Oxidative stress response and Nrf2 signaling in aging

Spermatozoa Have Decreased Antioxidant Enzymatic Capacity and Increased Reactive Oxygen Species Production During Aging in the Brown Norway Rat

Weir, C., & Robaire, B. (2007) · Journal of Andrology · doi:10.2164/jandrol.106.001362 · Cited by 131

Phospholipid hydroperoxide glutathione peroxidase: specific activity in tissues of rats of different age and comparison with other glutathione peroxidases

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Glutathione Peroxidase Enzyme Activity in Aging

Espinoza, S. E., Guo, H., Fedarko, N. S., Dezern, A. E., Fried, L. P., Xue, Q., Leng, S. X., Beamer, B., & Walston, J. D. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.5.505 · Cited by 129

Butylated hydroxyanisole regulates ARE‐mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells

Yuan, X., Xu, C., Pan, Z., Keum, Y., Kim, J. H., Shen, G., Yu, S., Oo, K. T., Ma, J., & Kong, A. T. (2006) · Molecular Carcinogenesis · doi:10.1002/mc.20234 · Cited by 128

Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress

Krzywanski, D. M., Dickinson, D. A., Iles, K. E., Wigley, A. F., Franklin, C. C., Liu, R.-M., Kavanagh, T. J., & Forman, H. J. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.11.004 · Cited by 127

Relationship between Human Aging Muscle and Oxidative System Pathway

Doria, E., Buonocore, D., Focarelli, A., & Marzatico, F. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/830257 · Cited by 127

Life Span Extension and H2O2 Resistance Elicited by Caloric Restriction Require the Peroxiredoxin Tsa1 in Saccharomyces cerevisiae

Molin, M., Yang, J., Hanzén, S., Tolédano, M. B., Labarre, J., & Nyström, T. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.027 · Cited by 126

Relationship between Antioxidants, Prooxidants, and the Aging Processa

Sohal, R. S., & Orr, W. C. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38651.x · Cited by 125

Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy

Kocanova, S., Buytaert, E., Matroule, J., Piette, J. G., Gołąb, J., de Witte, P. A. M., & Agostinis, P. (2007) · APOPTOSIS · doi:10.1007/s10495-006-0016-x · Cited by 123

Role of superoxide radical in mitochondrial dehydrogenase reactions

Forman, H. J., & Kennedy, J. A. (1974) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(74)90418-5 · Cited by 122

MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6

Shao, Y., Qu, Y., Dang, S., Yao, B., & Ji, M. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-51 · Cited by 121

Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise

Drummond, M. J., Fry, C. S., Glynn, E. L., Timmerman, K. L., Dickinson, J. M., Walker, D. K., Gundermann, D. M., Volpi, E., & Rasmussen, B. B. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01408.2010 · Cited by 120

Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

Volonte, D., Liu, Z., Musille, P. M., Stoppani, E., Wakabayashi, N., Di, Y.-P., Lisanti, M. P., Kensler, T. W., & Galbiati, F. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-09-0666 · Cited by 119

Aging-Related Oxidative Stress in Healthy Humans

Mendoza-Núñez, V. M., Ruíz-Ramos, M., Sánchez-Rodrı́guez, M. A., Retana-Ugalde, R., & Muñoz-Sánchez, J. L. (2007) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.213.261 · Cited by 116

4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells

Dickinson, D. A., Iles, K. E., Watanabe, N., Iwamoto, T., Zhang, H., Krzywanski, D. M., & Forman, H. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00991-7 · Cited by 116

Nutrigenetics and Modulation of Oxidative Stress

Costa, L. A. D., Badawi, A. F., & El‐Sohemy, A. (2012) · Annals of Nutrition and Metabolism · doi:10.1159/000337311 · Cited by 114

miR-196b targets c-myc and Bcl-2 expression, inhibits proliferation and induces apoptosis in endometriotic stromal cells

Abe, W., Nasu, K., Nakada, C., Kawano, Y., Moriyama, M., & Narahara, H. (2013) · Human Reproduction · doi:10.1093/humrep/des446 · Cited by 114

Redox regulation of the transcriptional repressor Bach1

Ishikawa, M., Numazawa, S., & Yoshida, T. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.021 · Cited by 112

Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain

Emir, U. E., Raatz, S. K., McPherson, S. E., Hodges, J. S., Torkelson, C. J., Tawfik, P. N., White, T. J. H., & Terpstra, M. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1646 · Cited by 111

Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle

Radak, Z. O., Bori, Z., Koltai, E., Fatouros, I. G., Jamurtas, A. Z., DOUROUDOS, I. I., Terzis, G. D., Nikolaidis, M. G., Chatzinikolaou, A., Sovatzidis, A., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.018 · Cited by 109

Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation

Xu, Z., Lam, L. S. M., Lam, L. H., Chau, S. F., Ng, T. B., & Au, S. W. N. (2007) · The FASEB Journal · doi:10.1096/fj.06-7871com · Cited by 108

Expression of SUMO-2/3 Induced Senescence through p53- and pRB-mediated Pathways

Li, T., Santockyte, R., Shen, R., Tekle, E., Wang, G., Yang, D. C. H., & Chock, P. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608236200 · Cited by 107

Oxidative Stress Abolishes Leptomycin B-sensitive Nuclear Export of Transcription Repressor Bach2 That Counteracts Activation of Maf Recognition Element

Hoshino, H., Kobayashi, A., Yoshida, M., Kudo, N. R., Oyake, T., Motohashi, H., Hayashi, N., Yamamoto, M. P., & Igarashi, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15370 · Cited by 106

Bach1 inhibits oxidative stress–induced cellular senescence by impeding p53 function on chromatin

Dohi, Y., Ikura, T., Hoshikawa, Y., Katoh, Y., Ota, K., Nakanome, A., Muto, A., Omura, S., Ohta, T., Ito, A., et al. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1516 · Cited by 104

The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes

Hou, W., Tian, Q., Steuerwald, N., Schrum, L. W., & Bonkovsky, H. L. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.06.001 · Cited by 103

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

Kaspar, J. W., & Jaiswal, A. K. (2010) · The FASEB Journal · doi:10.1096/fj.10-171553 · Cited by 101

Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1–Nrf2, Tgfβ1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice

Wei, J., Zhang, Y., Luo, Y., Wang, Z., Bi, S., Song, D., Dai, Y., Wang, T., Qiu, L., Wen, L., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.10.811 · Cited by 101

A statin‐regulated microRNA represses human c‐Myc expression and function

Takwi, A. A., Li, Y., Buscaglia, L. E. B., Zhang, J., Choudhury, S. N., Park, A. K., Liu, M., Young, K. H., Park, W., Martin, R. C. G., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201101045 · Cited by 101

Upregulation of MiR-155 in Nasopharyngeal Carcinoma is Partly Driven by LMP1 and LMP2A and Downregulates a Negative Prognostic Marker JMJD1A

Du, Z.-M., Hu, L.-F., Wang, H., Yan, L., Zeng, Y., Shao, J., & Ernberg, I. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019137 · Cited by 100

MicroRNAs and the Genetic Network in Aging

Inukai, S., & Slack, F. J. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.01.023 · Cited by 100

Declining signal dependence of Nrf2‐ Maf S ‐regulated gene expression correlates with aging phenotypes

Rahman, M. M., Sykiotis, G. P., Nishimura, M., Bodmer, R., & Bohmann, D. (2013) · Aging Cell · doi:10.1111/acel.12078 · Cited by 100

MYC Is Activated by USP2a-Mediated Modulation of MicroRNAs in Prostate Cancer

Benassi, B., Flavin, R., Marchionni, L., Zanata, S. M., Pan, Y., Chowdhury, D., Marani, M., Strano, S., Muti, P. C., Blandino, G., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0219 · Cited by 100

Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains

de Haan, J. B., Newman, J. D., & Kola, I. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90025-7 · Cited by 98

Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster

Nagy, P., Varga, Á., Pircs, K., Hegedűs, K., & Juhász, G. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003664 · Cited by 98

Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver

Farahmand, S. K., Samini, F., Samini, M., & Samarghandian, S. (2012) · Biogerontology · doi:10.1007/s10522-012-9409-0 · Cited by 96

MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC

Min, D.-J., Ezponda, T., Kim, M. K., Will, C., Martínez-García, E., Popovic, R., Basrur, V., Elenitoba‐Johnson, K. S. J., & Licht, J. D. (2012) · Leukemia · doi:10.1038/leu.2012.269 · Cited by 95

MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis

Yang, J., Tao, H., Hu, W. M., Liu, L., Shi, K., Deng, Z.-Y., & Li, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.07.016 · Cited by 94

Tumor‐suppressive micro RNA ‐135a inhibits cancer cell proliferation by targeting the c‐ MYC oncogene in renal cell carcinoma

Yamada, Y., Hidaka, H., Seki, N., Yoshino, H., Yamasaki, T., Itesako, T., Nakagawa, M., & Enokida, H. (2012) · Cancer Science · doi:10.1111/cas.12072 · Cited by 93

Astroglial Pentose Phosphate Pathway Rates in Response to High-Glucose Environments

Takahashi, S., Izawa, Y., & Suzuki, N. (2012) · ASN NEURO · doi:10.1042/an20120002 · Cited by 93

The Degree of Liver Injury Determines the Role of P21 in Liver Regeneration And Hepatocarcinogenesis in Mice

Buitrago‐Molina, L. E., Marhenke, S., Longerich, T., Sharma, A. D., Boukouris, A. E., Geffers, R., Guigas, B., Manns, M. P., & Vogel, A. (2013) · Hepatology · doi:10.1002/hep.26412 · Cited by 92

Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts

Periyasamy, P., Bidasee, K. R., Ayaki, M., Augusteyn, R. C., Chan, J. Y., & Shinohara, T. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.010 · Cited by 91

Gender difference in glutathione metabolism during aging in mice

Wang, H. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00036-6 · Cited by 89

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes

Bitar, M. S., & Al‐Mulla, F. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00047.2011 · Cited by 89

Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice

Hirota, A., Kawachi, Y., Yamamoto, M. P., Koga, T., Hamada, K., & Otsuka, F. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01292.x · Cited by 88

Hypoxia-Responsive MicroRNA-101 Promotes Angiogenesis via Heme Oxygenase-1/Vascular Endothelial Growth Factor Axis by Targeting Cullin 3

Kim, J.-H., Lee, K.-S., Lee, D.-K., Kim, J., Kwak, S.-N., Ha, K., Choe, J., Won, M., Cho, B. R., Jeoung, D., et al. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5856 · Cited by 88

Hydrogen peroxide responsive miR153 targets Nrf2/ARE cytoprotection in paraquat induced dopaminergic neurotoxicity

Narasimhan, M., Riar, A. K., Rathinam, M. L., Vedpathak, D., Henderson, G. I., & Mahimainathan, L. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.05.020 · Cited by 88

Vitamin E ameliorates enhanced renal lipid peroxidation and accumulation of F2-isoprostanes in aging kidneys

Reckelhoff, J. F., Kanji, V. K., Racusen, L. C., Schmidt, A. M., Yan, S. D., Morrow, J. D., Roberts, L. J., & Salahudeen, A. K. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r767 · Cited by 88

Nrf2 knockout enhances intestinal tumorigenesis in Apcmin/+ mice due to attenuation of anti‐oxidative stress pathway while potentiates inflammation

Cheung, K. L., Lee, J. H., Khor, T. O., Wu, T., Li, G. X., Chan, J. Y., Yang, C. S., & Kong, A. T. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21950 · Cited by 87

The effect of carnosine treatment on prooxidant–antioxidant balance in liver, heart and brain tissues of male aged rats

Aydın, A., Kucukgergin, C., Özdemirler-Erata, G., Koçak-Toker, N., & Uysal, M. (2010) · Biogerontology (Dordrecht) · doi:10.1007/s10522-009-9232-4 · Cited by 87

The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation

Starr, M. E., Ueda, J., Yamamoto, S., Evers, B. M., & Saito, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.013 · Cited by 86

A midlife crisis for the mitochondrial free radical theory of aging

Stuart, J. A., Maddalena, L. A., Merilovich, M., & Robb, E. L. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-4 · Cited by 84

Functional role of p21 during the cellular response to stress.

Gorospe, M., Wang, X., & Holbrook, N. J. (1999) · Europe PMC (PubMed Central) · Cited by 83

Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells

Chen, H., Jin, S., Guo, J., Kombairaju, P., Biswal, S. S., & Zirkin, B. R. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.03.013 · Cited by 82

Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver

Picca, A., Pesce, V., Fracasso, F., Joseph, A.-M., Leeuwenburgh, C., & Lezza, A. M. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074644 · Cited by 82

Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies

Theodore, M., McIntosh, D., Walters, T. S., Flores, A., Goodwin, J. S., & Arinze, I. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.437392 · Cited by 82

Acrolein Induces Heme Oxygenase-1 through PKC-δ and PI3K in Human Bronchial Epithelial Cells

Zhang, H., & Forman, H. J. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0260oc · Cited by 81

Novel insights into the regulation of antioxidant-response-elementmediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2

Jyrkkänen, H.-K., Linna-Kuosmanen, S., Heinäniemi, M., Laitinen, H. M., Kansanen, E., Mella-Aho, E., Leinonen, H. M., Ylä‐Herttuala, S., & Levonen, A. (2011) · Biochemical Journal · doi:10.1042/bj20110526 · Cited by 81

Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism

Meng, D., Wang, X., Chang, Q., Hitron, J. A., Zhang, Z., Xu, M., Chen, G., Luo, J., Jiang, B., Fang, J., et al. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.01.004 · Cited by 80

Effects of MEK5/ERK5 Association on Small Ubiquitin-Related Modification of ERK5: Implications for Diabetic Ventricular Dysfunction After Myocardial Infarction

Shishido, T., Woo, C.-H., Ding, B., McClain, C., Molina, C. A. F., Chen, Y., Yang, J., & Abe, J. (2008) · Circulation Research · doi:10.1161/circresaha.107.168138 · Cited by 80

Effects of Aging on mRNA Profiles for Drug-Metabolizing Enzymes and Transporters in Livers of Male and Female Mice

Fu, Z. D., Csanaky, I. L., & Klaassen, C. D. (2012) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.044461 · Cited by 80

Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population

Chen, K., Yang, Y., Jiang, S., & Jiang, L. (2014) · Histochemistry and Cell Biology · doi:10.1007/s00418-014-1194-1 · Cited by 78

Superoxide Dismutase Activities in Aging Rat Brain

Vanella, A., GEREMIA, E., D’Urso, G., Tiriolo, P., Silvestro, I. D., Grimaldi, R., & Pinturo, R. (2009) · Gerontology · doi:10.1159/000212519 · Cited by 77

Down‐regulation of γ‐glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging

Liu, R.-M. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10217 · Cited by 77

Regulation of oxidative stress by Nrf2 in the pathophysiology of infectious diseases

Deramaudt, T. B., Dill, C., & Bonay, M. (2013) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2013.02.004 · Cited by 76

Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration.

Haeri, M., & Knox, B. E. (2012) · PubMed Central · Cited by 76

Preventive effect of safranal against oxidative damage in aged male rat brain

Samarghandian, S., Azimi–Nezhad, M., & Samini, F. (2014) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.14-0027 · Cited by 76

The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice

Ferenbach, D. A., Nkejabega, N. C. J., McKay, J., Choudhary, A. K., Vernon, M. A., Beesley, M. F., Clay, S., Conway, B. R., Marson, L., Kluth, D., et al. (2011) · Kidney International · doi:10.1038/ki.2010.535 · Cited by 75

Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice

Duan, W., Zhang, R., Guo, Y., Jiang, Y., Huang, Y., Jiang, H., & Li, C. (2009) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-009-9194-5 · Cited by 75

Age-related changes in the function of autophagy in rat kidneys

Cui, J., Bai, X.-Y., Shi, S., Cui, S., Hong, Q., Cai, G., & Chen, X. (2012) · AGE · doi:10.1007/s11357-011-9237-1 · Cited by 75

Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity

Hoshino, T., Tabuchi, K., Nishimura, B., Tanaka, S., Nakayama, M., Ishii, T., Warabi, E., Yanagawa, T., Shimizu, R., Yamamoto, M. P., et al. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.019 · Cited by 75

Age-associated increases in heme oxygenase-1 and ferritin immunoreactivity in the autopsied brain

Hirose, W., Ikematsu, K., & Tsuda, R. (2003) · Legal Medicine · doi:10.1016/s1344-6223(02)00133-5 · Cited by 74

Mitochondrial Autophagy Involving Renal Injury and Aging Is Modulated by Caloric Intake in Aged Rat Kidneys

Cui, J., Shi, S., Sun, X., Cai, G., Cui, S., Hong, Q., Chen, X., & Bai, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069720 · Cited by 73

The Impact of miRNA-Based Molecular Diagnostics and Treatment of NRF2-Stabilized Tumors

Yamamoto, S., Inoue, J., Kawano, T., Kozaki, K., Omura, K., & Inazawa, J. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0246-t · Cited by 72

Aging Adversely Affects the Cigarette Smoke–induced Glutathione Adaptive Response in the Lung

Gould, N. S., Min, E., Gauthier, S., Chu, H. W., Martin, R. J., & Day, B. J. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0442oc · Cited by 72

The antioxidant enzyme peroxiredoxin and its protective role in neurological disorders

Zhu, H., Santo, A., & Li, Y. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011152 · Cited by 72

Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells

He, T., Joyner, M. J., & Katušić, Z. S. (2009) · Microvascular Research · doi:10.1016/j.mvr.2009.08.009 · Cited by 71

Interaction with CREB binding protein modulates the activities of Nrf2 and NF-κB in cystic fibrosis airway epithelial cells

Ziady, A. G., Sokolow, A. G., Shank, S. L., Corey, D. A., Myers, R., Plafker, S. M., & Kelley, T. J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00156.2011 · Cited by 71

Gastrointestinal glutathione peroxidase

Wingler, K., & Brigelius‐Flohé, R. (1999) · BioFactors · doi:10.1002/biof.5520100223 · Cited by 71

Human muscle aging: ROS-mediated alterations in rectus abdominis and vastus lateralis muscles

Marzani, B., Felzani, G., Bellomo, R. G., Vecchiet, J., & Marzatico, F. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.08.010 · Cited by 70

Age-related changes of Nrf2 and phosphorylated GSK-3β in a mouse model of accelerated aging (SAMP8)

Tomobe, K., Shinozuka, T., Kuroiwa, M., & Nomura, Y. (2011) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2011.06.006 · Cited by 70

Lipoic acid restores age‐associated impairment of brain energy metabolism through the modulation of A kt/ JNK signaling and PGC 1α transcriptional pathway

Jiang, T., Yin, F., Yao, J., Brinton, R. D., & Cadenas, E. (2013) · Aging Cell · doi:10.1111/acel.12127 · Cited by 70

Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-κB pathway

Zhao, W., Ma, G., & Chen, X. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.06.008 · Cited by 70

Age and gender dependent levels of glutathione and glutathione S- transferases in human lymphocytes

van Lieshout, E. (1998) · Carcinogenesis · doi:10.1093/carcin/19.10.1873 · Cited by 70

Age Associated Oxidative Damage in Lymphocytes

Gautam, N., Das, S., Mahapatra, S. K., Chakraborty, S. P., Kundu, P. K., & Roy, S. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.4.12860 · Cited by 67

Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells

Zhang, H., Court, N., & Forman, H. J. (2007) · Redox Report · doi:10.1179/135100007x162266 · Cited by 67

Age-related changes of cell death pathways in rat extraocular muscle

McMullen, C. A., Ferry, A. L., Gamboa, J. L., Andrade, F. H., & Dupont‐Versteegden, E. E. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.03.006 · Cited by 66

BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease

Evans, T. A., Raina, A. K., Delacourte, A., Aprelikova, O. N., Lee, H., Zhu, X., Perry, G. L., & Smith, M. A. (2007) · International Journal of Medical Sciences · doi:10.7150/ijms.4.140 · Cited by 66

BRCA1 and Oxidative Stress

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Differential variation of mitochondrial H2O2 release during aging in oxidative and glycolytic muscles in rats

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