Scortecci, Katia Castanho·2023·Food Chemistry

DOI 10.1016/j.foodchem.2023.135645

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Abstract

Secondary metabolites are divided into three classes: phenolic, terpenoid, and nitrogenous compounds. Phenolic compounds are also known as polyphenols and include tannins, classified as hydrolysable or condensed. Herein, we explored tannins for their ROS reduction characteristics and role in homeostasis. These activities are associated with the numbers and degree of polymerisation of reactive hydroxyl groups present in the phenolic rings of tannins. These characteristics are associated with anti-inflammatory, anti-aging, and anti-proliferative health benefits. Tannins can reduce the risk of cancer and neurodegenerative diseases, such as cardiovascular diseases and Alzheimer's, respectively. These biomolecules may be used as nutraceuticals to maintain good gut microbiota. Industrial applications include providing durability to leather, anti-corrosive properties to metals, and substrates for 3D printing and in bio-based foam manufacture. This review updates regarding tannin-based research and highlights its biological and pharmacological relevance and potential applications.

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Authors: Melo, L. F. M. D., Aquino-Martins, V. G. D. Q., Silva, A. P. D., Oliveira Rocha, H. A., & Scortecci, K. C.
Affiliations: Universidade Federal do Rio Grande do Norte (BR)
ORCID: Aquino-Martins, Verônica Giuliani de Queiroz
Silva, Ariana Pereira da
Scortecci, Katia Castanho
Venue: Food Chemistry
Publisher: Elsevier BV
Published: 2023-07
Volume: 414
Pages: 135645
ISSN: 0308-8146 (ISSN-L)
DOI: 10.1016/j.foodchem.2023.135645
OpenAlex: W4319320211
Semantic Scholar: b37f05ad7ca85ab9bf6d1e0ebc562fb201cca365
Cited by: 137
References: 140
Citations by year: 2026: 34 · 2025: 45 · 2024: 43 · 2023: 15
FWCI: 2.65
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 235 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Food Chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics: Physical Sciences › Chemistry › Organic Chemistry › Tannin, Tannase and Anticancer Activities
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Lignin and Wood Chemistry
Keywords: tannins, hydrolysable tannins, proanthocyanidins, polyphenols, reactive oxygen species scavenging, antioxidant activity, anti-inflammatory activity, anti-aging, antiproliferative activity, cancer prevention, neurodegenerative diseases, cardiovascular disease, nutraceuticals, gut microbiota, leather tanning, corrosion protection, 3D printing, bio-based foams
MeSH terms: Phenols, Plant Extracts, Tannins, Dietary Supplements, Polyphenols

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Biological and pharmacological aspects of tannins and potential biotechnological applications

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