Cited by 240DNA Repair MechanismsPARP inhibition in cancer therapyEffects of Radiation Exposure

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Coordination of DNA single strand break repair

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Abbotts, Rachel, Wilson, David M.·2017·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2016.11.039PMC PMC5443707

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Abstract

The genetic material of all organisms is susceptible to modification. In some instances, these changes are programmed, such as the formation of DNA double strand breaks during meiotic recombination to generate gamete variety or class switch recombination to create antibody diversity. However, in most cases, genomic damage is potentially harmful to the health of the organism, contributing to disease and aging by promoting deleterious cellular outcomes. A proportion of DNA modifications are caused by exogenous agents, both physical (namely ultraviolet sunlight and ionizing radiation) and chemical (such as benzopyrene, alkylating agents, platinum compounds and psoralens), which can produce numerous forms of DNA damage, including a range of "simple" and helix-distorting base lesions, abasic sites, crosslinks and various types of phosphodiester strand breaks. More significant in terms of frequency are endogenous mechanisms of modification, which include hydrolytic disintegration of DNA chemical bonds, attack by reactive oxygen species and other byproducts of normal cellular metabolism, or incomplete or necessary enzymatic reactions (such as topoisomerases or repair nucleases). Both exogenous and endogenous mechanisms are associated with a high risk of single strand breakage, either produced directly or generated as intermediates of DNA repair. This review will focus upon the creation, consequences and resolution of single strand breaks, with a particular focus on two major coordinating repair proteins: poly(ADP-ribose) polymerase 1 (PARP1) and X-ray repair cross-complementing protein 1 (XRCC1).

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Authors: Abbotts, R., & Wilson, D. M.
Affiliations: National Institutes of Health (US)
Corresponding author: Wilson, David M.
ORCID: Abbotts, Rachel
Wilson, David M.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2017-06
Volume: 107
Pages: 228-244
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2016.11.039
PMC: PMC5443707
OpenAlex: W2553815939
Cited by: 240
References: 318
Citations by year: 2026: 9 · 2025: 22 · 2024: 25 · 2023: 31 · 2022: 32 · 2021: 41 · 2020: 31 · 2019: 23 · 2018: 18 · 2017: 8
FWCI: 1.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (ZIAAG000751)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords: single-strand breaks, PARP1, XRCC1, DNA damage, reactive oxygen species, abasic sites, DNA cross-links, base lesions, endogenous DNA damage, meiotic recombination, class switch recombination
MeSH terms: Poly (ADP-Ribose) Polymerase-1, X-ray Repair Cross Complementing Protein 1, Animals, Benzopyrenes, DNA Damage, DNA Repair, Humans, Nervous System Diseases, Radiation, Ionizing, Sunlight, Reactive Oxygen Species, DNA Breaks, Single-Stranded

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