The language of covalent histone modifications
Abstract
Histone proteins and the nucleosomes they form with DNA are the fundamental building blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often occur on tail domains of these proteins has been well documented. Although the function of these highly conserved modifications has remained elusive, converging biochemical and genetic evidence suggests functions in several chromatin-based processes. We propose that distinct histone modifications, on one or more tails, act sequentially or in combination to form a 'histone code' that is, read by other proteins to bring about distinct downstream events.
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The resulting collection of PTMs constitutes a "histone code" that elicits unique gene regulatory responses.
“The resulting collection of PTMs constitutes a “histone code” that elicits unique gene regulatory responses [44].”
From Intrinsically disordered proteins play diverse roles in cell signaling (2022) · cites this paper as [44]
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- Authors
- Strahl, B. D., & Allis, C. D.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Allis, C. David
- Venue
- Nature
- Published
- 2000-01
- Volume
- 403
- Issue
- 6765
- Pages
- 41-45
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2002698073
- Cited by
- 8,679
- References
- 70
- Citations by year
- 2026: 181 · 2025: 236 · 2024: 276 · 2023: 276 · 2022: 266 · 2021: 335 · 2020: 291 · 2019: 320 · 2018: 302 · 2017: 324 · 2016: 394 · 2015: 395 · 2014: 412 · 2013: 438 · 2012: 416
- FWCI
- 108.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- histone modifications, covalent modification, histone code, chromatin, nucleosome, histone tails, post-translational modification, chromatin regulation, epigenetics
- MeSH terms
- Acetylation, Amino Acid Sequence, Animals, Chromatin, Histones, Humans, Lysine, Microtubules, Models, Biological, Molecular Sequence Data, Phosphorylation, Protein Processing, Post-Translational, Serine
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