Cited by 357Antibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyEscherichia coli research studies

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Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43

Chen, Ying-Tsong, Chang, Hwan-You, Lai, Yi-Chyi, Pan, Chao-Chi, Tsai, Shih-Feng, Peng, Hwei-Ling·2004·Gene

DOI 10.1016/j.gene.2004.05.008

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Abstract

We have determined the entire DNA sequence of pLVPK, which is a 219-kb virulence plasmid harbored in a bacteremic isolate of Klebsiella pneumoniae. A total of 251 open reading frames (ORFs) were annotated, of which 37% have homologous genes of known function, 31% match the hypothetical genes in the GenBank database, and the remaining 32% are novel sequences. The obvious virulence-associated genes carried by the plasmid are the capsular polysaccharide synthesis regulator rmpA and its homolog rmpA2, and multiple iron-acquisition systems, including iucABCDiutA and iroBCDN siderophore gene clusters, Mesorhizobium loti fepBC ABC-type transporter, and Escherichia coli fecIRA, which encodes a Fur-dependent regulatory system for iron uptake. In addition, several gene clusters homologous with copper, silver, lead, and tellurite resistance genes of other bacteria were also identified. Identification of a replication origin consisting of a repA gene lying in between two sets of iterons suggests that the replication of pLVPK is iteron-controlled and the iterons are the binding sites for the repA to initiate replication and maintain copy number of the plasmid. Genes homologous with E. coli sopA/sopB and parA/parB with nearby direct DNA repeats were also identified indicating the presence of an F plasmid-like partitioning system. Finally, the presence of 13 insertion sequences located mostly at the boundaries of the aforementioned gene clusters suggests that pLVPK was derived from a sequential assembly of various horizontally acquired DNA fragments.

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Authors: Chen, Y.-T., Chang, H.-Y., Lai, Y.-C., Pan, C.-C., Tsai, S.-F., & Peng, H.-L.
Affiliations: National Yang Ming Chiao Tung University (TW)
National Tsing Hua University (TW)
National Health Research Institutes (TW)
Corresponding author: Peng, Hwei-Ling
ORCID: Chen, Ying-Tsong
Lai, Yi-Chyi
Tsai, Shih-Feng
Peng, Hwei-Ling
Venue: Gene
Publisher: Elsevier BV
Published: 2004-08
Volume: 337
Pages: 189-198
ISSN: 0378-1119 (ISSN-L)
DOI: 10.1016/j.gene.2004.05.008
OpenAlex: W2010955969
Cited by: 351
References: 30
Citations by year: 2026: 16 · 2025: 23 · 2024: 27 · 2023: 26 · 2022: 40 · 2021: 35 · 2020: 30 · 2019: 17 · 2018: 21 · 2017: 14 · 2016: 11 · 2015: 11 · 2014: 14 · 2013: 6 · 2012: 7
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gene (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Council
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Keywords: Klebsiella pneumoniae, virulence plasmid, open reading frames, rmpA, capsular polysaccharide biosynthesis, iron acquisition systems, iutA, RepA, iterons, plasmid replication, plasmid copy number, insertion sequences, horizontal gene transfer, bacteremia
MeSH terms: Amino Acid Sequence, Base Composition, Base Sequence, Chromosome Mapping, DNA Replication, DNA, Bacterial, Genes, Bacterial, Multigene Family, Iron, Klebsiella pneumoniae, Molecular Sequence Data, Plasmids, Virulence, Sequence Homology, Amino Acid, Sequence Analysis, DNA, Metals, Heavy, Drug Resistance, Bacterial

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Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43

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