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CRISPR clear? Dimeric Cas9-Fok1 nucleases improve genome-editing specificity
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“The CRISPR/Cas9 genome-editing system provides us an unprecedented opportunity to target and modify genomic sequences with high levels of efficacy and specificity [151,152,153,154,155].”
From Cell Immortality: In Vitro Effective Techniques to Achieve and Investigate Its Applications and Challenges (2024) · cites this paper as [155]
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Research works printed but not linked: 5
- Hsu, 2014, Development and applications of CRISPR-Cas9 for genome engineering, Cell, 157, 1262, 10.1016/j.cell.2014.05.010 · DOI · Paper page
- Kuscu, 2014, Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease, Nat Biotechnol, 32, 677, 10.1038/nbt.2916 · DOI · Paper page
- Cho, 2014, Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases, Genome Res, 24, 132, 10.1101/gr.162339.113 · DOI · Paper page
- Guilinger, 2014, Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification, Nat Biotechnol, 32, 577, 10.1038/nbt.2909 · DOI · Paper page
- Tsai, 2014, Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing, Nat Biotechnol, 32, 569, 10.1038/nbt.2908 · DOI · Paper page
Cited by
Chalak, M., Hesaraki, M., Mirbahari, S. N., Yeganeh, M., Abdi, S., Rajabi, S., & Hemmatzadeh, F. (2024) · Life · doi:10.3390/life14030417 · Cited by 66
Metadata
- Authors
- Zhang, H., Yan, Z., Li, M., Peabody, M., & He, T.-C.
- Venue
- Genes & Diseases
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 1
- Issue
- 1
- Pages
- 6-7
- ISSN
- 2352-3042
- PMC
- PMC4217641
- Cited by
- 4
- References
- 0
- Language
- en
- Funders
- National Institutes of Health (AT004418, CA106569)
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- CoChat. (2026). Citation check: CRISPR clear? Dimeric Cas9-Fok1 nucleases improve genome-editing specificity. https://app.cochat.ai/papers/10.1016/j.gendis.2014.08.004
- The paper
- Zhang, H., Yan, Z., Li, M., Peabody, M., & He, T.-C. (2014). CRISPR clear? Dimeric Cas9-Fok1 nucleases improve genome-editing specificity. Genes & Diseases. https://doi.org/10.1016/j.gendis.2014.08.004
