Polycomb response elements and targeting of Polycomb group proteins in Drosophila

A gene complex controlling segmentation in Drosophila

Lewis, E. B. (1978) · Nature · doi:10.1038/276565a0 · Cited by 3,812

Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775

Polycomb complexes repress developmental regulators in murine embryonic stem cells

Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,514

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R. M., Chevalier, B., Johnstone, S. E., Cole, M. F., Isono, K.-I., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,268

Role of histone H2A ubiquitination in Polycomb silencing

Wang, H., Wang, L., Erdjument-Bromage, H., Vidal, M., Tempst, P., Jones, R. S., & Zhang, Y. (2004) · Nature · doi:10.1038/nature02985 · Cited by 1,663

Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex

Müller, J., Hart, C. M., Francis, N. J., Vargas, M. L., Sengupta, A., Wild, B., Miller, E. L., O'Connor, M. B., Kingston, R. E., & Simon, J. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00976-5 · Cited by 1,562

Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites

Czermin, B., Melfi, R., McCabe, D., Seitz, V., Imhof, A., & Pirrotta, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00975-3 · Cited by 1,533

Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins

Ringrose, L., & Paro, R. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091907 · Cited by 1,077

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

Fischle, W., Wang, Y., Jacobs, S. A., Kim, Y., Allis, C. D., & Khorasanizadeh, S. (2003) · Genes & Development · doi:10.1101/gad.1110503 · Cited by 991

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

Pasini, D., Bracken, A. P., Jensen, M. R., Denchi, E. L., & Helin, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600402 · Cited by 916

The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3

Cao, R., & Zhang, Y. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.02.001 · Cited by 914

Role of Bmi-1 and Ring1A in H2A Ubiquitylation and Hox Gene Silencing

Cao, R., Tsukada, Y.-I., & Zhang, Y. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.12.002 · Cited by 857

Chromatin Compaction by a Polycomb Group Protein Complex

Francis, N. J., Kingston, R. E., & Woodcock, C. L. (2004) · Science · doi:10.1126/science.1100576 · Cited by 840

SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex

Cao, R., & Zhang, Y. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.020 · Cited by 812

HMG1 and 2, and related ‘architectural’ DNA-binding proteins

Thomas, J. O., & Travers, A. A. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01801-1 · Cited by 618

Genome-wide analysis of Polycomb targets in Drosophila melanogaster

Schwartz, Y. B., Kahn, T. G., Nix, D. A., Li, X.-Y., Bourgon, R., Biggin, M., & Pirrotta, V. (2006) · Nature Genetics · doi:10.1038/ng1817 · Cited by 610

The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.

Paro, R., & Hogness, D. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.263 · Cited by 569

Hierarchical Recruitment of Polycomb Group Silencing Complexes

Wang, L., Brown, J. L., Cao, R., Zhang, Y., Kassis, J. A., & Jones, R. S. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.009 · Cited by 561

Different Ezh2-Containing Complexes Target Methylation of Histone H1 or Nucleosomal Histone H3

Kuzmichev, A., Jenuwein, T., Tempst, P., & Reinberg, D. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00185-6 · Cited by 449

A group of genes controlling the spatial expression of the bithorax complex in Drosophila

Jürgens, G. (1985) · Nature · doi:10.1038/316153a0 · Cited by 422

The Drosophila Polycomb Group Gene pleiohomeotic Encodes a DNA Binding Protein with Homology to the Transcription Factor YY1

Brown, J. L., Mucci, D., Whiteley, M., Dirksen, M.-L., & Kassis, J. A. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80106-9 · Cited by 409

A Drosophila Polycomb group complex includes Zeste and dTAFII proteins

Saurin, A. J., Shao, Z., Erdjument-Bromage, H., Tempst, P., & Kingston, R. E. (2001) · Nature · doi:10.1038/35088096 · Cited by 403

Histone trimethylation and the maintenance of transcriptional ONand OFF states by trxG and PcG proteins

Papp, B., & Müller, J. (2006) · Genes & Development · doi:10.1101/gad.388706 · Cited by 397

A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities

Klymenko, T., Papp, B., Fischle, W., Köcher, T., Schelder, M., Fritsch, C., Wild, B., Wilm, M., & Müller, J. (2006) · Genes & Development · doi:10.1101/gad.377406 · Cited by 397

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

Tolhuis, B., Muijrers, I., de Wit, E., Teunissen, H., Talhout, W., van Steensel, B., & van Lohuizen, M. (2006) · Nature Genetics · doi:10.1038/ng1792 · Cited by 381

A gene product required for correct initiation of segmental determination in Drosophila

Struhl, G. (1981) · Nature · doi:10.1038/293036a0 · Cited by 366

A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression.

Chan, C. S., Rastelli, L., & Pirrotta, V. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06545.x · Cited by 356

Elements of the Drosophila Bithorax Complex That Mediate Repression by Polycomb Group Products

Simon, J., Chiang, A., Bender, W., Shimell, M. J., & O'Connor, M. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1174 · Cited by 325

Polycomb Silencing Blocks Transcription Initiation

Dellino, G. I., Schwartz, Y. B., Farkas, G., McCabe, D., Elgin, S. C. R., & Pirrotta, V. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00128-5 · Cited by 289

Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila.

Struhl, G., & Akam, M. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04075.x · Cited by 281

POLYCOMBLIKE: A GENE THAT APPEARS TO BE REQUIRED FOR THE NORMAL EXPRESSION OF THE BITHORAX AND ANTENNAPEDIA GENE COMPLEXES OF DROSOPHILA MELANOGASTER

Duncan, I. M. (1982) · Genetics · doi:10.1093/genetics/102.1.49 · Cited by 264

The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins

Klymenko, T., & Müller, J. (2004) · EMBO reports · doi:10.1038/sj.embor.7400111 · Cited by 264

Genome-Wide Prediction of Polycomb/Trithorax Response Elements in Drosophila melanogaster

Ringrose, L., Rehmsmeier, M., Dura, J.-M., & Paro, R. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00337-x · Cited by 261

Polycomb group proteins and heritable silencing of Drosophila Hox genes

Beuchle, D., Struhl, G., & Müller, J. (2001) · Development · doi:10.1242/dev.128.6.993 · Cited by 248

Chromosomal Distribution of PcG Proteins during Drosophila Development

Nègre, N., Hennetin, J., Sun, L. V., Lavrov, S., Bellis, M., White, K. P., & Cavalli, G. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040170 · Cited by 247

Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression

Strutt, H. (1997) · The EMBO Journal · doi:10.1093/emboj/16.12.3621 · Cited by 232

Intergenic transcription through a Polycomb group response element counteracts silencing

Schmitt, S., Prestel, M., & Paro, R. (2005) · Genes & Development · doi:10.1101/gad.326205 · Cited by 230

Division of labor in Polycomb group repression

Levine, S. S., King, I. F. G., & Kingston, R. E. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.07.007 · Cited by 219

Subunit Contributions to Histone Methyltransferase Activities of Fly and Worm Polycomb Group Complexes

Ketel, C. S., Andersen, E. F., Vargas, M. L., Suh, J., Strome, S., & Simon, J. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.6857-6868.2005 · Cited by 216

Structure of a Polycomb Response Element and In Vitro Binding of Polycomb Group Complexes Containing GAGA Factor

Horard, B., Tatout, C., Poux, S., & Pirrotta, V. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.3187-3197.2000 · Cited by 213

Developmental function of Elf-1: an essential transcription factor during embryogenesis in Drosophila.

Bray, S. J., & Kafatos, F. C. (1991) · Genes & Development · doi:10.1101/gad.5.9.1672 · Cited by 198

The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing

Brown, J. L., Fritsch, C., Mueller, J., & Kassis, J. A. (2003) · Development · doi:10.1242/dev.00204 · Cited by 198

The DNA-binding Polycomb group protein Pleiohomeotic mediates silencing of a Drosophila homeotic gene

Fritsch, C., Lesley Brown, J., Kassis, J. A., & Müller, J. (1999) · Development · doi:10.1242/dev.126.17.3905 · Cited by 185

Distinct Contributions of Histone H3 Lysine 9 and 27 Methylation to Locus-Specific Stability of Polycomb Complexes

Ringrose, L., Ehret, H., & Paro, R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.015 · Cited by 181

Binding of Trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis

Orlando, V. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5141 · Cited by 179

Nucleosome binding and histone methyltransferase activity of Drosophila PRC2

Nekrasov, M., Wild, B., & Müller, J. (2005) · EMBO reports · doi:10.1038/sj.embor.7400376 · Cited by 177

Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb region.

Kassis, J. A. (1994) · Genetics · doi:10.1093/genetics/136.3.1025 · Cited by 172

Establishment of Polycomb silencing requires a transient interaction between PC and ESC

Poux, S., Melfi, R., & Pirrotta, V. (2001) · Genes & Development · doi:10.1101/gad.208901 · Cited by 171

Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo.

Müller, J., & Bienz, M. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04876.x · Cited by 165

The GAGA factor is required in the early Drosophila embryo not only for transcriptional regulation but also for nuclear division

Bhat, K. M., Farkas, G., Karch, F., Gyurkovics, H., Gausz, J., & Schedl, P. D. (1996) · Development · doi:10.1242/dev.122.4.1113 · Cited by 161

The MCP silencer of theDrosophila Abd-Bgene requires both Pleiohomeotic and GAGA factor for the maintenance of repression

Busturia, A., Lloyd, A., Bejarano, F., Zavortink, M., Xin, H., & Sakonju, S. (2001) · Development · doi:10.1242/dev.128.11.2163 · Cited by 159

Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1

Déjardin, J., Rappailles, A., Cuvier, O., Grimaud, C., Decoville, M., Locker, D., & Cavalli, G. (2005) · Nature · doi:10.1038/nature03386 · Cited by 157

The Polycomb Group Protein Complex of Drosophila melanogaster Has Different Compositions at Different Target Genes

Strutt, H. L., & Paro, R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.12.6773 · Cited by 149

A 1-Megadalton ESC/E(Z) Complex from Drosophila That Contains Polycomblike and RPD3

Tie, F., Prasad-Sinha, J., Birve, A., Rasmuson-Lestander, Å., & Harte, P. J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3352-3362.2003 · Cited by 140

Polycomb group protein complexes exchange rapidly in living Drosophila

Ficz, G., Heintzmann, R., & Arndt‐Jovin, D. J. (2005) · Development · doi:10.1242/dev.01950 · Cited by 136

Pleiohomeotic Can Link Polycomb to DNA and Mediate Transcriptional Repression

Mohd-Sarip, A., Venturini, F., Chalkley, G. E., & Verrijzer, C. P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7473-7483.2002 · Cited by 135

Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila

Moazed, D., & O’Farrell, P. H. (1992) · Development · doi:10.1242/dev.116.3.805 · Cited by 119

Polycomblike PHD Fingers Mediate Conserved Interaction with Enhancer of Zeste Protein

O’Connell, S., Wang, L., Robert, S. S., Jones, C. A., Saint, R. B., & Jones, R. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104294200 · Cited by 116

The torso response element binds GAGA and NTF-1/Elf-1, and regulates tailless by relief of repression.Preprint

Liaw, G., Rudolph, K. M., Huang, J., Dubnicoff, T., Courey, A. J., & Lengyel, J. A. (1995) · Genes & Development · doi:10.1101/gad.9.24.3163 · Cited by 115

A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc developmentPreprint

Maurange, C., & Paro, R. (2002) · Genes & Development · doi:10.1101/gad.242702 · Cited by 111

A silencer is required for maintenance of transcriptional repression throughout Drosophila development

Busturia, A., Wightman, C. D., & Sakonju, S. (1997) · Development · doi:10.1242/dev.124.21.4343 · Cited by 110

Substrate Preferences of the EZH2 Histone Methyltransferase Complex

Martin, C., Cao, R., & Zhang, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513425200 · Cited by 107

TheDrosophilaTrithorax protein is a coactivator required to prevent re-establishment of Polycomb silencing

Poux, S., Horard, B., Sigrist, C. J. A., & Pirrotta, V. (2002) · Development · doi:10.1242/dev.129.10.2483 · Cited by 103

pipsqueak Encodes a Factor Essential for Sequence-Specific Targeting of a Polycomb Group Protein Complex

Huang, D.-H., Chang, Y.-L., Yang, C., Pan, I.-C., & King, B. O. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6261-6271.2002 · Cited by 100

Site-Specific Recognition of a 70-Base-Pair Element Containing d(GA)n Repeats Mediatesbithoraxoid Polycomb Group Response Element-Dependent Silencing

Hodgson, J. W., Argiropoulos, B., & Brock, H. W. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4528-4543.2001 · Cited by 96

Propagation of Silencing

Lavigne, M., Francis, N. J., King, I. F. G., & Kingston, R. E. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00006-1 · Cited by 95

Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complexPreprint

Mohd-Sarip, A., Cléard, F., Mishra, R. K., Karch, F., & Verrijzer, C. P. (2005) · Genes & Development · doi:10.1101/gad.347005 · Cited by 94

Functional Analysis of Repressor Binding Sites in the iab-2 Regulatory Region of the abdominal-A Homeotic Gene

Shimell, M., Peterson, A. J., Burr, J., Simon, J. A., & O’Connor, M. B. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9576 · Cited by 93

Chromatin inheritance upon Zeste‐mediated Brahma recruitment at a minimal cellular memory module

Déjardin, J., & Cavalli, G. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600108 · Cited by 91

An Sp1/KLF binding site is important for the activity of a Polycomb group response element from the Drosophila engrailed gene

Brown, J. L. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki827 · Cited by 90

Analysis of a Polycomb Group Protein Defines Regions That Link Repressive Activity on Nucleosomal Templates to In Vivo Function

King, I. F. G., Emmons, R. B., Francis, N. J., Wild, B., Müller, J., Kingston, R. E., & Wu, C.-T. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6578-6591.2005 · Cited by 85

Tissue- and stage-specific control of homeotic and segmentation gene expression in Drosophila embryos by the polyhomeotic gene

Dura, J., & Ingham, P. W. (1988) · Development · doi:10.1242/dev.103.4.733 · Cited by 85

Requirement for Sex Comb on Midleg Protein Interactions in Drosophila Polycomb Group Repression

Peterson, A. J., Mallin, D. R., Francis, N. J., Ketel, C. S., Stamm, J., Voeller, R. K., Kingston, R. E., & Simon, J. A. (2004) · Genetics · doi:10.1534/genetics.104.027474 · Cited by 82

Efficient and Specific Targeting of Polycomb Group Proteins Requires Cooperative Interaction between Grainyhead and Pleiohomeotic

Blastyák, A., Mishra, R. K., Karch, F., & Gyurkovics, H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1434-1444.2006 · Cited by 79

Hunchback‐independent silencing of late Ubx enhancers by a Polycomb Group Response Element.

Poux, S., Kostic, C., & Pirrotta, V. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00848.x · Cited by 76

The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing

Lee, H., & Adler, P. N. (2003) · Mechanisms of Development · doi:10.1016/j.mod.2003.11.002 · Cited by 75

GAGA facilitates binding of Pleiohomeotic to a chromatinized Polycomb response element

Mahmoudi, T. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg479 · Cited by 73

Polycomb group-dependent Cyclin A repression in DrosophilaPreprint

Martinez, A., Colomb, S., Déjardin, J., Bantignies, F., & Cavalli, G. (2006) · Genes & Development · doi:10.1101/gad.357106 · Cited by 66

Zeste maintains repression ofUbxtransgenes: support for a new model of Polycomb repression

Hur, M., Laney, J. D., Jeon, S.-H., Ali, J. Y., & Biggin, M. D. (2002) · Development · doi:10.1242/dev.129.6.1339 · Cited by 63

Identification and characterization of polyhomeotic PREs and TREs

Bloyer, S., Cavalli, G., Brock, H. W., & Dura, J. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00314-2 · Cited by 61

zeste, a nonessential gene, potently activates Ultrabithorax transcription in the Drosophila embryo.Preprint

Laney, J. D., & Biggin, M. D. (1992) · Genes & Development · doi:10.1101/gad.6.8.1531 · Cited by 58

General transcriptional silencing by a Polycomb response element in Drosophila

Sengupta, A. K., Kuhrs, A., & Müller, J. (2004) · Development · doi:10.1242/dev.01084 · Cited by 58

DSP1, an HMG-like Protein, Is Involved in the Regulation of Homeotic Genes

Decoville, M., Giacomello, E., Leng, M., & Locker, D. (2001) · Genetics · doi:10.1093/genetics/157.1.237 · Cited by 56

Redundant control of Ultrabithorax by zeste involves functional levels of zeste protein binding at the Ultrabithorax promoter

Laney, J. D., & Biggin, M. D. (1996) · Development · doi:10.1242/dev.122.7.2303 · Cited by 32

Genome Regulation by Polycomb and Trithorax Proteins

Schuettengruber, B., Chourrout, D., Vervoort, M., Leblanc, B., & Cavalli, G. (2007) · Cell · doi:10.1016/j.cell.2007.02.009 · Cited by 1,430

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

Black, J. C., Van Rechem, C., & Whetstine, J. R. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.006 · Cited by 1,308

Polycomb silencing mechanisms and the management of genomic programmes

Schwartz, Y. B., & Pirrotta, V. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1981 · Cited by 868

Roles of the EZH2 histone methyltransferase in cancer epigenetics

Simon, J. A., & Lange, C. A. (2008) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2008.07.010 · Cited by 855

Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis

Zhang, X., Clarenz, O., Cokus, S., Bernatavichute, Y. V., Pellegrini, M., Goodrich, J., & Jacobsen, S. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050129 · Cited by 767