The DOI matches its Crossref record; 313 of the 313 references it cites were found in a registry or an index.
Oxidative stress and glutathione in TGF-β-mediated fibrogenesis
Open accessAbstract
Transforming growth factor beta (TGF-β) is the most potent and ubiquitous profibrogenic cytokine and its expression is increased in almost all the fibrotic diseases and in experimental fibrosis models. TGF-β increases ROS production and decreases the concentration of glutathione (GSH), the most abundant intracellular free thiol and an important antioxidant, in various types of cells, which mediates many of TGF-β’s fibrogenic effects. A decreased GSH concentration is also observed in human fibrotic diseases and in experimental fibrosis models. Although the biological significance of GSH depletion in the development of fibrosis remains obscure, GSH and N-acetylcysteine (NAC), a precursor of GSH, have been used in clinics for the treatment of fibrotic diseases. This review summarizes recent findings in the field to address the potential mechanism whereby oxidative stress mediates TGF-β’s fibrogenesis and the potential therapeutic values of antioxidant treatment in fibrotic diseases.
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1 retracted
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Kirkham, P. A., & Barnes, P. J. (2013) · Chest · doi:10.1378/chest.12-2664 · Cited by 685
Antifibrotic activities of pirfenidone in animal models
Schaefer, C. J., Ruhrmund, D. W., Pan, L., Seiwert, S. D., & Kossen, K. (2011) · European Respiratory Review · doi:10.1183/09059180.00001111 · Cited by 454
The Role of AGE/RAGE Signaling in Diabetes-Mediated Vascular Calcification
Kay, A. M., Simpson, C. L., & Stewart, J. A. (2016) · Journal of Diabetes Research · doi:10.1155/2016/6809703 · Cited by 346
Pekovic-Vaughan, V., Gibbs, J., Yoshitane, H., Yang, N., Pathiranage, D., Guo, B., Sagami, A., Taguchi, K., Bechtold, D., Loudon, A., et al. (2014) · Genes & Development · doi:10.1101/gad.237081.113 · Cited by 323
Identification of Structural Elements in Nox1 and Nox4 Controlling Localization and Activity
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Metadata
- Authors
- Liu, R.-M., & Gaston Pravia, K. A.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 48
- Issue
- 1
- Pages
- 1-15
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2086378628
- Cited by
- 469
- References
- 313
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
