The DOI matches its Crossref record; 423 of the 429 references it cites were found in a registry or an index.
Oxidative stress response and Nrf2 signaling in aging
Open accessAbstract
Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety of age-related pathologies. In aging, oxidant production from several sources is increased, whereas antioxidant enzymes, the primary lines of defense, are decreased. Repair systems, including the proteasomal degradation of damaged proteins, also decline. Importantly, the adaptive response to oxidative stress declines with aging. Nrf2/EpRE signaling regulates the basal and inducible expression of many antioxidant enzymes and the proteasome. Nrf2/EpRE activity is regulated at several levels, including transcription, posttranslation, and interactions with other proteins. This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the changes in Nrf2 regulatory mechanisms with aging.
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“experimental amplification of Nrf2-regulated antioxidant genes has been found to increase resistance to oxidative stress in some aged model systems but not others [207]”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [207]
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“Nrf2 signaling has been found to decrease with age [207] in a variety of model organisms including flies [208], mice [209], non-human primates [210,211], and humans [207,212,213,214].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [207]
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Cited by
Sorted by citations
Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy
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Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
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An aged immune system drives senescence and ageing of solid organs
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Buendía, I., Michalska, P., Navarro, E., Gameiro‐Ros, I., Egea, J., & Leon, R. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.003 · Cited by 698
Metadata
- Authors
- Zhang, H., Davies, K. J. A., & Forman, H. J.
- Affiliations
- University of Southern California (US)
- University of California, Merced (US)
- Corresponding author
- Forman, Henry Jay
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 88
- Issue
- Pt B
- Pages
- 314-336
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC4628850
- OpenAlex
- W2207241376
- Cited by
- 804
- References
- 429
- Citations by year
- 2026: 50 · 2025: 56 · 2024: 75 · 2023: 94 · 2022: 111 · 2021: 92 · 2020: 103 · 2019: 76 · 2018: 56 · 2017: 47 · 2016: 32 · 2015: 12
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. NIH (R01-ES023864, R01-ES003598)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, aging, Nrf2 signaling, antioxidant response element, antioxidant enzymes, proteasome, age-related decline, post-translational regulation, age-related diseases
- MeSH terms
- Aging, Animals, Antioxidants, Gene Expression Regulation, Humans, Signal Transduction, Oxidative Stress, NF-E2-Related Factor 2
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