Identification of ICE2, a gene involved in cold acclimation which determines freezing tolerance in Arabidopsis thaliana

Fursova, Oksana V.; Pogorelko, Gennady V.; Tarasov, Valentin A.

doi:10.1016/j.gene.2008.10.016

Cited by 276Plant Stress Responses and TolerancePlant Molecular Biology ResearchSeed Germination and Physiology

Identification of ICE2, a gene involved in cold acclimation which determines freezing tolerance in Arabidopsis thaliana

Fursova, Oksana V., Pogorelko, Gennady V., Tarasov, Valentin A.·2009·Gene

DOI 10.1016/j.gene.2008.10.016

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Abstract

Several transcription factors are presently known to regulate the response to cold stress. Here we describe a new positive regulator, ICE2, which is a transcription factor of the bHLH family that participates in the response to deep freezing through the cold acclimation-dependent pathway in Arabidopsis thaliana plants. An overexpression of ICE2 (as we named the At1g12860 locus) in transgenic Arabidopsis plants results in increased tolerance to deep freezing stress after cold acclimation. The seeds of transgenic lines that overexpressed ICE2 were characterized by decreased levels of carbohydrate and increased levels of lipids. The analysis of expression of CBF1 gene (also known as DREB1B), which have been shown to be required for the complete development of cold acclimation response in Arabidopsis indicated a difference between expression of the CBF1 gene in transgenic plants and the wild-type control plants, Col-0. These results suggested that the CBF1 transcription factor, known as one of the regulators of the cold stress response, has a dominant role in providing freezing tolerance in transgenic plants characterized by overexpression of ICE2.

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bHLH transcription factors, mainly ICEs, induced by cold are crucial for cold stress tolerance.
“The bHLH transcription factors, mainly ICEs (inducers of CBF expression) induced by the cold are crucial for cold stress tolerance (Fursova et al. 2009), but their role in terpenoid biosynthesis has not been validated.”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Fursova et al. 2009

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Authors: Fursova, O. V., Pogorelko, G. V., & Tarasov, V. A.
Affiliations: Russian Academy of Sciences (RU)
Corresponding author: Pogorelko, Gennady V.
ORCID: Pogorelko, Gennady V.
Venue: Gene
Publisher: Elsevier BV
Published: 2009-01
Volume: 429
Issue: 1-2
Pages: 98-103
ISSN: 0378-1119 (ISSN-L)
DOI: 10.1016/j.gene.2008.10.016
OpenAlex: W2028463864
Cited by: 276
References: 26
Citations by year: 2026: 9 · 2025: 15 · 2024: 14 · 2023: 22 · 2022: 20 · 2021: 27 · 2020: 22 · 2019: 13 · 2018: 20 · 2017: 15 · 2016: 11 · 2015: 18 · 2014: 18 · 2013: 16 · 2012: 11
FWCI: 10.08
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gene (publishedVersion)
PubMed (publishedVersion)
Funders: Institut National de la Recherche Agronomique
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Seed Germination and Physiology
Keywords: bHLH transcription factors, cold acclimation, freezing tolerance, cold stress response, CBF1, transgenic overexpression, seed oil content, seed carbohydrate content, Arabidopsis thaliana
MeSH terms: Acclimatization, Amino Acid Sequence, Carbohydrates, Freezing, Lipids, Molecular Sequence Data, Mutation, RNA, Messenger, Seeds, Trans-Activators, Survival Analysis, Sequence Alignment, Genes, Plant, Arabidopsis, Gene Expression Regulation, Plant, Arabidopsis Proteins, Plants, Genetically Modified, Seedlings, Phase Transition, Basic Helix-Loop-Helix Proteins

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Identification of ICE2, a gene involved in cold acclimation which determines freezing tolerance in Arabidopsis thaliana

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