Chronic inflammation and the hallmarks of aging

The Hallmarks of Aging

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The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes

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Hallmarks of Cancer: New Dimensions

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mTOR Signaling in Growth Control and Disease

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Shedding light on the cell biology of extracellular vesicles

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Hallmarks of aging: An expanding universe

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The limited in vitro lifetime of human diploid cell strains

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Instability and decay of the primary structure of DNA

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Chronic inflammation in the etiology of disease across the life span

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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Inflammaging: a new immune–metabolic viewpoint for age-related diseases

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Mitochondria: In Sickness and in Health

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Cellular Senescence: Defining a Path Forward

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Biological Functions of Autophagy Genes: A Disease Perspective

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Mitochondrial TCA cycle metabolites control physiology and disease

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mTOR at the nexus of nutrition, growth, ageing and disease

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Association between insulin resistance and the development of cardiovascular disease

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The cGAS–STING pathway as a therapeutic target in inflammatory diseases

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

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mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

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The metabolic signature of macrophage responses

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Putting p53 in context

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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

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Ageing as a Risk Factor for Disease

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Pattern recognition receptors in health and diseases

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PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer

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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

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NAD+ metabolism and its roles in cellular processes during ageing

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Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

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Immunogenic cell stress and death

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A proteomic atlas of senescence-associated secretomes for aging biomarker development

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Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease

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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

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NAD ⁺ in aging, metabolism, and neurodegeneration

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Autophagy in healthy aging and disease

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The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

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Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

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L1 drives IFN in senescent cells and promotes age-associated inflammation

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Writing, erasing and reading histone lysine methylations

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Inflammation and cancer: advances and new agents

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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

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Cellular senescence and senolytics: the path to the clinic

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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

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Trends in oxidative aging theories

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Mitochondrial control of inflammation

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Gut Microbiota and Extreme Longevity

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cGAS is essential for cellular senescence

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Inflammaging and ‘Garb-aging’

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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

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AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network

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Cellular senescence and tumor suppressor gene p16

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Ancient Invasions: From Endosymbionts to Organelles

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The gut microbiome as a modulator of healthy ageing

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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

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Telomere dysfunction in ageing and age-related diseases

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Metabolic Control of Longevity

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Emerging roles of oxidative stress in brain aging and Alzheimer's disease

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Hallmarks of T cell aging

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Telomeres: history, health, and hallmarks of aging

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Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

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Targeting senescent cells enhances adipogenesis and metabolic function in old age

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An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

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Autophagy balances inflammation in innate immunity

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Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

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