Cited by 8,679Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromatin Remodeling and Cancer

The language of covalent histone modifications

Strahl, Brian D., Allis, C. David·2000·Nature

Abstract

Histone proteins and the nucleosomes they form with DNA are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often occur on tail domains of these proteins has been well documented. Although the function of these highly conserved modifications has remained elusive, converging biochemical and genetic evidence suggests functions in several chromatin-based processes. We propose that distinct histone modifications, on one or more tails, act sequentially or in combination to form a 'histone code' that is, read by other proteins to bring about distinct downstream events.

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Crossref · 10.1038/47412

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  • The resulting collection of PTMs constitutes a "histone code" that elicits unique gene regulatory responses.

    “The resulting collection of PTMs constitutes a “histone code” that elicits unique gene regulatory responses [44].”

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Authors
Strahl, B. D., & Allis, C. D.
Affiliations
University of Virginia (US)
Corresponding author
Allis, C. David
Venue
Nature
Published
2000-01
Volume
403
Issue
6765
Pages
41-45
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2002698073
Cited by
8,679
References
70
Citations by year
2026: 181 · 2025: 236 · 2024: 276 · 2023: 276 · 2022: 266 · 2021: 335 · 2020: 291 · 2019: 320 · 2018: 302 · 2017: 324 · 2016: 394 · 2015: 395 · 2014: 412 · 2013: 438 · 2012: 416
FWCI
108.42
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
histone modifications, covalent modification, histone code, chromatin, nucleosome, histone tails, post-translational modification, chromatin regulation, epigenetics
MeSH terms
Acetylation, Amino Acid Sequence, Animals, Chromatin, Histones, Humans, Lysine, Microtubules, Models, Biological, Molecular Sequence Data, Phosphorylation, Protein Processing, Post-Translational, Serine

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