Ketogenic diets and Alzheimer’s disease
Open accessAbstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid β-peptide plaques and neurofibrillary tangles. Cerebral glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in AD. The early decline in brain glucose metabolism in AD has become a potential target for therapeutic intervention. This has led to investigations assessing the supplementation of the normal glucose supply with ketone bodies which are produced by the body during glucose deprivation and can be metabolized by the brain when glucose utilization is impaired. The present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of AD. Both the direct administration of ketone bodies and the use of high-fat, low-carbohydrate ketogenic diets have been shown to be efficacious in animal models of AD and clinical trials with AD patients. The mechanism underlying the efficacy of ketogenic diets remains unclear, but some evidence points to the normalization of aberrant energy metabolism. At present there is only limited evidence of the usefulness of ketogenic diets in AD. However, this dietary approach seems to be promising and deserves further clinical investigations.
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A ketogenic diet can offer beneficial health effects towards ameliorating symptoms of neurological conditions including autism, depression, epilepsy, cancer, Alzheimer's and Parkinson's diseases.
“Therefore, a ketogenic diet can offer beneficial health effects towards ameliorating symptoms of neurological conditions including autism, depression, epilepsy, cancer, Alzheimer's and Parkinson's diseases (Bostock et al., 2017;Gasior et al., 2006;Lange et al., 2017).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Lange et al., 2017
Section 2, “Development of ketogenic diets” (page not supplied), describes the diet as effective for refractory epilepsy and suggests it may be useful for Alzheimer’s and Parkinson’s diseases. Section 6, “Clinical trials of ketogenic diets in AD” (page not supplied), reports moderate improvement in Alzheimer’s symptoms with ketone-body supplementation. The passages do not support the sentence’s added claims about autism, depression, or cancer. (LLM, conf=0.88)
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Ketogenic Diet in Alzheimer’s Disease
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- Authors
- Lange, K. W., Lange, K. M., Makulska-Gertruda, E., Nakamura, Y., Reissmann, A., Kanaya, S., & Hauser, J.
- Affiliations
- University of Winchester (GB)
- University of Regensburg (DE)
- Nara Institute of Science and Technology (JP)
- Corresponding author
- Lange, Klaus W.
- Venue
- Food Science and Human Wellness
- Publisher
- Tsinghua University Press
- Published
- 2017-03
- Volume
- 6
- Issue
- 1
- Pages
- 1-9
- ISSN
- 2097-0765 (ISSN-L)
- 2213-4530
- OpenAlex
- W2552132939
- Cited by
- 56
- References
- 9
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 3
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Food Science and Human Wellness (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- ketogenic diet, Alzheimer's disease, ketone bodies, brain glucose metabolism, brain hypometabolism, neurofibrillary tangles, energy metabolism, low-carbohydrate high-fat diet, dietary intervention
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