The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.
Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling
Abstract
Prxs (peroxiredoxins) are a family of proteins that are extremely effective at scavenging peroxides. The Prxs exhibit a number of intriguing properties that distinguish them from conventional antioxidants, including a susceptibility to inactivation by hyperoxidation in the presence of excess peroxide and the ability to form complex oligomeric structures. These properties, combined with a high cellular abundance and reactivity with hydrogen peroxide, have led to speculation that the Prxs function as redox sensors that transmit signals as part of the cellular response to oxidative stress. Multicellular organisms express several different Prxs that can be categorized by their subcellular distribution. In mammals, Prx 3 and Prx 5 are targeted to the mitochondrial matrix. Mitochondria are a major source of hydrogen peroxide, and this oxidant is implicated in the damage associated with aging and a number of pathologies. Hydrogen peroxide can also act as a second messenger, and is linked with signalling events in mitochondria, including the induction of apoptosis. A simple kinetic competition analysis estimates that Prx 3 will be the target for up to 90% of hydrogen peroxide generated in the matrix. Therefore, mitochondrial Prxs have the potential to play a major role in mitochondrial redox signalling, but the extent of this role and the mechanisms involved are currently unclear.
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Metadata
- Authors
- Cox, A. G., Winterbourn, C. C., & Hampton, M. B.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2009-12-23
- Volume
- 425
- Issue
- 2
- Pages
- 313-325
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2019560775
- Cited by
- 532
- References
- 191
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- closed
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