The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Cytochrome c/cardiolipin relations in mitochondria: a kiss of death
Open accessAbstract
Recently, phospholipid peroxidation products gained a reputation as key regulatory molecules and participants in oxidative signaling pathways. During apoptosis, a mitochondria-specific phospholipid, cardiolipin (CL), interacts with cytochrome c (cyt c) to form a peroxidase complex that catalyzes CL oxidation; this process plays a pivotal role in the mitochondrial stage of the execution of the cell death program. This review is focused on redox mechanisms and essential structural features of cyt c's conversion into a CL-specific peroxidase that represent an interesting and maybe still unique example of a functionally significant ligand change in hemoproteins. Furthermore, specific characteristics of CL in mitochondria – its asymmetric trans-membrane distribution and mechanisms of collapse, regulation of its synthesis, remodeling and fatty acid composition – are given significant consideration. Finally, new concepts in drug discovery based on the design of mitochondria-targeted inhibitors of cyt c/CL peroxidase and CL peroxidation with anti-apoptotic effects are presented.
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Cites
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Cited by
Hanschmann, E.-M., Godoy, J. R., Berndt, C., Hudemann, C., & Lillig, C. H. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4599 · Cited by 677
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Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy
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Metadata
- Authors
- Kagan, V. E., Bayır, H. A., Belikova, N. A., Kapralov, O., Tyurina, Y. Y., Tyurin, V. A., Jiang, J., Stoyanovsky, D. A., Wipf, P., Kochanek, P. M., Greenberger, J. S., Pitt, B., Shvedova, A. A., & Borisenko, G.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 46
- Issue
- 11
- Pages
- 1439-1453
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2054739775
- Cited by
- 444
- References
- 152
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Kagan, V. E., Bayır, H. A., Belikova, N. A., Kapralov, O., Tyurina, Y. Y., Tyurin, V. A., Jiang, J., Stoyanovsky, D. A., Wipf, P., Kochanek, P. M., Greenberger, J. S., Pitt, B., Shvedova, A. A., & Borisenko, G. (2009). Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2009.03.004
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