Beal, M. Flint

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature

Mitochondrial Function and PathologyParkinson's Disease Mechanisms and Treatments

Cited by 6,455

Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer’s disease

Reddy, P. H., & Beal, M. F. (2008) · Trends in Molecular Medicine

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 975

Mitochondria take center stage in aging and neurodegeneration

Beal, M. F. (2005) · Annals of Neurology

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 957

Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia

Browne, S. E., Bowling, A. C., Macgarvey, U., Baik, M. J., Berger, S. C., Muquit, M. M. K., Bird, E. D., & Beal, M. F. (1997) · Annals of Neurology

Genetic Neurodegenerative DiseasesMetabolism and Genetic Disorders

Cited by 885

Oxidatively modified proteins in aging and disease1, 2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease” The full list of papers may be found on the homepage of the journal

Beal, M. F. (2002) · Free Radical Biology and Medicine

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 763

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 757

Parkinson's disease

Thomas, B., & Beal, M. F. (2007) · Human Molecular Genetics

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 748

Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., & Gouras, G. K. (2002) · The American Journal of Pathology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 706

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

Klivenyi, P., Ferrante, R. J., Matthews, R. T., Bogdanov, M. B., Klein, A. M., Andreassen, O. A., Mueller, G., Wermer, M., Kaddurah-Daouk, R., & Beal, M. F. (1999) · Nature Medicine

Amyotrophic Lateral Sclerosis ResearchMitochondrial Function and Pathology

Cited by 682

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

Coskun, P. E., Beal, M. F., & Wallace, D. C. (2004) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 556

Neuroprotective strategies involving ROS in Alzheimer disease

Dumont, M., & Beal, M. F. (2011) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 402

RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

Davis, R. E., Miller, S., Herrnstadt, C., Ghosh, S. S., Fahy, E., Shinobu, L. A., Galasko, D., Thal, L. J., Beal, M. F., Howell, N., et al. (1997) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 341

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 294

Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease

Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., Jenkins, B. G., Ferrante, K. L., Thomas, M., Friedlich, A., Browne, S. E., Schilling, G., Borchelt, D. R., et al. (2001) · Neurobiology of Disease

Genetic Neurodegenerative DiseasesMetabolism and Genetic Disorders

Cited by 293

Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders

Rodriguez, M. C., MacDonald, J. R., Mahoney, D. J., Parise, G., Beal, M. F., & Tarnopolsky, M. A. (2007) · Muscle & Nerve

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 255

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease

Dumont, M., Wille, E., Stack, C., Calingasan, N. Y., Beal, M. F., & Lin, M. T. (2009) · The FASEB Journal

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 221

Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain

Mecocci, P., Beal, M. F., Cecchetti, R., Polidori, M. C., Cherubini, A., Chionne, F., Avellini, L., Romano, G., & Senin, U. (1997) · Molecular and Chemical Neuropathology

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 215

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

Nathan, C., Calingasan, N., Nezezon, J., Ding, A., Lucia, M. S., La Perle, K., Fuortes, M., Lin, M., Ehrt, S., Kwon, N. S., et al. (2005) · The Journal of Experimental Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 214

Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications

Banerjee, R., Beal, M. F., & Thomas, B. (2010) · Trends in Neurosciences

Autophagy in Disease and TherapyAlzheimer's disease research and treatments

Cited by 199

Tolerance of high‐dose (3,000 mg/day) coenzyme Q10 in ALS

Ferrante, K. L., Shefner, J., Zhang, H., Betensky, R., O'Brien, M., Yu, H., Fantasia, M., Taft, J., Beal, M. F., Traynor, B., et al. (2005) · Neurology

Coenzyme Q10 studies and effectsAmyotrophic Lateral Sclerosis Research

Cited by 154

Alzheimer's APP mangles mitochondria

Lin, M. T., & Beal, M. F. (2006) · Nature Medicine

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 143

Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

Simon, D. K., Pulst, S. M., Sutton, J. P., Browne, S. E., Beal, M. F., & Johns, D. R. (1999) · Neurology

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 141

Prophylactic Creatine Administration Mediates Neuroprotection in Cerebral Ischemia in Mice

Zhu, S., Li, M., Figueroa, B. E., Liu, A., Stavrovskaya, I. G., Pasinelli, P., Beal, M. F., Brown, R. H., Kristal, B. S., Ferrante, R. J., et al. (2004) · The Journal of Neuroscience

Neuroprotection in Cerebral IschemiaAcute Ischemic Stroke Management

Cited by 138

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson’s disease

Simon, D. K., Lin, M. T., Zheng, L., Liu, G.-J., Ahn, C. H., Kim, L. M., Mauck, W. M., Twu, F., Beal, M. F., & Johns, D. R. (2004) · Neurobiology of Aging

Mitochondrial Function and PathologyParkinson's Disease Mechanisms and Treatments

Cited by 118