The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Combinatorial complexity in chromatin structure and function: revisiting the histone code
Open accessAbstract
Covalent modifications of histone proteins play key roles in transcription, DNA repair, recombination, and other such processes. Over a hundred histone modifications have been described, and a popular idea in the field is that the function of a single histone mark cannot be understood without understanding its combinatorial co-occurrence with other marks, an idea generally called the “histone code hypothesis.” This idea is hotly debated, with increasing biochemical evidence for chromatin regulatory factors that bind to specific histone modification combinations, but functional and localization studies finding minimal combinatorial complexity in histone modification patterns. This review will focus on these contrasting results, and will briefly touch on possible ways to reconcile these conflicting views.
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Cites
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Cited by
Transcriptional Regulation and Its Misregulation in Disease
Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.014 · Cited by 1,620
Absence of a simple code: how transcription factors read the genome
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Epigenetic inheritance uncoupled from sequence-specific recruitment
Ragunathan, K., Jih, G., & Moazed, D. (2015) · Science · doi:10.1126/science.1258699 · Cited by 320
Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis
Bure, I. V., Nemtsova, M. V., & Kuznetsova, E. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105801 · Cited by 253
An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy
Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229
Metadata
- Authors
- Rando, O. J.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 22
- Issue
- 2
- Pages
- 148-155
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W2062247105
- Cited by
- 269
- References
- 51
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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