The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Transcription factor–DNA binding: beyond binding site motifs
Open accessAbstract
Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have focused on TFs' intrinsic preferences for primary nucleotide sequence motifs, recent studies have elucidated additional layers of complexity that modulate TF–DNA binding. In this review, we discuss technological developments for identifying TF binding preferences and highlight recent discoveries that elaborate how TF interactions, local DNA structure, and genomic features influence TF–DNA binding. We highlight novel approaches for characterizing functional binding site motifs that promise to inform our understanding of how TF binding controls gene expression and ultimately contributes to phenotype.
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Statistics or biology: the zero-inflation controversy about scRNA-seq data
Jiang, R., Sun, T., Song, D., & Li, J. J. (2022) · Genome Biology · doi:10.1186/s13059-022-02601-5 · Cited by 614
Transcription factors interact with RNA to regulate genes
Oksuz, O., Henninger, J. E., Warneford-Thomson, R., Zheng, M. M., Erb, H., Vancura, A., Overholt, K. J., Hawken, S. W., Banani, S. F., Lauman, R., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.06.012 · Cited by 275
Deep conservation of the enhancer regulatory code in animals
Wong, E. S., Zheng, D., Tan, S. Z., Bower, N. I., Garside, V., Vanwalleghem, G., Gaiti, F., Scott, E., Hogan, B. M., Kikuchi, K., et al. (2020) · Science · doi:10.1126/science.aax8137 · Cited by 176
Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo
Sönmezer, C., Kleinendorst, R., Imanci, D., Barzaghi, G., Villacorta, L., Schübeler, D., Benes, V., Molina, N., & Krebs, A. R. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.11.015 · Cited by 162
Two-Parameter Mobility Assessments Discriminate Diverse Regulatory Factor Behaviors in Chromatin
Lerner, J., Gomez-Garcia, P. A., McCarthy, R. L., Liu, Z., Lakadamyali, M., & Zaret, K. S. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.05.036 · Cited by 110
Metadata
- Authors
- Inukai, S., Kock, K. H., & Bulyk, M. L.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 43
- Pages
- 110-119
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W2602000457
- Cited by
- 392
- References
- 21
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
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