The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
Open accessAbstract
Histone lysine methylation has emerged as a critical player in the regulation of gene expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a tremendous amount of progress has led to the characterization of methyl modifications and the lysine methyltransferases (KMTs) and lysine demethylases (KDMs) that regulate them. Here, we review the discovery and characterization of the KMTs and KDMs and the methyl modifications they regulate. We discuss the localization of the KMTs and KDMs as well as the distribution of lysine methylation throughout the genome. We highlight how these data have shaped our view of lysine methylation as a key determinant of complex chromatin states. Finally, we discuss the regulation of KMTs and KDMs by proteasomal degradation, posttranscriptional mechanisms, and metabolic status. We propose key questions for the field and highlight areas that we predict will yield exciting discoveries in the years to come.
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1 retracted
RETRACTED: Lysyl Oxidase-like 2 Deaminates Lysine 4 in Histone H3
Herranz, N., Dave, N., Millanes‐Romero, A., Morey, L., Diaz, V. M., Lorenz, V., Gallego, R. G., Jerónimo, C., Croce, L. D., de Herreros, A. G., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.03.002 · Cited by 80
RetractedChromatin modifications and their function
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High-Resolution Profiling of Histone Methylations in the Human Genome
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells
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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
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Self-citationLong Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1×
“LncRNAs can also function to repress genes in trans, which is best exemplified by recruitment of PRC2 and KDM1A by HOTAIR (Tsai et al., 2010).”
BackgroundMetabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233
Mapping and analysis of chromatin state dynamics in nine human cell types
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Epigenetic plasticity and the hallmarks of cancer
Flavahan, W. A., Gaskell, E., & Bernstein, B. E. (2017) · Science · doi:10.1126/science.aal2380 · Cited by 1,340
Writing, erasing and reading histone lysine methylations
Hyun, K., Jeon, J., Park, K., & Kim, J. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.11 · Cited by 1,250
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Liu, P.-S., Wang, H., Li, X., Chao, T., Teav, T., Christen, S., Di Conza, G., Cheng, W.-C., Chou, C.-H., Vavakova, M., et al. (2017) · Nature Immunology · doi:10.1038/ni.3796 · Cited by 1,264
H3K4me3 breadth is linked to cell identity and transcriptional consistency
Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., Devarajan, K., Daugherty, A. C., Kundaje, A. B., Mancini, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.027 · Cited by 536
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes
Etchegaray, J.-P., & Mostoslavsky, R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.029 · Cited by 518
Metadata
- Authors
- Black, J. C., Van Rechem, C., & Whetstine, J. R.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 48
- Issue
- 4
- Pages
- 491-507
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2084885369
- Cited by
- 1,308
- References
- 143
- FWCI
- 24.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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