Cited by 407Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 185 of the 188 references it cites were found in a registry or an index.

Neuroprotective strategies involving ROS in Alzheimer disease

Open access

Dumont, Magali, Beal, M. Flint·2011·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2010.11.026PMC PMC3070183

Open this paper in CoChat — free account

Abstract

Alzheimer disease (AD) is a neurodegenerative disorder in which oxidative stress is a key hallmark. It occurs early in disease pathogenesis and can exacerbate its progression. Several causes of oxidative stress have been determined over the years. First, mitochondria play an important role in the generation and accumulation of free radicals. In addition to mitochondria, inflammation can also induce oxidative damage, especially via microglia, and microglia are also important for Aβ clearance. In AD, both mitochondrial function and inflammatory response are affected, leading to increased ROS formation and oxidative damage to lipid, proteins, and nucleic acids. Some other sources have also been identified. From these findings, various neuroprotective strategies against ROS-mediated damages have been elaborated in AD research. This review recapitulates some of the major strategies used to prevent oxidative stress and disease progression. Outcomes from in vitro and in vivo studies using models of AD are encouraging. However, only a few clinical trials have provided positive results in terms of slowing down cognitive decline. Nonetheless, there is still hope for improved compounds that would better target pathways implicated in ROS production. In fact, facilitating the endogenous antioxidant system by modulating transcription has great promise for AD therapy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2010.11.026

Cites

185 of 185 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype
Wenz, T., Diaz, F., Spiegelman, B. M., & Moraes, C. T. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.006 · Cited by 297
Retracted
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Self-citation
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
Nguyen, T., Nioi, P., & Pickett, C. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r900010200 · Cited by 2,655
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
Moi, P., Chan, K., Asunis, I., Cao, A., & Kan, Y. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9926 · Cited by 1,607
Vitamin E, antioxidant and nothing more
Traber, M. G., & Atkinson, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.024 · Cited by 1,547
Microglia in neurodegenerative disease
Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543

Show all 188 references

Research works printed but not linked: 1

2010, Acetyl-L-carnitine, Monogr. Altern. Med. Rev., 15, 76

Sorted by citations

Items 201–300 of 407

Palm Fruit Bioactives modulate human astrocyte activity in vitro altering the cytokine secretome reducing levels of TNFα, RANTES and IP-10
Weinberg, R. P., Koledova, V. V., Schneider, K., Sambandan, T. G., Grayson, A. R., Zeidman, G., Artamonova, A., Sambanthamurthi, R., Fairus, S., Sinskey, A. J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-34763-3 · Cited by 25
Enhanced behavioral response by decreasing brain oxidative stress to 6-hydroxy-l-nicotine in Alzheimer’s disease rat model
Hriţcu, L., Ștefan, M., Brandsch, R., & Mihăşan, M. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.02.014 · Cited by 25
Cognitive-enhancing activities of the polyprenol preparation Ropren® in gonadectomized β-amyloid (25–35) rat model of Alzheimer's disease
Fedotova, J., Soultanov, V., Nikitina, T. V., Roschin, V., Ordyan, N., & Hriţcu, L. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.035 · Cited by 25
Mitochondrial ROS and Apoptosis
El-Osta, H. E., & Circu, M. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-42139-1_1 · Cited by 27
Biogenic silver NPs alleviate LPS-induced neuroinflammation in a human fetal brain-derived cell line: Molecular switch to the M2 phenotype, modulation of TLR4/MyD88 and Nrf2/HO-1 signaling pathways, and molecular docking analysis
Sharma, A., Sanjay, S., Jaiswal, V., Park, M., & Lee, H. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213363 · Cited by 28
Amyloid β oligomers induce interleukin-1β production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner
Taneo, J., Adachi, T., Yoshida, A., Takayasu, K., Takahara, K., & Inaba, K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.02.006 · Cited by 25
Synthesis and SAR study of novel sarsasapogenin derivatives as potent neuroprotective agents and NO production inhibitors
Pan, H., Khang, P. V., Dong, D., Wang, R., & Ma, L. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.11.070 · Cited by 24
The Mitochondrial Targets of Neuroprotective Drug Vinpocetine on Primary Neuron Cultures, Brain Capillary Endothelial Cells, Synaptosomes, and Brain Mitochondria
Sváb, G., Dóczi, J., Gerencser, A. A., Ambrus, A., Gallyas, F., Sümegi, B., & Tretter, L. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02871-9 · Cited by 24
Methyl 3,4-dihydroxybenzoate protects primary cortical neurons against Aβ25-35-induced neurotoxicity through mitochondria pathway
Zhou, X., Zhang, Z., Su, C.-F., Lv, R.-H., Zhou, X., Cai, L., Wang, C.-Y., Li, Y., Zhang, W., & Luo, H. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23235 · Cited by 24
Physcion Mitigates LPS-Induced Neuroinflammation, Oxidative Stress, and Memory Impairments via TLR-4/NF-кB Signaling in Adult Mice
Ahmad, S., Choe, K., Badshah, H., Ahmad, R., Ali, W., Rehman, I. U., Park, T. J., Park, J. S., & Kim, M. O. (2024) · Pharmaceuticals · doi:10.3390/ph17091199 · Cited by 25
Antioxidant Capacity of Thistle (Cirsium japonicum) in Various Drying Methods and their Protection Effect on Neuronal PC12 cells and Caenorhabditis elegans
Jang, M., Kim, K., & Kim, G. (2020) · Antioxidants · doi:10.3390/antiox9030200 · Cited by 23
D ‐ribose‐L ‐cysteine enhances memory task, attenuates oxidative stress and acetyl‐cholinesterase activity in scopolamine amnesic mice
Emokpae, O., Ben‐Azu, B., Ajayi, A. M., & Umukoro, S. (2020) · Drug Development Research · doi:10.1002/ddr.21663 · Cited by 23
Phenolic Compounds from Carissa spinarum Are Characterized by Their Antioxidant, Anti-Inflammatory and Hepatoprotective Activities
Liu, Y., Zhang, Y., Muema, F. W., Kimutai, F., Chen, G., & Guo, M. (2021) · Antioxidants · doi:10.3390/antiox10050652 · Cited by 23
Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease
Zhang, B., Zhao, Y., Guo, K., Tian, H., Cao, W. F., Wang, R. L., Chen, Y., Chen, D., Zheng, H., Gao, B., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10459 · Cited by 23
Lymphocytes of Patients with Alzheimer’s Disease Display Different DNA Damage Repair Kinetics and Expression Profiles of DNA Repair and Stress Response Genes
Leandro, G. D. S., Lôbo, R. R., Oliveira, D. V. N. P., Moriguti, J. C., & Sakamoto‐Hojo, E. T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612380 · Cited by 23
Optimizing the Extraction of Polysaccharides from Bletilla ochracea Schltr. Using Response Surface Methodology (RSM) and Evaluating their Antioxidant Activity
Wang, B., Xu, Y., Chen, L., Zhao, G., Mi, Z., Lv, D., & Niu, J. (2020) · Processes · doi:10.3390/pr8030341 · Cited by 23
Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal
Tsirulnikov, K., Abuladze, N. K., Bragin, A., Faull, K. F., Cascio, D., Damoiseaux, R. D., Schibler, M. J., & Pushkin, A. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.07.002 · Cited by 22
Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells
Kwon, B., Gamache, T., Lee, H., & Querfurth, H. W. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.05.012 · Cited by 23
Hydrogen peroxide enhances LPS-induced nitric oxide production via the expression of interferon beta in BV-2 microglial cells
Eguchi, H., Fujiwara, N., Sakiyama, H., Yoshihara, D., & Suzuki, K. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.047 · Cited by 22
Effects of the Methanolic Extract of Vitellaria paradoxa Stem Bark Against Scopolamine-Induced Cognitive Dysfunction and Oxidative Stress in the Rat Hippocampus
Foyet, H. S., Asongalem, A. E., Eyong, K. O., Cioancă, O., Hăncianu, M., & Hriţcu, L. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0310-7 · Cited by 22
Therapeutic implications of glycogen synthase kinase-3β in Alzheimer’s disease: a novel therapeutic target
Mandlik, D. S., Mandlik, S. K., & Arulmozhi, S. (2022) · International Journal of Neuroscience · doi:10.1080/00207454.2022.2130297 · Cited by 22
A mechanistic study of gold nanoparticles catalysis of O 2 reduction by ascorbate and hydroethidine, investigating reactive oxygen species reactivity
Shcherbakov, V., Denisov, S. A., & Mostafavi, M. (2023) · RSC Advances · doi:10.1039/d3ra00443k · Cited by 21
DNA and BSA damage inhibitory activities, and anti-acetylcholinesterase, anti-porcine α-amylase and antioxidant properties of Dolichos lablab beans
Habib, H. M., Theuri, S. W., Kheadr, E., & Mohamed, F. E. (2016) · Food & Function · doi:10.1039/c6fo01164k · Cited by 21
Palmitic Acid Curcumin Ester Facilitates Protection of Neuroblastoma against Oligomeric Aβ40 Insult
Qi, Z., Wu, M., Fu, Y., Huang, T., Wang, T., Sun, Y., Feng, Z., & Li, C. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485117 · Cited by 21
Virgin Coconut Oil-Induced Neuroprotection in Lipopolysaccharide-Challenged Rats is Mediated, in Part, Through Cholinergic, Anti-Oxidative and Anti-Inflammatory Pathways
Rahim, N. S., Lim, S. M., Mani, V., Hazalin, N. A. M. N., Majeed, A. B. A., & Ramasamy, K. (2021) · Journal of Dietary Supplements · doi:10.1080/19390211.2020.1830223 · Cited by 21
Peroxynitrite and amyloid-β dual-activated near-infrared theranostic probe for oxidative stress monitoring in Alzheimer's disease
Xue, H., Wang, X., Jiang, Q., Ma, J., & Wong, M. S. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.117201 · Cited by 20
Induced Pluripotent Stem Cells Derived from Alzheimer’s Disease Patients: The Promise, the Hope and the Path Ahead
Freude, K., Pires, C., Hyttel, P., & Hall, V. J. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041402 · Cited by 21
Restoration of Mitochondrial Dysfunction in 6-Hydroxydopamine Induced Parkinson’s disease: a Complete Review
Mehan, S., Kaur, G., Dudi, R., Rajput, M., & Kalra, S. (2017) · Open Journal of Parkinson s Disease and Treatment · doi:10.17352/ojpdt.000001 · Cited by 19
The Road from Nanomedicine to Precision Medicine
Rakotoarisoa, M., & Angelova, A. (2020) · doi:10.1201/9781003027010 · Cited by 19
Real Time and Spatiotemporal Quantification of pH and H 2 O 2 Imbalances with a Multiplex Surface-Enhanced Raman Spectroscopy Nanosensor
Xiao, C., Izquierdo‐Roca, V., & Rivera-Gil, P. (2023) · ACS Materials Au · doi:10.1021/acsmaterialsau.2c00069 · Cited by 19
Preclinical Evidence and Possible Mechanisms of Extracts or Compounds from Cistanches for Alzheimer’s Disease
Zhou, X., Xu, M.-B., Jin, T.-Y., Rong, P.-Q., Zheng, G., & Lin, Y. (2019) · Aging and Disease · doi:10.14336/ad.2018.0815-1 · Cited by 19
Reactive Oxygen Species in Neurodegenerative Diseases: Implications in Pathogenesis and Treatment Strategies
Oladele, J. O., Oladiji, A. T., Oladele, O. T., & Oyeleke, O. M. (2021) · Biochemistry · doi:10.5772/intechopen.99976 · Cited by 21
Dibenzo[1,4,5]thiadiazepine: A hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases
González-Muñoz, G. C., Arce, M. P., Pérez, C., Romero, A., Villarroya, M., López, M. G., Conde, S., & Rodrı́guez-Franco, M. I. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.04.075 · Cited by 18
The mechanism of antioxidant activity of IRFI005 as a synthetic hydrophilic analogue of vitamin E
Barzegar, A., Pedersen, J. Z., Incerpi, S., Moosavi‐Movahedi, A. A., & Saso, L. (2011) · Biochimie · doi:10.1016/j.biochi.2011.07.019 · Cited by 17
Ropren® treatment reverses anxiety-like behavior and monoamines levels in gonadectomized rat model of Alzheimer’s disease
Fedotova, J., Soultanov, V., Nikitina, T. V., Roschin, V., Ordyan, N., & Hriţcu, L. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.08.065 · Cited by 17
Myocardial Infarction Predisposes Neurodegenerative Diseases
Zhang, W., & Luo, P. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191225 · Cited by 17
Anorexia and Hypothalamic Degeneration
Nilsson, I. A. K., Lindfors, C., Schalling, M., Hökfelt, T. G. M., & Johansen, J. E. (2013) · Vitamins and hormones · doi:10.1016/b978-0-12-410473-0.00002-7 · Cited by 22
The Plant‐Derived Chalcone 2,2′,5′‐Trihydroxychalcone Provides Neuroprotection against Toll‐Like Receptor 4 Triggered Inflammation in Microglia
Jiwrajka, M., Phillips, A., Butler, M., Rossi, M., & Pocock, J. M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6301712 · Cited by 17
Insights on the Neuromodulatory Propensity of Selaginella (Sanjeevani) and its Potential Pharmacological Applications
., M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660188 · Cited by 17
Dietary Sources, Classification, Biosynthesis, and Mechanism of Action of Flavonoids in Combating Oxidative Stress
Khan, M. S., Khan, S. B., Khan, N., & Khan, A. S. (2024) · Wiley eBooks · doi:10.1002/9781394238071.ch3 · Cited by 18
PBN inhibits a detrimental effect of methamphetamine on brain endothelial cells by alleviating the generation of reactive oxygen species
Hwang, J. S., Cha, E. H., Park, B., Ha, E., & Seo, J. H. (2020) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01284-5 · Cited by 18
Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway
Porter, M. R., Kochi, A., Karty, J. A., Lim, M. H., & Zaleski, J. M. (2014) · Chemical Science · doi:10.1039/c4sc01979b · Cited by 16
Neuroprotective Potential of Guiera senegalensis (Combretaceae) Leaf Hydroethanolic Extract against Cholinergic System Dysfunctions and Oxidative Stress in Scopolamine-Induced Cognitive Impairment in Zebrafish (Danio rerio)
Kamda, J. L. D., Boiangiu, R. Ş., Brinza, I., Djoumessi, L. B. K., Rebe, R. N., Nkwingwa, B. K., Nyayi, S. D. G., Camdi, G. W., Bouvourné, P., Wado, E. K., et al. (2022) · Plants · doi:10.3390/plants11091149 · Cited by 16
Impact of gender on platelet membrane functions of Alzheimer's disease patients
Vignini, A., Giusti, L., Raffaelli, F., Giulietti, A., Salvolini, E., Luzzi, S., Provinciali, L., Mazzanti, L., & Nanetti, L. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.11.015 · Cited by 16
A novel activation-triggered-immobilizing fluorescent probe for real-time tracking of mitochondrial ONOOˉ with high fidelity
Zhu, Y., Liu, C., Rong, X., Zheng, M., Wen, H., Wang, K., 盛文龙, & Zhu, B. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.137774 · Cited by 15
Mitochondrial dysfunction and oxidative stress in Parkinson’s disease: mechanisms, biomarkers, and therapeutic strategies
Ushakiran, P., Haria, J., Rani, R., & Singh, S. K. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2537991 · Cited by 15
Detailed insight into the pathophysiology and the behavioral complications associated with the Parkinson's disease and its medications
Wal, P., Dwivedi, J., Wal, A., Vig, H., & Singh, Y. (2022) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-022-00425-5 · Cited by 15
Neuroprotective effects of Caralluma tuberculata on ameliorating cognitive impairment in a d-galactose-induced mouse model
Khan, M. Z., Atlas, N., & nawaz, W. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.09.055 · Cited by 15
Neuroprotective effects of N-acetyl cysteine on primary hippocampus neurons against hydrogen peroxide-induced injury are mediated via inhibition of mitogen-activated protein kinases signal transduction and antioxidative action
Wu, W., Liu, B., Xie, C., Xia, X., & Zhang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8699 · Cited by 15
Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neuron of the CA1 Hippocampus in Rat Model of Alzheimer's Disease
Eskandary, A., Moazedi, A. A., Nejafzade, H., & Akhond, M. R. (2018) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.9.10.305 · Cited by 15
PEGylated Erythropoietin Protects against Brain Injury in the MCAO-Induced Stroke Model by Blocking NF-κB Activation
Im, J. H., Yeo, I. J., Hwang, C. J., Lee, K. S., & Hong, J. T. (2019) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2019.147 · Cited by 15
Effects of Hypericum scabrum extract on dentate gyrus synaptic plasticity in high fat diet-fed rats
Omidi, G., Rezvani-Kamran, A., Ganji, A., Komaki, S., Etaee, F., Asadbegi, M., & Komaki‬, A. (2020) · The Journal of Physiological Sciences · doi:10.1186/s12576-020-00747-0 · Cited by 16
Erythropoietin Enhances Post-ischemic Migration and Phagocytosis and Alleviates the Activation of Inflammasomes in Human Microglial Cells
Arik, E., Heinisch, O., Bienert, M., Gubeljak, L., Slowik, A., Reich, A., Schulz, J. B., Wilhelm, T., Huber, M., & Habib, P. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.915348 · Cited by 14
Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors
Kálai, T., Altman, R., Maezawa, I., Balog, M., Morisseau, C. H. P., Petrlová, J., Hammock, B. D., Jin, L., Trudell, J. R., Voss, J. C., et al. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.03.026 · Cited by 14
Impact of Glucocorticoid on a Cellular Model of Parkinson’s Disease: Oxidative Stress and Mitochondrial Function
Claros, S., Gil, A. M., Martinelli, M., Valverde, N., Lara, E., Boraldi, F., Pavı́a, J., Martín‐Montañez, E., & Garcia‐Fernandez, M. I. (2021) · Brain Sciences · doi:10.3390/brainsci11081106 · Cited by 14
Scavenging of photogenerated ROS by Oxicams. Possible biological and environmental implications
Ferrari, G., Natera, J., Montaña, M. P., Muñoz, V., Gutiérrez, E. L., Massad, W. A., Miskoski, S., & Garcı́a, N. A. (2015) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2015.09.024 · Cited by 14
Paradigm shift redefining molecular, metabolic and structural events in Alzheimer’s disease involves a proposed contribution by transition metals. Defined lengthy preclinical stage provides new hope to circumvent advancement of disease- and age-related neurodegeneration
Cavaleri, F. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.01.044 · Cited by 14
Platycodon grandiflorum Root Protects against Aβ-Induced Cognitive Dysfunction and Pathology in Female Models of Alzheimer’s Disease
Nam, Y., Shin, S. J., Park, Y. H., Kim, M., Jeon, S. G., Lee, H., Choi, Y., Kim, T., Shin, S. M., Kim, J.-J., et al. (2021) · Antioxidants · doi:10.3390/antiox10020207 · Cited by 13
High saturated fat and low carbohydrate diet decreases lifespan independent of body weight in mice
Muller, A. P., Dietrich, M. O., de Assis, A. M., Souza, D. O., & Portela, L. V. (2013) · Longevity & Healthspan · doi:10.1186/2046-2395-2-10 · Cited by 14
Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease
Kim, T. K., Hong, J., Kim, K., Han, S. J., Kim, I., Oh, H., & Yim, J. H. (2021) · Molecules · doi:10.3390/molecules26216445 · Cited by 13
A new K+channel-independent mechanism is involved in the antioxidant effect of XE-991 in an in vitro model of glucose metabolism impairment: implications for Alzheimer’s disease
Piccirillo, S., Preziuso, A., Amoroso, S., Serfilippi, T., Miceli, F., Magi, S., & Lariccia, V. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01187-y · Cited by 13
Au-24 as a potential thioredoxin reductase inhibitor in hepatocellular carcinoma cells
Dong, G., Ye, X., Wang, S., Li, W., Cai, R., Du, L., Shi, X., & Li, M. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106113 · Cited by 12
Antidepressant-Like Effect of Ropren® in β-Amyloid-(25–35) Rat Model of Alzheimer’s Disease with Altered Levels of Androgens
Soultanov, V., Fedotova, J., Nikitina, T. V., Roschin, V., Ordyan, N., & Hriţcu, L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9848-8 · Cited by 12
EFFECTS OF LICHENIC EXTRACTS (BRYORIA CAPILLARIS, PELTIGERA RUFESCENS AND XANTHORIA ELEGANS) ON HUMAN BLOOD CELLS: A CYTOGENETIC AND BIOCHEMICAL STUDY
Aydın, E., & Türkez, H. (2011) · Cited by 12
Neuroprotective effects of Fraxinus angustifolia Vahl. bark extract against Alzheimer’s disease
Azib, L., Debbache-Benaida, N., Costa, G. D., Atmani-Kilani, D., Saidène, N., Bouguellid, G., Ourabah, A., Krisa, S., Richard, T., & Atmani, D. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101848 · Cited by 12
A Comprehensive Review of the Benzimidazole Scaffold as a Potential Nucleus for Anti-Ulcer Activity
Singh, K., Bhushan, B., Varma, A. K., Shekhar, R., Sharma, R. K., Ghosh, N. S., Pandey, E., Saha, S., Kumar, S., Mishra, A. K., et al. (2024) · Letters in Organic Chemistry · doi:10.2174/0115701786267759231121070546 · Cited by 11
Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer’s disease by inhibiting neuroinflammation and neuronal necroptosis
Xu, C., Mei, Y., Yang, R., Luo, Q., Zhang, J., Kou, X., Hu, J., Wang, Y., Li, Y., Chen, R., et al. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01230-8 · Cited by 13
Neuromodulatory Potential of Aqueous Extracts of Cumin, Cinnamon: Evidence from Rotenone Model in Drosophila: Implications to Parkinson’s Disease
Rao, S. V., Greeshma, M. V., ., M., & Rajini, P. S. (2016) · International Journal of Neurology Research · doi:10.17554/j.issn.2313-5611.2016.02.60 · Cited by 11
Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic Mice
Zhao, F., Qiao, P., Yan, N., Gao, D., Liu, M., & Yan, Y. P. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1807-7 · Cited by 11
Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia
White, A. L., Talkington, G. M., Ouvrier, B., Ismael, S., Solch-Ottaiano, R. J., & Bix, G. J. (2024) · Biomolecules · doi:10.3390/biom15010006 · Cited by 11
Evaluation of Antioxidant Capacity of Hydrophilic and Hydrophobic Antioxidants Using Peroxyoxalate Chemiluminescence Reaction of the Novel Furandicarboxylate Derivative
Zargoosh, K., Ghayeb, Y., Aeineh, N., & Qandalee, M. (2013) · Food Analytical Methods · doi:10.1007/s12161-013-9625-5 · Cited by 10
FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells
Ye, X., Tai, W., Bao, X., Chen, X., & Zhang, D. (2013) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-013-0918-4 · Cited by 10
Tracking the footprint of pesticides in Alzheimer’s disease
Ghasemi, E., Azad, N. G., Tondar, M., Parirokh, P., & Aval, F. (2015) · Journal of Systems and Integrative Neuroscience · doi:10.15761/jsin.1000104 · Cited by 10
Chemical constituents from a Gynostemma laxum and their antioxidant and neuroprotective activities
Seo, J. Y., Kim, S. K., Nguyễn, P. H., Lee, J. Y., Tung, P. H. T., Sung, S. H., & Oh, W. K. (2017) · Chinese Medicine · doi:10.1186/s13020-017-0136-y · Cited by 10
In vivo Antioxidant Potential of Biogenic Silver Nanoparticles Synthesized from Psidium guajava L.
Yaqub, A., Rashid, M., Ditta, S. A., Malkani, N., Ali, N. M., Yousaf, M. Z., Haider, A., Yousaf, M. J., & Abdullah, S. (2023) · Nano Biomedicine and Engineering · doi:10.26599/nbe.2023.9290026 · Cited by 10
Drug Development for Rare Mitochondrial Disorders
Hurko, O. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0179-4 · Cited by 10
Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer’s diseasePreprint
Ruiz‐Uribe, N. E., Bracko, O., Swallow, M. A., Omurzakov, A., Dash, S., Uchida, H., Xiang, D., Haft‐Javaherian, M., Falkenhain, K., Lamont, M. R. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.15.528710 · Cited by 10
Tannic acid protects neuroblastoma cells against hydrogen peroxide – triggered oxidative stress by suppressing oxidative stress and apoptosis
Yulak, F., & Ergül, M. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149175 · Cited by 9
Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway
Shimada, Y., Kumazoe, M., Otsuka, Y., Tetsuzen, R., Fujimura, Y., & Tachibana, H. (2023) · Journal of Natural Medicines · doi:10.1007/s11418-023-01763-1 · Cited by 9
Acylhydrazones derived from isonicotinic acid: Synthesis, characterization, and evaluation against Alzheimer's disease biomarkers
Frias, C. C., Antoniolli, G., Barros, W. P., & Almeida, W. P. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.138631 · Cited by 9
Effects of Lichenic Extracts (Hypogymnia physodes, Ramalina polymorpha and Usnea florida) on Human Blood Cells: Cytogenetic and Biochemical Study.
Türkez, H., Aydın, E., & Aslan, A. (2012) · Europe PMC (PubMed Central) · Cited by 9
A novel near-infrared probe for the imaging of superoxide anion fluctuations and hydrogen ion enhancement in vivo
Sun, C., Du, W., Zhang, W., Wu, Y., Yao, Z., Wang, B., Wu, T., Yang, H., Wang, Y., & Ren, L. (2018) · Analytical Methods · doi:10.1039/c8ay01190g · Cited by 9
Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer’s Disease by in vitro Electron Paramagnetic Resonance Spectroscopy
Manabe, T., Matsumura, A., Yokokawa, K., Saito, T., Fujikura, M., Iwahara, N., Matsushita, T., Suzuki, S., Hisahara, S., Kawamata, J., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180985 · Cited by 9
Protective effects ofAcanthopanax divaricatusextract in mouse models of Alzheimer's disease
Yan, J.-J., Ahn, W.-G., Jung, J., Kim, H., Hasan, M. A., & Song, D. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.4.386 · Cited by 9
Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells
An, H., Lin, C., Gu, C., Chen, J., Sun, W., Jin, M., Zhang, T.-L., Qiu, M., & Hu, B. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4368 · Cited by 9
Extraction of antioxidants from Peperomia pellucida L. Kunth
Phongtongpasuk, S., & Poadang, S. (2014) · Science & Technology Asia · Cited by 9
Mitochondrial Defects and Oxidative Stress in Alzheimer Disease
Abraki, S. B., & Chavoshinezhad, S. (2014) · The Neuroscience Journal of Shefaye Khatam · doi:10.18869/acadpub.shefa.2.1.85 · Cited by 9
Protective effect of ethyl vanillin against Aβ‑induced neurotoxicity in PC12 cells via the reduction of oxidative stress and apoptosis
Zhong, L., Tong, Y., Chuan, J., Bai, L., Shi, J., & Zhu, Y. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7242 · Cited by 8
Development of a Stand-Alone Independent Graphical User Interface for Neurological Disease Prediction with Automated Extraction and Segmentation of Gray and White Matter in Brain MRI Images
Goyal, A., Tirumalasetty, S., Hossain, G., Challoo, R., Arya, M. K., Agrawal, R. K., & Agrawal, D. K. (2019) · Journal of Healthcare Engineering · doi:10.1155/2019/9610212 · Cited by 8
Sustained adenosine exposure causes endothelial mitochondrial dysfunction via equilibrative nucleoside transporters
Ko, J., Rounds, S., & Lü, Q. (2020) · Pulmonary Circulation · doi:10.1177/2045894020924994 · Cited by 9
Design and evaluation of Nrf2 activators with 1,3,4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells
Lin, H., Qiao, Y., Yang, H., Li, Q., Chen, Y., Qu, W., Liu, W., Feng, F., & Sun, H. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126853 · Cited by 8
Nobiletin Reduces LPS-Induced Neuroinflammation through TLR4/MyD88/NF-κB and Oxidative Stress via Nrf2/HO-1 Signaling in Human Microglial HMC3 Cells
Kritika, Sood, R., Sanjay, S., & Lee, H. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05421-3 · Cited by 7
Pathophysiological Roles of Reactive Oxygen and Nitrogen Species
Kilgour, J. D., & Roberts, R. A. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_10 · Cited by 7
Advances in Research on Down Syndrome
Dey, S. (2018) · InTech eBooks · doi:10.5772/intechopen.68260 · Cited by 7
Radiation-induced cognitive impairment
(2015) · Therapeutic Targets for Neurological Diseases · doi:10.14800/ttnd.837 · Cited by 7
Advancement of disease-modifying therapy of Alzheimer’s disease: from the perspective of new revised criteria for diagnosis and staging of Alzheimer’s disease
Wu, J., Geng, C., Liu, L., & Tang, Y. (2025) · Medicine Plus · doi:10.1016/j.medp.2025.100112 · Cited by 8
A Novel NOX Inhibitor Alleviates Parkinson’s Disease Pathology in PFF-Injected Mice
Ofori, K., Ghosh, A., Verma, D., Wheeler, D., Cabrera, G. N., Seo, J. B., & Kim, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814278 · Cited by 6
UHPLC-Q Exactive-Orbitrap-MS and network pharmacology analyses to investigate the mechanism by which Danggui-Shaoyao-San affects 27-OHC-induced cell damage in SH-SY5Y/C6 coculture
Huang, Y., Zhai, Y., Zhao, D., Wu, M., Shen, Q., Zhao, W., Wang, Q., Yao, L., & Li, W. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-04751-y · Cited by 7
Gallic acid enhances memory, learning and reduces neuroinflammation in a rat model of scopolamine-induced cholinergic dysfunction
Alikhanzade, M., Khosravi, M., Hosseini, M., & Rajabian, A. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01699-w · Cited by 9
From Epimedium to Neuroprotection: Exploring the Potential of Wushanicaritin
Luo, D., Shi, D., & Wen, L. (2024) · Foods · doi:10.3390/foods13101493 · Cited by 6

Authors: Dumont, M., & Beal, M. F.
Affiliations: Weill Cornell Medicine (US)
Corresponding author: Dumont, Magali
ORCID: Dumont, Magali
Beal, M. Flint
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2011-09
Volume: 51
Issue: 5
Pages: 1014-1026
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2010.11.026
PMC: PMC3070183
OpenAlex: W2080084871
Cited by: 402
References: 188
Citations by year: 2026: 12 · 2025: 19 · 2024: 21 · 2023: 20 · 2022: 21 · 2021: 22 · 2020: 26 · 2019: 28 · 2018: 19 · 2017: 36 · 2016: 28 · 2015: 29 · 2014: 36 · 2013: 34 · 2012: 34
FWCI: 2.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (R01AG20729, R01AG020729, P01AG014930, P01-AG14930)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: Alzheimer's disease, reactive oxygen species, oxidative stress, neuroprotection, mitochondria, microglia, neuroinflammation, amyloid-beta clearance, antioxidant defense, transcriptional regulation, neurodegeneration, cognitive decline
MeSH terms: Alzheimer Disease, Animals, Antioxidants, Clinical Trials as Topic, Disease Models, Animal, Humans, Inflammation, Mitochondria, Oxidation-Reduction, Reactive Oxygen Species, Microglia, Oxidative Stress, Disease Progression, Neuroprotective Agents, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroprotective strategies involving ROS in Alzheimer disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks