Erratum to Gut flora-dependent metabolite trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress [Free Radic. Biol. Med. 116C (2018) 88-100]
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Age-related changes in the microbiota toward gram-negative and endotoxigenic bacteria are known to induce cellular senescence and apoptosis in endothelial cells and damage to intestinal epithelial cells and gut-associated lymphoid tissues, thereby disrupting intestinal epithelial barrier integrity.
“Furthermore, age-related changes in the microbiota toward gram-negative and endotoxigenic bacteria are known to induce cellular senescence and apoptosis in endothelial cells and damage to intestinal epithelial cells and gut-associated lymphoid tissues thereby disrupting the intestinal epithelial barrier integrity (50–54).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [52]
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Saccon, T. D., Nagpal, R., Yadav, H., Cavalcante, M. B., Nunes, A. D. D. C., Schneider, A., Gesing, A., Hughes, B., Yousefzadeh, M., Tchkonia, T., et al. (2021) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glab002 · Cited by 247 · see citing works
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Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk
Heianza, Y., Ma, W., DiDonato, J. A., Sun, Q., Rimm, E. B., Hu, F. B., Rexrode, K. M., Manson, J. E., & Qi, L. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.060 · Cited by 157 · see citing works
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Amelioration of TMAO through probiotics and its potential role in atherosclerosis
Din, A. U., Hassan, A., Zhu, Y. S., Yin, T., Gregersen, H. N., & Wang, G. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10142-4 · Cited by 75 · see citing works
“It was found that higher TMAO levels promote atherosclerosis by platelet hyperactivity and thrombotic events in human (Zhu et al. 2016), as well as through EC senescence, vascular aging, and oxidative stresses (Ke et al. 2018).”
BackgroundSamulak, J. J., Sawicka, A. K., Hartmane, D., Grı̄nberga, S., Pugovičs, O., Łysiak−Szydłowska, W., & Olek, R. A. (2018) · Annals of Nutrition and Metabolism · doi:10.1159/000495037 · Cited by 54 · see citing works
He, Z., Kwek, E., Hao, W., Zhu, H., Liu, J., Ma, K. Y., & Chen, Z. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-020-00535-y · Cited by 51 · see citing works
Self-citationTherapeutic potential of natural products against atherosclerosis: Targeting on gut microbiota
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Review on microbial metabolomics of probiotics and pathogens: Methodologies and applications
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Yu, M., Liu, J., Shi, W., Jiang, M., Hou, H., Xue, Y., Xu, H., Jiang, L., Liu, H., Cheng, D., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202503324r · Cited by 10 · see citing works
“( ii ) S e n e s c e n c e - p r o m o t i n g : H i g h g l u c o s e [ 161 ] , T M A O [ 25 ] , F K 866 [ 162 ] , a n d l o w - d o s e m e t f o r m i n [ 163 ] regulatory roles during senescence and highlight their potential as therapeutic targets for age-related diseases.”
Self-citationEndogenous Metabolites in Metabolic Diseases: Pathophysiologic Roles and Therapeutic Implications
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Hamad, A., Özkan, M. H., & Uma, S. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b20-00767 · Cited by 4 · see citing works
Aging and Cardiovascular Diseases: The Role of Cellular Senescence
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Unraveling the vascular fallout of TMAO in CKD: Time to look beyond GATA4?
Iftikhar, M. K., Hamza, M., Baig, M., & Khan, S. S. (2025) · Journal of Cardiology · doi:10.1016/j.jjcc.2025.07.011
- Authors
- Ke, Y., Li, D., Zhao, M., Liu, C., Liu, J., Zeng, A., Shi, X., Cheng, S., Pan, B., Zheng, L., & Hong, H.
- Affiliations
- Union Hospital (CN)
- Peking University (CN)
- Capital Medical University (CN)
- Fujian Medical University (CN)
- Corresponding author
- Zheng, Lemin
- Hong, Huashan
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 129
- Pages
- 608-610
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2811465419
- Cited by
- 17
- References
- 0
- Citations by year
- 2025: 3 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- trimethylamine N-oxide, gut microbiota, endothelial cell senescence, vascular aging, oxidative stress
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