Interactions between Ginkgo biloba L. and Scutellaria baicalensis Georgi in multicomponent mixtures towards cholinesterase inhibition and ROS scavenging
Abstract
This study gives new insights to understand the type of interactions between Ginkgo biloba L. and Scutellaria baicalensis Georgi, two Chinese medicinal plants with well documented neuroprotective effects, on three targets in Alzheimer's disease (AD): acetylcholinesterase (AChE) and butyrylcholnesterase (BuChE) inhibition and hydrogen peroxide scavenging. Individual samples, binary mixtures with different proportions of both plant species, and also a commercial multicomponent combination containing both plants together with unroasted Coffea arabica L. and quercetin-3-O-rutinoside were used to perform this in vitro evaluation. Sample phenolic profiles were also determined by HPLC-DAD, showing the presence of several flavonoid glycosides, phenolic acids and a methylxanthine. In order to investigate the possible synergism/antagonism interaction, data obtained were analyzed by CompuSyn software. The results showed that G. biloba and S. baicalensis alone display better activities than in mixtures, most of the interactions exhibiting different degrees of antagonism. A slight synergism interaction was only observed for the commercial multicomponent mixture tested against H 2 O 2. Further analysis was carried out to understand which compounds could be responsible for the antagonistic interaction. Seventeen single pure compounds present in all extracts were tested against AChE inhibition, most of them displaying weak or no activity. Only caffeine had a remarkable activity. Five different binary and quaternary mixture compositions were design to deepen the interaction between these compounds, revealing mainly phenolic acid-flavonoid, flavonoid-flavonoid and methylxanthine-flavonoid-phenolic acid antagonistic interactions. These results clearly show that, for the targets evaluated, there is no potentiation of the neuroprotective effect by combining S. baicalensis and G. biloba extracts.
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Decoctions from Ginkgo biloba leaves and Scutellaria baicalensis roots displayed moderate acetylcholinesterase and butyrylcholinesterase inhibition and strong scavenging activity against hydrogen peroxide.
“Therefore, in a previous study, we have demonstrated that the decoctions prepared from the leaves of G. biloba and from the roots of S. baicalensis displayed moderate acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition as well as a strong scavenging activity against hydrogen peroxide, a ROS (Delerue et al., 2021).”
From Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease (2022) · cites this paper as Delerue et al., 2021
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Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease
Fernandes, F., Barroso, M. F., De Simone, A., Emriková, E., Dias-Teixeira, M., Pereira, J. P., Chlebek, J., Fernandes, V. C., Rodrigues, F., Andrisano, V., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115107 · Cited by 45 · see citing works
Self-citation
- Authors
- Delerue, T., Fátima Barroso, M., Dias-Teixeira, M., Figueiredo-González, M., Delerue-Matos, C., & Grosso, C.
- Affiliations
- Rede de Química e Tecnologia (PT)
- Corresponding author
- Grosso, Clara
- Venue
- Food Research International
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 140
- Pages
- 109857
- ISSN
- 0963-9969 (ISSN-L)
- OpenAlex
- W3097416047
- Cited by
- 24
- References
- 96
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 1
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Research International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia
- Xunta de Galicia
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Ginkgo biloba, Scutellaria baicalensis, plant extract combination, synergistic and antagonistic effects, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, hydrogen peroxide scavenging, antioxidant activity, Alzheimer's disease, neuroprotection, phenolic acids, flavonoid glycosides, caffeine, rutin, Coffea arabica
- MeSH terms
- Cholinesterases, Hydrogen Peroxide, Plant Extracts, Reactive Oxygen Species, Ginkgo biloba, Scutellaria baicalensis
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