The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Protein kinase signaling networks in cancer
Open accessAbstract
Summary Protein kinases orchestrate the activation of signalling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation, and survival. The complexity of the numerous intracellular signalling pathways is highlighted by the number of kinases encoded by the human genome (539) and the plethora of phosphorylation sites identified in phosphoproteomic studies. Perturbation of these signalling networks by mutations or abnormal protein expression underlies the cause of many diseases including cancer. Recent RNAi screens and cancer genomic sequencing studies have revealed that many more kinases than anticipated contribute to tumorigenesis and are potential targets for inhibitor drug development intervention. This review will highlight recent insights into known pathways essential for tumorigenesis and discuss exciting new pathways for therapeutic intervention.
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Biosensor technology: recent advances in threat agent detection and medicine
Kirsch, J., Siltanen, C., Zhou, Q., Revzin, A., & Simonian, A. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60141b · Cited by 462
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Characterization of covalent binding of tyrosine kinase inhibitors to plasma proteins
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Metadata
- Authors
- Brognard, J., & Hunter, T.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 21
- Issue
- 1
- Pages
- 4-11
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W1993571705
- Cited by
- 240
- References
- 11
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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